Results 21 to 30 of about 1,946,344 (262)

TIM-1 Augments Cellular Entry of Ebola Virus Species and Mutants, Which Is Blocked by Recombinant TIM-1 Protein

Microbiology Spectrum, 2022
Ebola virus, a member of the Filoviridae family, utilizes the attachment factors on host cells to support its entry and cause severe tissue damage. TIM-1 has been identified as a predominant attachment factor via interaction with phosphatidylserine (PS ...
Min Zhang, Xinwei Wang, Linhan Hu, Yuting Zhang, Hang Zheng, Haiyan Wu, Jing Wang, Longlong Luo, He Xiao, Chunxia Qiao, Xinying Li, Weijin Huang, Youchun Wang, Jiannan Feng, Guojiang Chen   +14 more
doaj   +1 more source

Ebola Virus Transmission Initiated by Systemic Ebola Virus Disease Relapse

New England Journal of Medicine, 2021
Summary During the 2018-2020 Nord Kivu Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo, an individual who had received the Merck rVSV-ZEBOV vaccine was diagnosed with EVD.
P. Mbala-Kingebeni, C. Pratt, M. Ruffin, M. Pauthner, Faustin N Bile, Antoine Nkuba Ndaye, Allison Black, E. Kinganda Lusamaki, Martin Faye, Amuri Aziza, M. Diagne, Daniel Mukadi, Bailey White, J. Hadfield, K. Gangavarapu, Nella Bisento, Donatien Kazadi, Bibiche Nsunda, Marceline Akonga, Olivier M Tshiani, J. Misasi, Aurélie Ploquin, Victor Epaso, Emilia Sana Paka, Yannick Tutu Tshia N’kasar, Fabrice Mambu, Francois Edidi, Meris Matondo, Junior Bula Bula, B. Diallo, M. Keita, M. Bélizaire, I. Fall, A. Yam, M. Sabue, Anne W. Rimion, Elias L Salfati, A. Torkamani, M. Suchard, Ian Crozier, L. Hensley, A. Rambaut, O. Faye, A. Sall, N. Sullivan, T. Bedford, Kristian G. Andersen, M. Wiley, S. Ahuka-Mundeke, J. Muyembe Tamfum   +49 more
semanticscholar   +1 more source

Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination

Emerging Microbes and Infections, 2023
Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-
Markus H. Kainulainen, Jessica R. Harmon, Amy N. Whitesell, Éric Bergeron, Elif Karaaslan, Caitlin M. Cossaboom, Jason H. Malenfant, Aaron Kofman, Joel M. Montgomery, Mary J. Choi, César G. Albariño, Christina F. Spiropoulou   +11 more
doaj   +1 more source

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.

New England Journal of Medicine, 2019
BACKGROUND Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.
S. Mulangu, L. Dodd, R. Davey, Olivier Tshiani Mbaya, M. Proschan, Daniel Mukadi, Mariano Lusakibanza Manzo, Didier Nzolo, Antoine Tshomba Oloma, Augustin Ibanda, Rosine Ali, Sinaré Coulibaly, A. Levine, R. Grais, Janet Diaz, H. Lane, J. Muyembe‐Tamfum, Billy Sivahera, Modet Camara, R. Kojan, R. Walker, Bonnie Dighero-kemp, H. Cao, Philippe Mukumbayi, P. Mbala-Kingebeni, Steve Ahuka, S. Albert, Tyler Bonnett, Ian Crozier, Michael Duvenhage, C. Proffitt, M. Teitelbaum, T. Moench, J. Aboulhab, K. Barrett, Kelly Cahill, Katherine Cone, R. Eckes, L. Hensley, B. Herpin, E. Higgs, J. Ledgerwood, J. Pierson, M. Smolskis, Ydrissa Sow, J. Tierney, S. Sivapalasingam, Wendy Holman, Nikki Gettinger, D. Vallée, J. Nordwall   +50 more
semanticscholar   +1 more source

The laboratory health system and its response to the Ebola virus disease outbreak in Liberia

African Journal of Laboratory Medicine, 2016
The laboratory system in Liberia has generally been fragmented and uncoordinatedAccordingly, the country’s Ministry of Health established the National Reference Laboratoryto strengthen and sustain laboratory services. However, diagnostic testing services
Stephen B. Kennedy, Christine L. Wasunna, John B. Dogba, Philip Sahr, Candace B. Eastman, Fatorma K. Bolay, Gloria T. Mason, Mark W.S. Kieh   +7 more
doaj   +1 more source

Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]

, 2016
Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline, Dudman, Susanne Gjeruldsen, Fomsgaard, Anders, Karlberg, Helen, Kran, Anne Marte Bakken, Lindegren, Gunnel, Mirazimi, Ali, Rosenstierne, Maiken Wors\uf8e, Salata, Cristiano, Stoltz, Malin Lundahl   +9 more
core   +2 more sources

A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience

Contemporary Clinical Trials Communications, 2018
Introduction: This article describes a retrospective review of participant follow-up and retention strategies in the Partnership for Research on the Ebola Virus in Liberia (PREVAIL) I Vaccine Trial.
Sarah Browne, Tarweh Carter, Risa Eckes, Greg Grandits, Melvin Johnson, Irene Moore, Laura McNay   +6 more
doaj   +1 more source

Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse

Viruses, 2022
During outbreaks of virus diseases, many variants may appear, some of which may be of concern. Stability in an aerosol of several Ebola virus and Marburg virus variants was investigated.
Sophie J. Smither, Lin S. Eastaugh, Mark S. Lever   +2 more
doaj   +1 more source

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Nature, 2016
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents ...
Travis K Warren, R. Jordan, Michael K. Lo, A. Ray, R. Mackman, V. Soloveva, D. Siegel, M. Perron, R. Bannister, H. Hui, Nate Larson, R. Strickley, Jay B. Wells, Kelly S. Stuthman, Sean A. van Tongeren, N. Garza, G. Donnelly, A. Shurtleff, Cary J. Retterer, D. Gharaibeh, Rouzbeh Zamani, Tara A. Kenny, Brett Eaton, Elizabeth C. Grimes, Lisa S. Welch, L. Gomba, C. Wilhelmsen, D. Nichols, J. Nuss, Elyse R. Nagle, Jeffrey R. Kugelman, G. Palacios, Edward M. Doerffler, Sean Neville, Ernest A. Carra, M. Clarke, Lijun Zhang, W. Lew, B. Ross, Q. Wang, K. Chun, Lydia Wolfe, D. Babusis, Yeojin Park, Kirsten M. Stray, Iva Trancheva, Joy Y. Feng, O. Barauskas, Yili Xu, Pamela Wong, Molly R. Braun, M. Flint, L. McMullan, Shan-Shan Chen, R. Fearns, S. Swaminathan, D. Mayers, C. Spiropoulou, William A. Lee, S. Nichol, T. Cihlář, S. Bavari   +61 more
semanticscholar   +1 more source

Pre-Ebola virus disease laboratory system and related challenges in Liberia

African Journal of Laboratory Medicine, 2016
Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of ...
Stephen B. Kennedy, John B. Dogba, Christine L. Wasunna, Philip Sahr, Candace B. Eastman, Fatorma K. Bolay, Gloria T. Mason, Mark W.S. Kieh   +7 more
doaj   +1 more source