Acta Pharmaceutica Sinica B, 2018 Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4 (BSL-4) facilities, which
Qing Chen +4 more
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Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies
Viruses, 2019 Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication.
Md Niaz Rahim +8 more
doaj +2 more sources
Potential mammalian filovirus reservoirs [PDF]
Emerging Infectious Diseases, 2004 Centers for Disease Control and Prevention http://www.cdc.gov/ncidod/EID/vol10no12/04-0346.htmEbola and Marburg viruses are maintained in unknown reservoir species; spillover into human populations results in occasional human cases or epidemics.
Darin S. Carroll +7 more
core +6 more sources
Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names [PDF]
Viruses, 2014 Sequence determination of complete or coding-complete genomes of viruses is becoming common practice for supporting the work of epidemiologists, ecologists, virologists, and taxonomists.
Patterson, Jean L. +164 more
core +13 more sources
An Interagency Collaboration to Facilitate Development of Filovirus Medical Countermeasures
Viruses, 2012 The Filovirus Animal Non-Clinical Group (FANG) is a US interdepartmental and interagency group established to support and facilitate the advanced development of filovirus Medical Countermeasures (MCM), both vaccines and therapeutics.
Edwin O. Nuzum, Nicole Kilgore
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A Call to Action to Enhance Filovirus Disease Outbreak Preparedness and Response
Viruses, 2014 The frequency and magnitude of recognized and declared filovirus-disease outbreaks have increased in recent years, while pathogenic filoviruses are potentially ubiquitous throughout sub-Saharan Africa.
Paul Roddy
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Ecologic and geographic distribution of filovirus disease [PDF]
Emerging Infectious Diseases, 2004 Centers for Disease Control and Prevention http://www.cdc.gov/ncidod/EID/vol10no1/03-0125.htmWe used ecologic niche modeling of outbreaks and sporadic cases of filovirus-associated hemorrhagic fever (HF) to provide a large-scale perspective on the ...
Bauer, John T. +2 more
core +7 more sources
Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions
Viruses, 2012 Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics.
Suchita Bhattacharyya +2 more
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Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine. [PDF]
PLoS Pathogens, 2019 There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen.
Md Niaz Rahim +11 more
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Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir
Viruses, 2019 The 2014 Ebolavirus outbreak in West Africa highlighted the need for vaccines and therapeutics to prevent and treat filovirus infections. A well-characterized small animal model that is susceptible to wild-type filoviruses would facilitate the screening ...
Jason E. Comer +11 more
doaj +2 more sources