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Intravenous (IV) administration of antiviral monoclonal antibodies (mAbs) can be challenging, particularly during an ongoing epidemic, due to the considerable resources required for performing infusions.
Robert W Cross +2 more
exaly +6 more sources
Ebolavirus Replication and Tetherin/BST-2 [PDF]
Ebolavirus (EBOV) is an enveloped, non-segmented, negative-stranded RNA virus, which consists of five species: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SEBOV), Tai Forest ebolavirus (TFEBOV), Bundibugyo ebolavirus (BEBOV), and Reston ebolavirus (REBOV)
Jiro Yasuda
exaly +7 more sources
Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. [PDF]
Ebolavirus (EBOV) is an enveloped, single-stranded, negative-sense RNA virus that causes severe hemorrhagic fever with mortality rates of up to 90% in humans and nonhuman primates.
Asuka Nanbo +7 more
doaj +3 more sources
Testing New Hypotheses Regarding Ebolavirus Reservoirs
Despite a relatively long search for the origin of ebolaviruses, their reservoirs remain elusive. Researchers might have to consider testing alternative hypotheses about how these viruses persist and emerge to advance ebolavirus research.
Siv Aina Jensen Leendertz
exaly +4 more sources
Monoclonal antibodies (mAbs) have proven effective for the treatment of ebolavirus infection in humans, with two mAb-based drugs Inmazeb™ and Ebanga™ receiving FDA approval in 2020.
Andrew B Ward +2 more
exaly +3 more sources
Targeted Medical Interventions for the Prevention and Treatment of Viral Hemorrhagic Fever: A Rapid Systematic Review of Updated Intelligence from the 74th Annual Meeting of the American Society of Tropical Medicine and Hygiene [PDF]
Background: Viral hemorrhagic fevers (VHFs) are severe, often high-consequence, life-threatening illnesses characterized by systemic disease, hemorrhage, and high mortality.
Gregory D. Hawley +11 more
doaj +2 more sources
Ebolaviruses: New roles for old proteins. [PDF]
In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity.
Diego Cantoni, Jeremy S Rossman
doaj +1 more source
La entidad conocida como ébola, recibe esa denominación por el nombre del río más cercano al distrito africano, donde se presentaron los primeros casos del brote en la década de los setenta del siglo XX (1).
Comité Editorial
doaj +1 more source
Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%.
Satoko Yamaoka, Hideki Ebihara
doaj +1 more source
One-Step Reverse-Transcription FRET-PCR for Differential Detection of Five Ebolavirus Species. [PDF]
Ebola is an emerging infectious disease caused by a deadly virus belonging to the family Filoviridae, genus Ebolavirus. Based on their geographical distribution, Ebolavirus has been classified into total five species so far, mainly Zaire, Sudan, Taï ...
Guangwu Lu +6 more
doaj +1 more source

