Experimental Inoculation of Egyptian Rousette Bats (Rousettus aegyptiacus) With Viruses of the Ebolavirus and Marburgvirus Genera [PDF]
Viruses, 2015 The Egyptian rousette bat (Rousettus aegyptiacus) is a natural reservoir for marburgviruses and a consistent source of virus spillover to humans. Cumulative evidence suggests various bat species may also transmit ebolaviruses.
Amy J Schuh +2 more
exaly +7 more sources
Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health [PDF]
Microbial BiotechnologyIn this millennium, Marburgvirus (MARV) outbreaks with very high mortality but still small case numbers (
Harald Brüssow
doaj +3 more sources
Preliminary Investigation of Schmalhausen’s Law in a Directly Transmitted Pathogen Outbreak System [PDF]
Viruses, 2023 The past few decades have been marked by drastic modifications to the landscape by anthropogenic processes, leading to increased variability in the environment. For populations that thrive at their distributional boundaries, these changes can affect them
Antoine Filion +2 more
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Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids [PDF]
Marine DrugsFiloviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang +6 more
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Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats [PDF]
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
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Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1
Cell Reports, 2014 Marburg virus (MARV) has a high fatality rate in humans, causing hemorrhagic fever characterized by massive viral replication and dysregulated inflammation.
Rajesh K Thimmulappa +2 more
exaly +6 more sources
Structures of Marburgvirus Glycoprotein and Its Complex With NPC1 Receptor [PDF]
NatureAbstract Marburgviruses (MBVs) cause severe haemorrhagic fever with higher fatality rates than Ebola virus (EBOV) 1–4 . Here we show that the MBV glycoprotein (GP) mediates viral entry more efficiently than EBOV GP.
Lanying Du, Fang Li, Bin Liu
exaly +4 more sources
Heliyon, 2023 Marburg virus (MARV) has been a major concern since its first outbreak in 1967. Although the deadly BSL-4 pathogen has been reported in few individuals with sporadic outbreaks following 1967, its rarity commensurate the degree of disease severity.
Syed Sikander Azam +2 more
exaly +3 more sources
Prevalence of human filovirus infections in sub-Saharan Africa: A systematic review and meta-analysis protocol [PDF]
Systematic ReviewsBackground Recent outbreaks of Ebola virus disease (EVD) and Marburg virus disease (MVD) in sub-Saharan Africa illustrate the need to better understand animal reservoirs, burden of disease, and human transmission of filoviruses.
Christopher S. Semancik +10 more
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Viruses, 2021 Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi +3 more
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