Results 21 to 30 of about 1,751 (176)

Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1

Cell Reports, 2014
Marburg virus (MARV) has a high fatality rate in humans, causing hemorrhagic fever characterized by massive viral replication and dysregulated inflammation.
Audrey Page, Valentina A. Volchkova, Saint Patrick Reid, Mathieu Mateo, Audrey Bagnaud-Baule, Kirill Nemirov, Amy C. Shurtleff, Philip Lawrence, Oliver Reynard, Michele Ottmann, Vincent Lotteau, Shyam S. Biswal, Rajesh K. Thimmulappa, Sina Bavari, Viktor E. Volchkov   +14 more
doaj   +4 more sources

Untersuchungen zum intrazellulären Transportmechanismus von Marburgvirus Nukleokapsiden

, 2013
Das Marburgvirus bildet zusammen mit dem Ebolavirus die Familie der Filoviridae. Beide Viren lösen beim Menschen und bei nicht-menschlichen Primaten ein starkes hämorrhagisches Fie-ber mit hoher Sterblichkeitsrate aus. Die Viren besitzen ein einzelsträngiges, nicht-segmentiertes RNA-Genom in negativer Orientierung und
Becker, Stephan (Pof. Dr.), Schudt, Gordian   +1 more
openaire   +3 more sources

Untersuchungen zur Rolle des VP24 im Vermehrungszyklus des Marburgvirus

, 2005
The highly pathogenic enveloped Marburgvirus (MARV) is composed of seven structural proteins and the nonsegmented negative-sensed viral RNA genome. Four proteins (NP, VP35, VP30, and L) make up the helical nucleocapsid complex which is surrounded by a matrix that is composed of VP40 and VP24.
Klenk, Hans-Dieter (Prof. Dr.), Bamberg, Sandra   +1 more
core   +4 more sources

Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge [PDF]

Journal of Virology, 2018
ABSTRACT Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV ...
Demetrius, Matassov, Chad E, Mire, Theresa, Latham, Joan B, Geisbert, Rong, Xu, Ayuko, Ota-Setlik, Krystle N, Agans, Dean J, Kobs, Morgan Q S, Wendling, Amanda, Burnaugh, Thomas L, Rudge, Carol L, Sabourin, Michael A, Egan, David K, Clarke, Thomas W, Geisbert, John H, Eldridge   +15 more
openaire   +3 more sources

Prevalence of human filovirus infections in sub-Saharan Africa: A systematic review and meta-analysis protocol [PDF]

Systematic Reviews
Background Recent outbreaks of Ebola virus disease (EVD) and Marburg virus disease (MVD) in sub-Saharan Africa illustrate the need to better understand animal reservoirs, burden of disease, and human transmission of filoviruses.
Christopher S. Semancik, Christopher L. Cooper, Thomas S. Postler, Matt Price, Heejin Yun, Marija Zaric, Monica Kuteesa, Nina Malkevich, Andrew Kilianski, Swati B. Gupta, Suzanna C. Francis   +10 more
doaj   +2 more sources

Conserved Receptor-binding Domains of Lake Victoria Marburgvirus and Zaire Ebolavirus Bind a Common Receptor [PDF]

Journal of Biological Chemistry, 2006
The GP(1,2) envelope glycoproteins (GP) of filoviruses (marburg- and ebolaviruses) mediate cell-surface attachment, membrane fusion, and entry into permissive cells. Here we show that a 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell lines more efficiently than full-length GP1.
Sina Bavari, Sheli Radoshitzky, Michael Farzan   +2 more
exaly   +3 more sources

Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes.

PLoS Pathogens, 2010
Vertebrate genomes contain numerous copies of retroviral sequences, acquired over the course of evolution. Until recently they were thought to be the only type of RNA viruses to be so represented, because integration of a DNA copy of their genome is ...
Vladimir A Belyi, Arnold J Levine, Anna Marie Skalka   +2 more
doaj   +3 more sources

Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system

Virology, 2017
Filoviruses are highly lethal in humans and nonhuman primates, likely due to potent antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is implicated as the major IFN induction antagonist, while Ebola virus (EBOV) VP24 or Marburg virus (MARV) VP40 are known to block downstream IFN signaling.
Jonathan S Towner, Cesar Albarino, Ayan K Chakrabarti   +2 more
exaly   +3 more sources

Funktionelle Charakterisierung der cytoplasmatischen Domäne des Marburgvirus Oberflächenproteins GP

, 2010
The family of Filoviridae comprises Marburg virus (MARV) and Ebola virus, which are the causative agents of fulminant haemorrhagic fevers in humans and non-human primates. Infection of target cells is mediated by binding of viral particles to their cellular receptor, followed by endocytosis, fusion of viral and endosomal membranes, release of the ...
Mittler, Eva-Maria, Lingelbach, Klaus (Prof.Dr.)   +1 more
openaire   +3 more sources

Marburgvirus [PDF]

, 2020
openaire   +2 more sources