Results 21 to 30 of about 2,647 (192)

Marburg Virus Disease: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A, Fakhr SSH, Najafabadi AQ, Karami N, Karami H.   +4 more
europepmc   +2 more sources

Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using <i>Drosophila</i> S2 Cells. [PDF]

Eng Life Sci
ABSTRACT Marburg marburgvirus (MARV) is a highly virulent human pathogen with limited therapeutic options. Recombinant MARV glycoprotein (GP) produced in Drosophila Schneider 2 (S2) cells has been extensively investigated as potential vaccine antigen with promising efficacy demonstrated in nonhuman primate models.
Göbel S, Mayerlen L, Eiser IY, Fichtmueller L, Clements D, Reichl U, Genzel Y, Lehrer A.   +7 more
europepmc   +2 more sources

Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study

Viruses, 2021
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi, Takatsugu Hirokawa, Yoshihiro Takadate, Ayato Takada   +3 more
doaj   +1 more source

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Viruses, 2021
Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as ...
Katendi Changula, Edgar Simulundu, Boniface Pongombo Lombe, Eri Nakayama, Hiroko Miyamoto, Yuji Takahashi, Hirofumi Sawa, Chuma Simukonda, Bernard M. Hang’ombe, Ayato Takada   +9 more
doaj   +1 more source

Communicating the risks of handling bats: analysing approaches used by Australian stakeholders in the context of Australian bat lyssavirus

Australian Veterinary Journal, Volume 101, Issue 11, Page 430-439, November 2023., 2023
Australian bat lyssavirus (ABLV) is a member of the Lyssavirus genus of the Rhabdoviridae family and is found in Australian bat species. It is of public health concern because of the rabies‐like syndrome it causes in humans, resulting in government health and wildlife agencies using varied communication approaches to inform targeted audiences about ...
BP Liang, K Wingett, KL Bosward, MR Taylor   +3 more
wiley   +1 more source

First‐ever Marburg virus disease outbreak in Equatorial Guinea and Tanzania: An imminent crisis in West and East Africa

Immunity, Inflammation and Disease, Volume 11, Issue 8, August 2023., 2023
The Marburg virus causes the severe infectious disease known as Marburg Virus Disease (MVD). Previously, different outbreaks of MVD have appeared in different African countries. For the first time, Equatorial Guinea and Tanzania are experiencing MVD outbreaks.
Olivier Sibomana, Emmanuel Kubwimana
wiley   +1 more source

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens, 2022
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu, Jessica M. Gullett, Thirumala-Devi Kanneganti   +2 more
doaj   +1 more source

The recent outbreaks of Marburg virus disease in African countries are indicating potential threat to the global public health: Future prediction from historical data

Health Science Reports, Volume 6, Issue 7, July 2023., 2023
Abstract Marburg virus disease (MVD) caused by the Marburg virus has a high mortality rate. Rousettus aegyptiacus fruit bats act as the natural reservoir host of the virus. But it can also potentially be transmitted from person to person through direct contact with body secretions.
Iftekhar Ahmed, Lubaba Salsabil, Md. Jamal Hossain, Mohammad Shahriar, Mohiuddin Ahmed Bhuiyan, Md. Rabiul Islam   +5 more
wiley   +1 more source

Development and Structural Analysis of Antibody Therapeutics for Filoviruses

Pathogens, 2022
The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts.
Xiaoying Yu, Erica Ollmann Saphire
doaj   +1 more source

Investigating Infectious Organisms of Public Health Concern Associated with Wild Meat

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
The wild meat trade poses a significant threat to public health as it facilitates the spillover of zoonotic pathogens through high‐risk activities such as the hunting, butchering, trade, and consumption of wild animals. Despite the health risks and association with marking epidemics including SARS, Ebola, and COVID‐19, the global wild meat trade ...
Georgia Kate Moloney, Philippe Gaubert, Sophie Gryseels, Erik Verheyen, Anne-Lise Chaber, Karima Al Salihi   +5 more
wiley   +1 more source