Results 21 to 30 of about 1,760 (181)

Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process [PDF]

Journal of Virology, 2011
ABSTRACT Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection.
Loreen L, Lofts, Jay B, Wells, Sina, Bavari, Kelly L, Warfield   +3 more
openaire   +3 more sources

Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease

BMC Infectious Diseases, 2018
Background Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and international spread.
Peace Babirye, Carol Musubika, Samuel Kirimunda, Robert Downing, Julian J Lutwama, Edward K Mbidde, Jacqueline Weyer, Janusz T Paweska, Moses L Joloba, Misaki Wayengera   +9 more
doaj   +2 more sources

Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge [PDF]

Journal of Virology, 2018
ABSTRACT Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV ...
Demetrius, Matassov, Chad E, Mire, Theresa, Latham, Joan B, Geisbert, Rong, Xu, Ayuko, Ota-Setlik, Krystle N, Agans, Dean J, Kobs, Morgan Q S, Wendling, Amanda, Burnaugh, Thomas L, Rudge, Carol L, Sabourin, Michael A, Egan, David K, Clarke, Thomas W, Geisbert, John H, Eldridge   +15 more
openaire   +3 more sources

Evolutionary maintenance of filovirus-like genes in bat genomes [PDF]

BMC Evolutionary Biology, 2011
Background Little is known of the biological significance and evolutionary maintenance of integrated non-retroviral RNA virus genes in eukaryotic host genomes.
Taylor Derek J, Dittmar Katharina, Ballinger Matthew J, Bruenn Jeremy A   +3 more
doaj   +2 more sources

Unexpected inheritance: multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes.

PLoS Pathogens, 2010
Vertebrate genomes contain numerous copies of retroviral sequences, acquired over the course of evolution. Until recently they were thought to be the only type of RNA viruses to be so represented, because integration of a DNA copy of their genome is ...
Vladimir A Belyi, Arnold J Levine, Anna Marie Skalka   +2 more
doaj   +3 more sources

Untersuchungen zum intrazellulären Transportmechanismus von Marburgvirus Nukleokapsiden

, 2013
Das Marburgvirus bildet zusammen mit dem Ebolavirus die Familie der Filoviridae. Beide Viren lösen beim Menschen und bei nicht-menschlichen Primaten ein starkes hämorrhagisches Fie-ber mit hoher Sterblichkeitsrate aus. Die Viren besitzen ein einzelsträngiges, nicht-segmentiertes RNA-Genom in negativer Orientierung und
Schudt, Gordian (1045774677)
openaire   +3 more sources

Marburg Virus Disease: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A, Fakhr SSH, Najafabadi AQ, Karami N, Karami H.   +4 more
europepmc   +2 more sources

Determination of Seroprevalence of Marburgvirus among Humans in Isiro,Oriental Province,Democratic Republic of Congo [PDF]

, 2015
Marburgvirus and Ebolavirus are among the most virulent pathogens for humans and non-human primates (NHPs) causing outbreaks of fulminant hemorrhagic fever.
Sabiti, Sabin Nundu
core   +4 more sources

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens, 2022
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu, Jessica M. Gullett, Thirumala-Devi Kanneganti   +2 more
doaj   +1 more source

Development and Structural Analysis of Antibody Therapeutics for Filoviruses

Pathogens, 2022
The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts.
Xiaoying Yu, Erica Ollmann Saphire
doaj   +1 more source