Results 11 to 20 of about 1,751 (176)
Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies [PDF]
Frontiers in Immunology, 2017 Marburg virus (MARV) is a highly lethal hemorrhagic fever virus that is increasingly re-emerging in Africa, has been imported to both Europe and the US, and is also a Tier 1 bioterror threat.
Alexander B Taylor, Andrew Hayhurst
exaly +4 more sources
Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry [PDF]
Journal of Virology, 2011 ABSTRACT With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and “cuevaviruses”) cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP 1,2 , to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion.
Sheli R, Radoshitzky +18 more
openaire +3 more sources
Viruses, 2019 We explore evolved soybean ascorbate peroxidase (APEX2) as a reporter when fused to the C-termini of llama nanobodies (single-domain antibodies, sdAb; variable domains of heavy chain-only antibodies, VHH) targeted to the E. coli periplasm.
Laura J. Sherwood, Andrew Hayhurst
doaj +2 more sources
Animal models for Ebola and Marburg virus infections [PDF]
Frontiers in Microbiology, 2013 Ebola and Marburg hemorrhagic fevers (EHF and MHF) are caused by the Filoviridae family, Ebolavirus and Marburgvirus (ebolavirus and marburgvirus), respectively. These severe diseases have high mortality rates in humans.
Eri eNakayama, Masayuki eSaijo
doaj +2 more sources
Discovery of common marburgvirus protective epitopes in a BALB/c mouse model [PDF]
Virology Journal, 2009 Background Marburg virus (MARV) causes acute hemorrhagic fever that is often lethal, and no licensed vaccines are available for preventing this deadly viral infection.
Olinger Gene G +3 more
doaj +3 more sources
Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids [PDF]
Marine DrugsFiloviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang +6 more
doaj +2 more sources
Development of a model for marburgvirus based on severe-combined immunodeficiency mice [PDF]
Virology Journal, 2007 The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model. Previously, a uniformly lethal EBOV-
Kalina Warren V +7 more
doaj +3 more sources
Japanese Journal of Infectious Diseases, 2006 There have recently been large outbreaks of Marburg hemorrhagic fever (MHF) caused by Marburgvirus (MARV) in the Democratic Republic of Congo and Angola. The development of reliable diagnostic systems for MHF is urgently needed. An antigen-capture enzyme-linked immunosorbent assay (Ag-capture ELISA) using either of the two monoclonal antibodies (2A7 ...
Masayuki Saijo, Tetsuya Mizutani
exaly +3 more sources
Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process [PDF]
Journal of Virology, 2011 ABSTRACT Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection.
Loreen L, Lofts +3 more
openaire +3 more sources
Heliyon, 2023 Marburg virus (MARV) has been a major concern since its first outbreak in 1967. Although the deadly BSL-4 pathogen has been reported in few individuals with sporadic outbreaks following 1967, its rarity commensurate the degree of disease severity.
Syed Sikander Azam +2 more
exaly +3 more sources