Results 11 to 20 of about 1,487 (150)
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor [PDF]
NatureAbstract Marburgviruses (MBVs) cause severe haemorrhagic fever with higher fatality rates than Ebola virus (EBOV) 1–4 . Here we show that the MBV glycoprotein (GP) mediates viral entry more efficiently than EBOV GP.
Lanying Du, Fan Bu, Gang Ye
exaly +4 more sources
Recent advances in marburgvirus research [version 1; peer review: 3 approved] [PDF]
F1000Research, 2019 Marburgviruses are closely related to ebolaviruses and cause a devastating disease in humans. In 2012, we published a comprehensive review of the first 45 years of research on marburgviruses and the disease they cause, ranging from molecular biology to ...
Judith Olejnik +2 more
doaj +4 more sources
Marburgvirus Resurgence in Kitaka Mine Bat Population after Extermination Attempts, Uganda
Emerging Infectious Diseases, 2014 To the Editor: Marburg virus (MARV) and Ravn virus (RAVV), collectively called marburgviruses, cause Marburg hemorrhagic fever (MHF) in humans. In July 2007, 4 cases of MHF (1 fatal) occurred in miners at Kitaka Mine in southern Uganda. Later, MHF occurred in 2 tourists who visited Python Cave, ≈50 km from Kitaka Mine.
Anita Mcelroy +2 more
exaly +5 more sources
Discovery of common marburgvirus protective epitopes in a BALB/c mouse model [PDF]
Virology Journal, 2009 Background Marburg virus (MARV) causes acute hemorrhagic fever that is often lethal, and no licensed vaccines are available for preventing this deadly viral infection.
Olinger Gene G +3 more
doaj +3 more sources
Development of a model for marburgvirus based on severe-combined immunodeficiency mice [PDF]
Virology Journal, 2007 The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model. Previously, a uniformly lethal EBOV-
Kalina Warren V +7 more
doaj +3 more sources
PLoS Pathogens, 2010 Vertebrate genomes contain numerous copies of retroviral sequences, acquired over the course of evolution. Until recently they were thought to be the only type of RNA viruses to be so represented, because integration of a DNA copy of their genome is ...
Vladimir A Belyi +2 more
doaj +3 more sources
A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses [PDF]
Nature CommunicationsCross-reactive antibodies targeting multiple epitopes have been identified in Sarbecoviruses, but the precise molecular mechanism(s) behind the crossreactivity remain poorly understood. Here, we isolate 3D1, a broadly neutralizing antibody (bnAb) derived
Lei Yan +17 more
doaj +2 more sources
Marburg Virus Disease: A Narrative Review. [PDF]
Health Sci RepABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A +4 more
europepmc +2 more sources
Viruses, 2021 Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi +3 more
doaj +1 more source
Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using <i>Drosophila</i> S2 Cells. [PDF]
Eng Life SciABSTRACT Marburg marburgvirus (MARV) is a highly virulent human pathogen with limited therapeutic options. Recombinant MARV glycoprotein (GP) produced in Drosophila Schneider 2 (S2) cells has been extensively investigated as potential vaccine antigen with promising efficacy demonstrated in nonhuman primate models.
Göbel S +7 more
europepmc +2 more sources