Journal of Extracellular Vesicles, Volume 11, Issue 3, March 2022., 2022 Abstract A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immune induction remains unclear.
Kai Hu +9 more
wiley +1 more source
Plasmodium berghei‐Mediated NRF2 Activation in Infected Hepatocytes Enhances Parasite Survival
Cellular Microbiology, Volume 2022, Issue 1, 2022., 2022 The protozoan parasite Plasmodium, causative agent of malaria, initially invades and develops in hepatocytes where it resides in a parasitophorous vacuole (PV). A single invaded parasite develops into thousands of daughter parasites. Survival of the host cell is crucial for successful completion of liver stage development.
Annina Bindschedler +7 more
wiley +1 more source
Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry [PDF]
Journal of Virology, 2011 ABSTRACT With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and “cuevaviruses”) cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP 1,2 , to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion.
Sheli R, Radoshitzky +18 more
openaire +2 more sources
Animal models for Ebola and Marburg virus infections
Frontiers in Microbiology, 2013 Ebola and Marburg hemorrhagic fevers (EHF and MHF) are caused by the Filoviridae family, Ebolavirus and Marburgvirus (ebolavirus and marburgvirus), respectively. These severe diseases have high mortality rates in humans.
Eri eNakayama, Masayuki eSaijo
doaj +1 more source
Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]
, 2008 The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher +105 more
core +2 more sources
Filovirus Entry: A Novelty in the Viral Fusion World
Viruses, 2012 Ebolavirus (EBOV) and Marburgvirus (MARV) that compose the filovirus family of negative strand RNA viruses infect a broad range of mammalian cells.
Wendy Maury +2 more
doaj +1 more source
Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
core +2 more sources
Recent outbreak of Marburg virus disease: Could it be a threat for global public health?
, 2023 Health Science Reports, Volume 6, Issue 1, January 2023.
Md. Sohan +3 more
wiley +1 more source
Assessing the feasibility of Phase 3 vaccine trials against Marburg Virus Disease: A modelling study
Vaccine: X, 2023 Background: Outbreaks of Marburg virus disease (MVD) are rare and small in size, with only 18 recorded outbreaks since 1967, only two of which involved more than 100 cases.
George Y. Qian +2 more
doaj +1 more source
Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses. [PDF]
, 2017 Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various filoviruses, but recent outbreaks have greatly expanded our understanding of filovirus immune ...
Agrati +54 more
core +4 more sources