Results 1 to 10 of about 19,816 (168)

Development of an antibody cocktail for treatment of Sudan virus infection [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Ebolaviruses pose a significant threat to the global community, particularly in areas of equatorial and West Africa. While Ebola virus has caused the greatest number of human cases, Sudan virus is responsible for numerous outbreaks with equally lethal consequences.
John Dye, Anna Wec
exaly   +5 more sources

Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development [PDF]

Vaccines, 2022
The primary objective of this study was to characterize the disease course in cynomolgus macaques exposed to Sudan virus (SUDV), to determine if infection in this species is an appropriate model for the evaluation of filovirus countermeasures under the ...
Kendra J. Alfson, Yenny Goez-Gazi, Michal Gazi, Ying-Liang Chou, Nancy A. Niemuth, Marc E. Mattix, Hilary Staples, Benjamin Klaffke, Gloria F. Rodriguez, Priscilla Escareno, Carmen Bartley, Anysha Ticer, Elizabeth A. Clemmons, John W. Dutton III, Anthony Griffiths, Gabe T. Meister, Daniel C. Sanford, Chris M. Cirimotich, Ricardo Carrion   +18 more
doaj   +4 more sources

Serological Evidence of Zika Virus Infections in Sudan

Viruses
Little is known about the frequency of Zika virus (ZIKV) infections in Sudan. The aim of this study was to obtain data on the prevalence of ZIKV infections and the immunity of the population in the country. To this end, 198 sera obtained between December
Awadalkareem Adam, Robert Wenzel, Elisabeth Unger, Sven Reiche, Christian Jassoy   +4 more
doaj   +6 more sources

Molecular characterization of the 2022 Sudan virus disease outbreak in Uganda [PDF]

Journal of Virology, 2023
ABSTRACT Uganda experienced five Ebola disease outbreaks caused by Bundibugyo virus ( n = 1) and Sudan virus (SUDV) ( n = 4) from 2000 to 2021. On 20 September 2022, Uganda declared a fifth Sudan virus disease outbreak in the Mubende district, resulting in 142 confirmed and 22 ...
Isaac Ssewanyana, Julie Harris, Stephen Balinandi   +2 more
exaly   +4 more sources

Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination [PDF]

Emerging Microbes and Infections, 2023
Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-
Markus H. Kainulainen, Jessica R. Harmon, Amy N. Whitesell, Éric Bergeron, Elif Karaaslan, Caitlin M. Cossaboom, Jason H. Malenfant, Aaron Kofman, Joel M. Montgomery, Mary J. Choi, César G. Albariño, Christina F. Spiropoulou   +11 more
doaj   +2 more sources

Sudan virus disease super-spreading, Uganda, 2022. [PDF]

BMC Infect Dis, 2023
Abstract Background On 20 September 2022, Uganda declared its fifth Sudan virus disease (SVD) outbreak, culminating in 142 confirmed and 22 probable cases. The reproductive rate (R) of this outbreak was 1.25. We described persons who were exposed to the virus, became infected, and they led to the infection of an ...
Komakech A, Whitmer S, Izudi J, Kizito C, Ninsiima M, Ahirirwe SR, Kabami Z, Ario AR, Kadobera D, Kwesiga B, Gidudu S, Migisha R, Makumbi I, Eurien D, Kayiwa J, Bulage L, Gonahasa DN, Kyamwine I, Okello PE, Nansikombi HT, Atuhaire I, Asio A, Elayeete S, Nsubuga EJ, Masanja V, Migamba SM, Mwine P, Nakamya P, Nampeera R, Kwiringira A, Akunzirwe R, Naiga HN, Namubiru SK, Agaba B, Zalwango JF, Zalwango MG, King P, Simbwa BN, Zavuga R, Wanyana MW, Kiggundu T, Oonyu L, Ndyabakira A, Komugisha M, Kibwika B, Ssemanda I, Nuwamanya Y, Kamukama A, Aanyu D, Kizza D, Ayen DO, Mulei S, Balinandi S, Nyakarahuka L, Baluku J, Kyondo J, Tumusiime A, Aliddeki D, Masiira B, Muwanguzi E, Kimuli I, Bulwadda D, Isabirye H, Aujo D, Kasambula A, Okware S, Ochien E, Komakech I, Okot C, Choi M, Cossaboom CM, Eggers C, Klena JD, Osinubi MO, Sadigh KS, Worrell MC, Boore AL, Shoemaker T, Montgomery JM, Nabadda SN, Mwanga M, Muruta AN, Harris JR.   +82 more
europepmc   +4 more sources

From reactive trials to regional vaccine sovereignty: a pan-ebolavirus vaccine-readiness framework for East Africa’s Sudan virus and Bundibugyo virus threats [PDF]

Frontiers in Public Health
Vaccines have transformed preparedness for Zaire ebolavirus disease, but East Africa still faces recurrent risk from Sudan virus and Bundibugyo virus, for which licensed and routinely deployable vaccines remain unavailable.
Okechukwu Paul-Chima Ugwu, Chinyere Nneoma Ugwu, Godson Emeka Anyanwu, Mariam Basajja, Maryann Chiamaka Ebuoh   +4 more
doaj   +2 more sources

Multiple Crimean-Congo hemorrhagic fever virus strains are associated with disease outbreaks in Sudan, 2008-2009. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) activity has recently been detected in the Kordufan region of Sudan. Since 2008, several sporadic cases and nosocomial outbreaks associated with high case-fatality have been reported in villages and ...
Imadeldin E Aradaib, Bobbie R Erickson, Mubarak S Karsany, Marina L Khristova, Rehab M Elageb, Mohamed E H Mohamed, Stuart T Nichol   +6 more
doaj   +3 more sources

A Chimeric Sudan Virus-Like Particle Vaccine Candidate Produced by a Recombinant Baculovirus System Induces Specific Immune Responses in Mice and Horses

Viruses, 2020
Ebola virus infections lead to severe hemorrhagic fevers in humans and nonhuman primates; and human fatality rates are as high as 67%−90%. Since the Ebola virus was discovered in 1976, the only available treatments have been medical support or the ...
Fangfang Wu, Shengnan Zhang, Ying Zhang, Ruo Mo, Feihu Yan, Hualei Wang, Gary Wong, Hang Chi, Tiecheng Wang, Na Feng, Yuwei Gao, Xianzhu Xia, Yongkun Zhao, Songtao Yang   +13 more
doaj   +3 more sources

Investigating the Sudan virus outbreak in Uganda through the deployment of a mobile laboratory [PDF]

BMC Infectious Diseases
Background Uganda faced its sixth reported Ebola outbreak between September 2022 and January 2023, the fifth to be recorded as Sudan Virus Disease (SVD) in the country.
Godfrey Pimundu, Tonny Muyigi, Eunice Jennifer Nambozo, Christopher Okiira, Benedict Kanamwanji, Rebecca Nalwanga, Joseph Sekate, Raymond Mugabe, Juliet Naiga, Isaac Sewanyana, Julius Lutwama, Stephen Balinandi, Pontiano Kaleebu, Jane Ruth Aceng, Diana Atwiine, Henry Mwebesa, Henry Kyobe Bosa, Atek Kagirita, Charles Olaro, Andrew Nsawotebba, Emmanuel Achol, Hakim Lagu, Eric Nzeyimana, Juergen May, Florian Gehre, Muna Affara, Susan Nabadda   +26 more
doaj   +2 more sources