Results 1 to 10 of about 1,215,071 (208)

Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination [PDF]

Emerging Microbes and Infections, 2023
Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-
Markus H. Kainulainen, Jessica R. Harmon, Amy N. Whitesell, Éric Bergeron, Elif Karaaslan, Caitlin M. Cossaboom, Jason H. Malenfant, Aaron Kofman, Joel M. Montgomery, Mary J. Choi, César G. Albariño, Christina F. Spiropoulou   +11 more
doaj   +6 more sources

From reactive trials to regional vaccine sovereignty: a pan-ebolavirus vaccine-readiness framework for East Africa’s Sudan virus and Bundibugyo virus threats [PDF]

Frontiers in Public Health
Vaccines have transformed preparedness for Zaire ebolavirus disease, but East Africa still faces recurrent risk from Sudan virus and Bundibugyo virus, for which licensed and routinely deployable vaccines remain unavailable.
Okechukwu Paul-Chima Ugwu, Chinyere Nneoma Ugwu, Godson Emeka Anyanwu, Mariam Basajja, Maryann Chiamaka Ebuoh   +4 more
doaj   +2 more sources

Development of an Antibody Cocktail for Treatment of Sudan Virus Infection [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Ebolaviruses pose a significant threat to the global community, particularly in areas of equatorial and West Africa. While Ebola virus has caused the greatest number of human cases, Sudan virus is responsible for numerous outbreaks with equally lethal consequences.
Danielle Dorosky, John M Dye, Anna Z Wec
exaly   +5 more sources

The Role of Mortality Surveillance in Case Detection and Response During the 2025 Sudan Virus Disease Outbreak in Uganda [PDF]

Journal of Epidemiology and Global Health
Background Developing countries like Uganda, face challenges in containing filovirus outbreaks such as Sudan virus disease (SVD). The 2025 Sudan Virus Disease outbreak in Uganda predominantly affected urban and peri-urban areas.
Rubangakene Moses, Caroline Kyozira, Douglas Bulafu, Mgamb Elizabeth, Rawlance Ndejjo, Okware Solome, Abok Patrick, Agwang Winnie, Steven N. Kabwama, Katushabe Edson, Katusiime Maureen, Mwine Patience, Rhoda K. Wanyenze, Kasonde Mwinga, Muruta Allan   +14 more
doaj   +2 more sources

Investigating the Sudan virus outbreak in Uganda through the deployment of a mobile laboratory [PDF]

BMC Infectious Diseases
Background Uganda faced its sixth reported Ebola outbreak between September 2022 and January 2023, the fifth to be recorded as Sudan Virus Disease (SVD) in the country.
Godfrey Pimundu, Tonny Muyigi, Eunice Jennifer Nambozo, Christopher Okiira, Benedict Kanamwanji, Rebecca Nalwanga, Joseph Sekate, Raymond Mugabe, Juliet Naiga, Isaac Sewanyana, Julius Lutwama, Stephen Balinandi, Pontiano Kaleebu, Jane Ruth Aceng, Diana Atwiine, Henry Mwebesa, Henry Kyobe Bosa, Atek Kagirita, Charles Olaro, Andrew Nsawotebba, Emmanuel Achol, Hakim Lagu, Eric Nzeyimana, Juergen May, Florian Gehre, Muna Affara, Susan Nabadda   +26 more
doaj   +2 more sources

Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development [PDF]

Vaccines, 2022
The primary objective of this study was to characterize the disease course in cynomolgus macaques exposed to Sudan virus (SUDV), to determine if infection in this species is an appropriate model for the evaluation of filovirus countermeasures under the ...
Kendra J. Alfson, Yenny Goez-Gazi, Michal Gazi, Ying-Liang Chou, Nancy A. Niemuth, Marc E. Mattix, Hilary Staples, Benjamin Klaffke, Gloria F. Rodriguez, Priscilla Escareno, Carmen Bartley, Anysha Ticer, Elizabeth A. Clemmons, John W. Dutton III, Anthony Griffiths, Gabe T. Meister, Daniel C. Sanford, Chris M. Cirimotich, Ricardo Carrion   +18 more
doaj   +2 more sources

Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity

Virulence, 2021
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%.
Satoko Yamaoka, Hideki Ebihara
doaj   +1 more source

Serological detection and genetic characterization of foot-and-mouth disease virus from cattle in northern sudan, 2016‑2018

Veterinary and Animal Science, 2021
Northern Sudan is an important corridor cluster between pools of foot-and-mouth disease virus (FMDV) in East and North Africa. It involves almost the whole border area with Egypt and represents a considerable part of a projected disease-free zone in ...
Nussiba H Ahmed, Nussieba A Osman, Wefag Alfouz, Haitham M. Saeed, Yazeed A/Raouf   +4 more
doaj   +1 more source

A Chimeric Sudan Virus-Like Particle Vaccine Candidate Produced by a Recombinant Baculovirus System Induces Specific Immune Responses in Mice and Horses

Viruses, 2020
Ebola virus infections lead to severe hemorrhagic fevers in humans and nonhuman primates; and human fatality rates are as high as 67%−90%. Since the Ebola virus was discovered in 1976, the only available treatments have been medical support or the ...
Fangfang Wu, Shengnan Zhang, Ying Zhang, Ruo Mo, Feihu Yan, Hualei Wang, Gary Wong, Hang Chi, Tiecheng Wang, Na Feng, Yuwei Gao, Xianzhu Xia, Yongkun Zhao, Songtao Yang   +13 more
doaj   +1 more source

Multiple Crimean-Congo hemorrhagic fever virus strains are associated with disease outbreaks in Sudan, 2008-2009. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) activity has recently been detected in the Kordufan region of Sudan. Since 2008, several sporadic cases and nosocomial outbreaks associated with high case-fatality have been reported in villages and ...
Imadeldin E Aradaib, Bobbie R Erickson, Mubarak S Karsany, Marina L Khristova, Rehab M Elageb, Mohamed E H Mohamed, Stuart T Nichol   +6 more
doaj   +1 more source