Results 1 to 10 of about 54,072 (222)

Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination [PDF]

Emerging Microbes and Infections, 2023
Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-
Markus H. Kainulainen, Jessica R. Harmon, Amy N. Whitesell, Éric Bergeron, Elif Karaaslan, Caitlin M. Cossaboom, Jason H. Malenfant, Aaron Kofman, Joel M. Montgomery, Mary J. Choi, César G. Albariño, Christina F. Spiropoulou   +11 more
doaj   +4 more sources

Sudan virus disease super-spreading, Uganda, 2022. [PDF]

BMC Infect Dis, 2023
Abstract Background On 20 September 2022, Uganda declared its fifth Sudan virus disease (SVD) outbreak, culminating in 142 confirmed and 22 probable cases. The reproductive rate (R) of this outbreak was 1.25. We described persons who were exposed to the virus, became infected, and they led to the infection of an ...
Komakech A, Whitmer S, Izudi J, Kizito C, Ninsiima M, Ahirirwe SR, Kabami Z, Ario AR, Kadobera D, Kwesiga B, Gidudu S, Migisha R, Makumbi I, Eurien D, Kayiwa J, Bulage L, Gonahasa DN, Kyamwine I, Okello PE, Nansikombi HT, Atuhaire I, Asio A, Elayeete S, Nsubuga EJ, Masanja V, Migamba SM, Mwine P, Nakamya P, Nampeera R, Kwiringira A, Akunzirwe R, Naiga HN, Namubiru SK, Agaba B, Zalwango JF, Zalwango MG, King P, Simbwa BN, Zavuga R, Wanyana MW, Kiggundu T, Oonyu L, Ndyabakira A, Komugisha M, Kibwika B, Ssemanda I, Nuwamanya Y, Kamukama A, Aanyu D, Kizza D, Ayen DO, Mulei S, Balinandi S, Nyakarahuka L, Baluku J, Kyondo J, Tumusiime A, Aliddeki D, Masiira B, Muwanguzi E, Kimuli I, Bulwadda D, Isabirye H, Aujo D, Kasambula A, Okware S, Ochien E, Komakech I, Okot C, Choi M, Cossaboom CM, Eggers C, Klena JD, Osinubi MO, Sadigh KS, Worrell MC, Boore AL, Shoemaker T, Montgomery JM, Nabadda SN, Mwanga M, Muruta AN, Harris JR.   +82 more
europepmc   +4 more sources

A nosocomial transmission of crimean-congo hemorrhagic fever to an attending physician in north kordufan, Sudan [PDF]

Virology Journal, 2011
Background Crimean-Congo hemorrhagic fever (CCHF), a tick-borne disease caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is a member of the genus Nairovirus in the family Bunyaviridae.
Elbashir Mustafa I, Eltom Kamal H, Hussain Marwa A, Elageb Rehab M, Karsany Mubarak S, Elata Afraa T, Aradaib Imadeldin E   +6 more
doaj   +4 more sources

Sudan virus disease outbreak in Uganda: urgent research gaps. [PDF]

BMJ Glob Health, 2022
The Sudan ebolavirus (SUDV) outbreak highlights our ongoing vulnerability to re-emerging high-consequence infectious diseases. Although the Minister of health in Uganda has initiated public health measures in collaboration with neighbouring countries and with support of the WHO, cases have continued to spread to several regions including the capital ...
Ibrahim SK, Ndwandwe DE, Thomas K, Sigfrid L, Norton A.   +4 more
europepmc   +5 more sources

A Chimeric Sudan Virus-Like Particle Vaccine Candidate Produced by a Recombinant Baculovirus System Induces Specific Immune Responses in Mice and Horses [PDF]

Viruses, 2020
Ebola virus infections lead to severe hemorrhagic fevers in humans and nonhuman primates; and human fatality rates are as high as 67%−90%. Since the Ebola virus was discovered in 1976, the only available treatments have been medical support or the ...
Fangfang Wu, Shengnan Zhang, Ying Zhang, Ruo Mo, Feihu Yan, Hualei Wang, Gary Wong, Hang Chi, Tiecheng Wang, Na Feng, Yuwei Gao, Xianzhu Xia, Yongkun Zhao, Songtao Yang   +13 more
doaj   +2 more sources

Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development [PDF]

Vaccines, 2022
The primary objective of this study was to characterize the disease course in cynomolgus macaques exposed to Sudan virus (SUDV), to determine if infection in this species is an appropriate model for the evaluation of filovirus countermeasures under the ...
Kendra J. Alfson, Yenny Goez-Gazi, Michal Gazi, Ying-Liang Chou, Nancy A. Niemuth, Marc E. Mattix, Hilary Staples, Benjamin Klaffke, Gloria F. Rodriguez, Priscilla Escareno, Carmen Bartley, Anysha Ticer, Elizabeth A. Clemmons, John W. Dutton III, Anthony Griffiths, Gabe T. Meister, Daniel C. Sanford, Chris M. Cirimotich, Ricardo Carrion   +18 more
doaj   +2 more sources

Investigating the Sudan virus outbreak in Uganda through the deployment of a mobile laboratory [PDF]

BMC Infectious Diseases
Background Uganda faced its sixth reported Ebola outbreak between September 2022 and January 2023, the fifth to be recorded as Sudan Virus Disease (SVD) in the country.
Godfrey Pimundu, Tonny Muyigi, Eunice Jennifer Nambozo, Christopher Okiira, Benedict Kanamwanji, Rebecca Nalwanga, Joseph Sekate, Raymond Mugabe, Juliet Naiga, Isaac Sewanyana, Julius Lutwama, Stephen Balinandi, Pontiano Kaleebu, Jane Ruth Aceng, Diana Atwiine, Henry Mwebesa, Henry Kyobe Bosa, Atek Kagirita, Charles Olaro, Andrew Nsawotebba, Emmanuel Achol, Hakim Lagu, Eric Nzeyimana, Juergen May, Florian Gehre, Muna Affara, Susan Nabadda   +26 more
doaj   +2 more sources

Serological Evidence of Zika Virus Infections in Sudan

Viruses
Little is known about the frequency of Zika virus (ZIKV) infections in Sudan. The aim of this study was to obtain data on the prevalence of ZIKV infections and the immunity of the population in the country. To this end, 198 sera obtained between December
Awadalkareem Adam, Robert Wenzel, Elisabeth Unger, Sven Reiche, Christian Jassoy   +4 more
doaj   +3 more sources

Development of a Crystallographic Screening to Identify Sudan Virus VP40 Ligands. [PDF]

ACS Omega
The matrix protein VP40 of the highly pathogenic Sudan virus (genus Orthoebolavirus) is a multifunctional protein responsible for the recruitment of viral nucleocapsids to the plasma membrane and the budding of infectious virions. In addition to its role in assembly, VP40 also downregulates viral genome replication and transcription.
Werner AD, Krapoth N, Norris MJ, Heine A, Klebe G, Saphire EO, Becker S.   +6 more
europepmc   +4 more sources

Sudan Virus Disease among Health Care Workers, Uganda, 2022. [PDF]

N Engl J Med
Wailagala A, Blair PW, Kobba K, Mubaraka K, Aanyu-Tumukahebwa H, Kiiza D, Sekikongo MT, Klena JD, Waitt P, Bahatungire RR, Kyobe HS, Atwine D, Adaku A, Bongomin B, Kirenga B, Boore A, Clark DV, Kaggwa D, Gregory M, Kabweru W, Kayondo W, Mbabazi SK, Kibuuka H, Kimuli I, Mulei S, Mutegeki M, Emmanuel B, Mwebesa H, Naluyima P, Okello S, Tumusiime A, Montgomery J, Vasireddy V, Olaro C, Wayengera M, Lamorde M.   +35 more
europepmc   +3 more sources