Results 41 to 50 of about 7,952 (205)
Development and Structural Analysis of Antibody Therapeutics for Filoviruses
Pathogens, 2022 The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts.
Xiaoying Yu, Erica Ollmann Saphire
doaj +1 more source
Virology Journal, 2018 Background The 2014/2015 Ebolavirus outbreak resulted in more than 28,000 cases and 11,323 reported deaths, as of March 2016. Domestic transmission of the Guinea strain associated with the outbreak occurred mainly in six African countries, and ...
Ameh S. James +4 more
doaj +1 more source
Microarray sequencing results for repository ebolavirus samples.
, 2022 Microarray sequencing results for repository ebolavirus samples.
Moussa Kourout (12072040) +6 more
core +1 more source
The Molecular Genetic Peculiarities of Genomic Structure of Members of the Ebolavirus Genus
Проблемы особо опасных инфекций, 2015 The molecular genetic peculiarities of genomic structure of the Ebolavirus genus members are viewed in the review. The Ebola virus disease outbreaks in West African countries constitute a threat not only for Africa, but for the whole world in view of ...
A. A. Petrov +8 more
doaj +1 more source
Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
PLoS Pathogens, 2008 Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case.
Jonathan S Towner +17 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 Clinical development of Ebola virus vaccines (EVV) was accelerated by the West African Ebola virus epidemic which remains the deadliest in history. To compare and rank the EVV according to their immunogenicity and safety.
Alhassane Diallo +7 more
doaj +1 more source
Frontiers in Immunology, 2021 Three clinically relevant ebolaviruses – Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa.
Pavlo Gilchuk +24 more
doaj +1 more source
Cell Reports, 2018 Summary: Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular understanding of cross-reactive epitopes.
Charles D. Murin +5 more
doaj +1 more source
Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein
Chemistry–Methods, Volume 6, Issue 5, May 2026.The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley +4 more
wiley +1 more source
Virological diagnosis of Ebolavirus infection
Pathology, 2015 Ebolaviruses, and the other viral causes of haemorrhagic fevers (VHF) have always posed special problems for diagnostic laboratories. These arise from the rarity of human infections, minimal documented experience with test delivery and interpretation, the paucity of established commercial or in-house assays, the lack of clinical material for test ...
Smith, D.W. +4 more
openaire +2 more sources