Results 61 to 70 of about 6,334 (171)
A Scoping Review of Machine Learning Applications Across Epidemiological Stages of Zoonotic Disease
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Emerging zoonotic diseases represent a significant threat to global health. While machine learning (ML) holds promise for their management, a comprehensive understanding of how these technologies are applied across the entire animal‐to‐human transmission pathway is lacking.
Yinsheng Zhang +9 more
wiley +1 more source
Discovery of an Ebolavirus-Like Filovirus in Europe
PLoS Pathogens, 2011 (Uploaded by Plazi for the Bat Literature Project) Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease.
Negredo, Ana +16 more
openaire +9 more sources
Health Science Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background and Objective This study employed Mendelian randomization (MR) to investigate the causal relationships between 4907 circulating proteins and hyperlipidemia, with the aim of identifying potential drug targets. Methods Instrumental variables were derived from genome‐wide association study (GWAS) data on 4907 circulating proteins ...
Hui Cheng, Dayuan Zhong
wiley +1 more source
Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor
MedComm, Volume 6, Issue 9, September 2025.Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang +9 more
wiley +1 more source
[Ebola virus (Filoviridae: Ebolavirus: Zaire ebolavirus): fatal adaptation mutations].
Voprosy virusologii, 2021 Ebola virus disease (EVD) (former Ebola hemorrhagic fever) is one of the most dangerous infectious diseases affecting humans and primates. Since the identification of the first outbreak in 1976, there have been more than 25 outbreaks worldwide, the largest of which escalated into an epidemic in 2014-2016 and caused the death of more than 11,000 people.
I. V. Dolzhikova +3 more
openaire +2 more sources
Viruses, 2014 In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa.
Jens H. Kuhn +43 more
doaj +1 more source
Characterization of Ebolavirus regulatory genomic regions [PDF]
Virus Research, 2009 For filoviruses, such as Ebolavirus and the closely related Marburgvirus, transcriptional regulation is poorly understood. The open reading frames (ORFs) that encode the viral proteins are separated by regulatory regions composed of the 3' nontranslated region (NTR) of the upstream gene, highly conserved transcription stop and start signals, and the 5 ...
Gabriele, Neumann +2 more
openaire +2 more sources
An Interagency Collaboration to Facilitate Development of Filovirus Medical Countermeasures
Viruses, 2012 The Filovirus Animal Non-Clinical Group (FANG) is a US interdepartmental and interagency group established to support and facilitate the advanced development of filovirus Medical Countermeasures (MCM), both vaccines and therapeutics.
Edwin O. Nuzum, Nicole Kilgore
doaj +1 more source
Mapping the Potential Risk of Coronavirus Spillovers in a Global Hotspot
Global Change Biology, Volume 31, Issue 9, September 2025.Bats host a vast array of viruses, including those behind SARS and COVID‐19. This study maps coronavirus spillover risk hotspots across South and Southeast Asia by combining horseshoe bat species distributions, forest fragmentation, and human population density.
R. Sedricke Lapuz +2 more
wiley +1 more source
Replication-Deficient Ebolavirus as a Vaccine Candidate [PDF]
Journal of Virology, 2009 ABSTRACT Ebolavirus causes severe hemorrhagic fever, with case fatality rates as high as 90%. Currently, no licensed vaccine is available against Ebolavirus. We previously generated a replication-deficient, biologically contained Ebolavirus, EbolaΔVP30, which lacks the essential VP30 gene, grows only in cells stably expressing ...
Peter, Halfmann +8 more
openaire +2 more sources