Results 51 to 60 of about 6,334 (171)

Ebolavirus Evolution: Past and Present

PLOS Pathogens, 2015
(Uploaded by Plazi for the Bat Literature Project) The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time ...
De La Vega, Marc-Antoine, Stein, Derek, Kobinger, Gary P, Hobman, Tom C.   +3 more
openaire   +5 more sources

Ebolavirus and Marburgvirus: Insight the Filoviridae family [PDF]

Molecular Aspects of Medicine, 2008
Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule.
Ascenzi P, Bocedi A, Heptonstall J, Capobianchi MR, Di Caro A, Mastrangelo E, Bolognesi M, Ippolito G   +7 more
openaire   +7 more sources

Comparative Analysis of the Sequenced Zaire ebolavirus Samples from the Republic of Guinea

Проблемы особо опасных инфекций, 2015
An unprecedented on its scale Ebola fever epidemic, caused by Zaire ebolavirus, has been registered in the territory of West Africa in 2014-2015. The virus quickly spread from the Republic of Guinea into the neighboring countries.
Ya. M. Krasnov, V. A. Safronov, N. Yu. Nosov, V. V. Kutyrev, A. Yu. Popova   +4 more
doaj   +1 more source

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Ebola virus disease: past, present and future

Asian Pacific Journal of Tropical Biomedicine, 2015
Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate (up to 90%) accompanying with the disease. Ebola haemorrhagic fever (EHF) is an infectious disease of animal that can be transmitted to both human and ...
Harish Rajak, Deepak Kumar Jain, Avineesh Singh, Ajay Kumar Sharma, Anshuman Dixit   +4 more
doaj   +1 more source

Nicotiana benthamiana as a Source of Cowpea Mosaic Virus‐Derived Particles That Specifically Package Designer RNAs

Plant Biotechnology Journal, Volume 24, Issue 1, Page 159-170, January 2026.
ABSTRACT The coupling of replication and encapsidation in the bipartite plant virus, cowpea mosaic virus (CPMV), has been used to specifically incorporate designer RNA molecules into viral particles via transient expression in Nicotiana benthamiana. This is achieved by placing the desired RNA sequence between the 5′ and 3′ UTRs of CPMV RNA‐2 so that ...
H. Peyret, S. N. Shah, Y. Meshcheriakova, J.‐W. Jung, K. Saunders, G. P. Lomonossoff   +5 more
wiley   +1 more source

Discovery of an antibody for pan-ebolavirus therapy [PDF]

Scientific Reports, 2016
AbstractDuring the latest outbreak of Ebola virus disease in West Africa, monoclonal antibody therapy (e.g., ZMapp) was utilized to treat patients. However, due to the antigenic differences among the five ebolavirus species, the current therapeutic monoclonal antibodies are only effective against viruses of the species Zaire ebolavirus.
Furuyama, Wakako, Marzi, Andrea, Nanbo, Asuka, Haddock, Elaine, Maruyama, Junki, Miyamoto, Hiroko, Igarashi, Manabu, Yoshida, Reiko, Noyori, Osamu, Feldmann, Heinz, Takada, Ayato   +10 more
openaire   +3 more sources

Ebola virus disease outbreak in Korea: use of a mathematical model and stochastic simulation to estimate risk [PDF]

Epidemiology and Health, 2019
OBJECTIVES According to the World Health Organization, there have been frequent reports of Ebola virus disease (EVD) since the 2014 EVD pandemic in West Africa. We aim to estimate the outbreak scale when an EVD infected person arrives in Korea.
Youngsuk Ko, Seok-Min Lee, Soyoung Kim, Moran Ki, Eunok Jung   +4 more
doaj   +1 more source

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry

mBio, 2019
Ebola virus (EBOV) causes highly lethal disease outbreaks against which no FDA-approved countermeasures are available. Although many host factors exploited by EBOV for cell entry have been identified, including host cell surface phosphatidylserine ...
J. Maximilian Fels, Jennifer S. Spence, Robert H. Bortz, Zachary A. Bornholdt, Kartik Chandran   +4 more
doaj   +1 more source

Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors

mAbs, 2020
Ebola virus (EBOV) can cause severe hemorrhagic fever in humans, and no approved treatment is currently available. Although several antibodies have achieved good protection in animal models, the potential emerging isolates of ebolavirus and the unknown ...
Pengfei Fan, Xiangyang Chi, Guodong Liu, Guanying Zhang, Zhengshan Chen, Yujiao Liu, Ting Fang, Jianmin Li, Logan Banadyga, Shihua He, Changming Yu, Xiangguo Qiu, Wei Chen   +12 more
doaj   +1 more source