Results 51 to 60 of about 8,175 (207)

Immunogenicity and safety of Ebola virus vaccines in healthy adults: a systematic review and network meta-analysis

Human Vaccines & Immunotherapeutics, 2021
Clinical development of Ebola virus vaccines (EVV) was accelerated by the West African Ebola virus epidemic which remains the deadliest in history. To compare and rank the EVV according to their immunogenicity and safety.
Alhassane Diallo, Miguel Carlos-Bolumbu, Minerva Cervantes-Gonzalez, Veronika Wozniak, Mamadou Hassimiou Diallo, Boubacar Djelo Diallo, Alexandre Delamou, Florence Galtier   +7 more
doaj   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade, Rhiannon Potter, Alex Inskip, Jane Nesworthy, Kirsti Brock, Gill Norman   +5 more
wiley   +1 more source

Investigation of Ebolavirus exposure in pigs presented for slaughter in Uganda [PDF]

, 2021
In 2008, an outbreak ofReston ebolavirus(RESTV) in pigs in the Philippines expanded our understanding of the host range of ebolaviruses. Subsequent experimental infections with the human-pathogenic speciesZaire ebolavirus(EBOV) confirmed that pigs are ...
Ndoboli, Dickson, Fischer, Kerstin, Roesel, Kristina, Smith, Greg, Weingartl, Hana, Ward, Michael P., Atherstone, Christine, Diederich, Sandra, Casey, Graham, Pickering, Bradley   +9 more
core   +1 more source

Virological diagnosis of Ebolavirus infection

Pathology, 2015
Ebolaviruses, and the other viral causes of haemorrhagic fevers (VHF) have always posed special problems for diagnostic laboratories. These arise from the rarity of human infections, minimal documented experience with test delivery and interpretation, the paucity of established commercial or in-house assays, the lack of clinical material for test ...
Smith, D.W., Rawlinson, W.D., Kok, J., Dwyer, D.E., Catton, M.   +4 more
openaire   +2 more sources

Repurpose an FDA‐Approved Antibody Using DARPin‐Scaffolded Bridge Protein

Chemistry–Methods, Volume 6, Issue 5, May 2026.
The cell line and scalable upstream/downstream process development needed for every new monoclonal antibody are both highly expensive and time‐consuming, significantly increasing the cost of new antibody therapeutics. By contrast, the production of many synthetic binders can be accomplished rapidly and with lower production costs.
Michael Woolley, Joshua D. Bryant, Samuel Vrana, Karuppiah Chockalingam, Zhilei Chen   +4 more
wiley   +1 more source

Ebolavirus Evolution: Past and Present

PLOS Pathogens, 2015
(Uploaded by Plazi for the Bat Literature Project) The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time ...
De La Vega, Marc-Antoine, Stein, Derek, Kobinger, Gary P, Hobman, Tom C.   +3 more
openaire   +5 more sources

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Ebolavirus Classification Based on Natural Vectors [PDF]

DNA and Cell Biology, 2015
According to the WHO, ebolaviruses have resulted in 8818 human deaths in West Africa as of January 2015. To better understand the evolutionary relationship of the ebolaviruses and infer virulence from the relationship, we applied the alignment-free natural vector method to classify the newest ebolaviruses.
Hui, Zheng, Changchuan, Yin, Tung, Hoang, Rong Lucy, He, Jie, Yang, Stephen S-T, Yau   +5 more
openaire   +2 more sources

Comparative Analysis of the Sequenced Zaire ebolavirus Samples from the Republic of Guinea

Проблемы особо опасных инфекций, 2015
An unprecedented on its scale Ebola fever epidemic, caused by Zaire ebolavirus, has been registered in the territory of West Africa in 2014-2015. The virus quickly spread from the Republic of Guinea into the neighboring countries.
Ya. M. Krasnov, V. A. Safronov, N. Yu. Nosov, V. V. Kutyrev, A. Yu. Popova   +4 more
doaj   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source