Results 1 to 10 of about 2,529,949 (162)

Single-dose VSV-based vaccine protects cynomolgus macaques from disease after Taï Forest virus infection [PDF]

Emerging Microbes and Infections, 2023
Taï Forest virus (TAFV) is a lesser-known ebolavirus that causes lethal infections in chimpanzees and is responsible for a single human case. Limited research has been done on this human pathogen; however, with the recent emergence of filoviruses in West
Paige Fletcher, Kyle L. O’Donnell, Brianna M. Doratt, Delphine C. Malherbe, Chad S. Clancy, Joseph F. Rhoderick, Friederike Feldmann, Patrick W. Hanley, Thomas G. Ksiazek, Thomas W. Geisbert, Ilhem Messaoudi, Andrea Marzi   +11 more
doaj   +5 more sources

Taï Forest Virus Does Not Cause Lethal Disease in Ferrets [PDF]

Microorganisms, 2021
Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates.
Zachary Schiffman, Feihu Yan, Shihua He, Kevin Tierney, Wenjun Zhu, Karla Emeterio, Huajun Zhang, Logan Banadyga, Xiangguo Qiu   +8 more
doaj   +3 more sources

Pathogenic differences of cynomolgus macaques after Taï Forest virus infection depend on the viral stock propagation. [PDF]

PLoS Pathogens
Taï Forest virus (TAFV) is a negative-sense RNA virus in the Filoviridae family. TAFV has caused only a single human infection, but several disease outbreaks in chimpanzees have been linked to this virus.
Paige Fletcher, Chad S Clancy, Kyle L O'Donnell, Brianna M Doratt, Delphine C Malherbe, Joseph F Rhoderick, Friederike Feldmann, Patrick W Hanley, Ayato Takada, Ilhem Messaoudi, Andrea Marzi   +10 more
doaj   +3 more sources

Mucosal Taï Forest virus infection causes disease in ferrets. [PDF]

PLoS Pathogens
The filovirus Taï Forest virus (TAFV) caused a single human case of infection originating from a chimpanzee outbreak, demonstrating that humans are susceptible to TAFV infection.
Paige Fletcher, Kyle L O'Donnell, Joseph F Rhoderick, Corey W Henderson, Atsushi Okumura, Trenton Bushmaker, Kathleen Cordova, Greg Saturday, Andrea Marzi   +8 more
doaj   +2 more sources

Filovirus reactive antibodies in wildlife hunting communities suggest ongoing zoonotic spillover in forested Guinea [PDF]

Nature Communications
Forested Guinea has been the site of multiple high-consequence viral spillover events, including the index case of the 2013-16 West African Ebola epidemic.
Grace Hood, Joseph Akoi Bore, Tom Tipton, Zézé Onivogui, Koly Sovogui, Kpadè Zézé Zoumanigui, Joseph Timothy, McKenna Roe, Lianying Yan, Simon Scott, Nigel Temperton, Edward Wright, Gwenda Hughes, Sanaba Boumbaly, Eric D. Laing, N’Faly Magassouba, Kimberly Fornace, Miles Carroll   +17 more
doaj   +2 more sources

Homologous and heterologous protection of nonhuman primates by Ebola and Sudan virus-like particles.

PLoS ONE, 2015
Filoviruses cause hemorrhagic fever resulting in significant morbidity and mortality in humans. Several vaccine platforms that include multiple virus-vectored approaches and virus-like particles (VLPs) have shown efficacy in nonhuman primates.
Kelly L Warfield, John M Dye, Jay B Wells, Robert C Unfer, Frederick W Holtsberg, Sergey Shulenin, Hong Vu, Dana L Swenson, Sina Bavari, M Javad Aman   +9 more
doaj   +2 more sources

Recombinant Bombali ebolavirus in cynomolgus macaques as a survival model of Ebola virus disease [PDF]

Nature Communications
Ebolaviruses are known to cause severe hemorrhagic fever in humans. A new ebolavirus species, Bombali orthoebolavirus (BOMV), was recently detected in bats from Sierra Leone, Kenya, Guinea, Mozambique, and Tanzania.
Jacquelyn Turcinovic, Karla A. Fenton, Krystle N. Agans, Viktoriya Borisevich, Daniel J. Deer, Joan B. Geisbert, Rachel O’Toole, Dafna Abelson, Natalie S. Dobias, Abhishek N. Prasad, Courtney Woolsey, John H. Connor, César G. Albariño, Thomas W. Geisbert, Robert W. Cross   +14 more
doaj   +2 more sources

Synthetic recovery of Yada Yada virus expands insect-specific alphavirus knowledge and facilitates production of chimeric viruses

npj Viruses
Few insect-specific alphaviruses (ISA) have been discovered, with even fewer culturable to facilitate full characterisation. Here, we report the recovery of an infectious clone of Yada Yada virus (YYV)—a virus previously only detected by metagenomic ...
Mikaela G. Bell, Rhys H. Parry, Tricia S. E. Lee, Gervais Habarugira, Isabella E. McMahon, Madeline A. Thompson, Naphak Modhiran, Daniel Watterson, Jana Batovska, Stacey E. Lynch, Roy A. Hall, Jessica J. Harrison, Jody Hobson-Peters   +12 more
doaj   +2 more sources

Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity

Virulence, 2021
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%.
Satoko Yamaoka, Hideki Ebihara
doaj   +1 more source

One-Step Reverse-Transcription FRET-PCR for Differential Detection of Five Ebolavirus Species. [PDF]

PLoS ONE, 2015
Ebola is an emerging infectious disease caused by a deadly virus belonging to the family Filoviridae, genus Ebolavirus. Based on their geographical distribution, Ebolavirus has been classified into total five species so far, mainly Zaire, Sudan, Taï ...
Guangwu Lu, Jilei Zhang, Chuntao Zhang, Xiaolu Li, Dawei Shi, Zhaopeng Yang, Chengming Wang   +6 more
doaj   +1 more source