Results 41 to 50 of about 2,529,949 (162)

Leading EBOV vaccines.

, 2021
The most advanced vaccines in the US and Europe include Ervebo (rVSV-EBOV), Zabdeno/Mvabea (Ad26-ZEBOV/MVA-BN-Filo), and cAd3-EBOZ (with or without MVA-BN-Filo). These platforms use a viral vector to provoke an immune response, but, as illustrated, there
Thomas W. Geisbert (9239748), Courtney Woolsey (9254949)   +1 more
core   +1 more source

Ptbp1 Condensates With Phase Separation‐Like Features in Cardiomyocyte Nuclei Regulate Splicing of Proliferative Genes in Neonatal Cardiomyocytes

Development, Growth &Differentiation, Volume 68, Issue 8, October 2026.
Phase‐separated Ptbp1 droplets form molecular complexes containing multiple proliferation‐associated molecules. Ptbp1 granules containing four RNA recognition motifs (RRMs) domains are present in the nuclei of mouse cardiomyocytes specifically during the proliferative stage.
Tai Sada, Akane Sakaguchi, Yoichi Shinkai, Reiko Nakagawa, Chiharu Tanegashima, Mitsutaka Kadota, Takefumi Kondo, Wataru Kimura   +7 more
wiley   +1 more source

Semliki Forest virus induced, immune mediated demyelination: the effect of irradiation [PDF]

, 1987
Intraperitoneal infection with the avirulent A7(74) strain of the alphavirus Semliki Forest virus (SFV) induces an immune mediated demyelinating encephalomyelitis.
Fazakerley, J K, Webb, H E
core  

Recombinant modified vaccinia virus Ankara generating Ebola virus-like particles [PDF]

, 2017
There are currently no approved therapeutics or vaccines to treat or protect against the severe hemorrhagic fever and death caused by Ebola virus (EBOV). Ebola virus-like particles (EBOV VLPs) consisting of the matrix protein VP40, the glycoprotein (GP),
Wolferstätter, Michael, Gert Zimmer, Mark Suter, Michael Wolferstätter, Zimmer, Gert, Steigerwald, Robin, Suter, Mark, Hubertus Hochrein, Andrea S. Laimbacher, Marieken Klingenberg, Robin Steigerwald, Chaplin, Paul, Marc Schweneker, Klingenberg, Marieken, Paul Chaplin, Lauterbach, Henning, Hochrein, Hubertus, Laimbacher, Andrea S, Elisabeth M. Schraner, Schraner, Elisabeth M, Wagner, Susanne, Jürgen Hausmann, Hausmann, Jürgen, Susanne Wagner, Schweneker, Marc, Henning Lauterbach, Ulrike Dirmeier, Dirmeier, Ulrike, Hausmann J, Schraner, Elisabeth M., Zimmer G, Schweneker M, Steigerwald R, Suter M, Dirmeier U, Laimbacher AS, Laimbacher, Andrea S., Schraner EM, Chaplin P, Wolferstätter M, Wagner S, Klingenberg M, Hochrein H, Lauterbach H   +43 more
core   +2 more sources

Ebolavirus replication and Tetherin/BST-2

Frontiers in Microbiology, 2012
Ebolavirus (EBOV) is an enveloped, non-segmented, negative-stranded RNA virus, which consists of five species: Zaire ebolavirus (ZEBOV), Sudan ebolavirus (SEBOV), Tai Forest ebolavirus (TFEBOV), Bundibugyo ebolavirus (BEBOV), and Reston ebolavirus (REBOV)
Jiro eYasuda
doaj   +1 more source

Entdeckung eines antiviralen Elektronentransferprozesses zur Erzeugung katalytisch selbstversorgender viraler Restriktionsfaktoren

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
CYB5R3 wird als mutmaßlicher Elektronentransferpartner von Viperin (RSAD2) identifiziert, was erklärt, warum die ER‐Lokalisation für die antivirale Aktivität erforderlich ist. Dieses Wissen ermöglichte die Entwicklung immunstiller, katalytisch selbstversorgender antiviraler Restriktionsfaktor‐Enzyme (iCAREs), die ein antivirales Nukleosidtriphosphat ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Systemic and Mucosal Immune Responses From Serotype‐Switched Viral‐Vectored Ebola Vaccines

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Ebola virus is a highly virulent pathogen causing severe hemorrhagic fever with 25%–90% mortality. The 2014 outbreak infected over 28,000 people, causing 11,325 deaths. Although there is one FDA‐approved vaccine available for limited use, additional vaccines are needed.
Joshua Wiggins, Adthakorn Madapong, Eric Weaver   +2 more
wiley   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Ebolavirus and Haemorrhagic Syndrome

Sultan Qaboos University Medical Journal, 2015
The Ebola virus is a highly virulent, single-stranded ribonucleic acid virus which affects both humans and apes and has fast become one of the world’s most feared pathogens. The virus induces acute fever and death, with haemorrhagic syndrome occurring in
Gerald A. Matua, Dirk M. Van der Wal, Rozzano C. Locsin   +2 more
doaj   +2 more sources

Machine Learning of Personal Repertoires From Public T Cell Receptors

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT The T‐cell receptor (TCR) repertoire records an individual's immunological history, but most unique CDR3 sequences in any one person are private and uninformative about anyone else. A small subset, however, recurs predictably across unrelated donors.
Or Malca, Alona Zilberberg, Sol Efroni
wiley   +1 more source