Insights into Reston virus spillovers and adaption from virus whole genome sequences. [PDF]
PLoS ONE, 2017 Reston virus (family Filoviridae) is unique among the viruses of the Ebolavirus genus in that it is considered non-pathogenic in humans, in contrast to the other members which are highly virulent.
César G Albariño +6 more
doaj +7 more sources
Differences in Viral RNA Synthesis but Not Budding or Entry Contribute to the In Vitro Attenuation of Reston Virus Compared to Ebola Virus [PDF]
Microorganisms, 2020 Most filoviruses cause severe disease in humans. For example, Ebola virus (EBOV) is responsible for the two most extensive outbreaks of filovirus disease to date, with case fatality rates of 66% and 40%, respectively. In contrast, Reston virus (RESTV) is
Bianca S. Bodmer +7 more
doaj +8 more sources
Risk assessment of Ebola Reston virus in humans in the Philippines [PDF]
Western Pacific Surveillance and Response, 2019 Objective: There have been five documented outbreaks of Ebola Reston virus (RESTV) in animals epidemiologically linked to the Philippines. This assessment was conducted to determine the risk of RESTV occurring in humans in the Philippines and its ...
Johnette A Peñas +4 more
doaj +5 more sources
Reston virus causes severe respiratory disease in young domestic pigs [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The emergence of Reston virus (RESTV) in domestic pigs in the Philippines and, subsequently, the detection of RESTV sequences in pigs in China are serious human and animal health concerns. Food safety is an immediate fear, and pathogenicity and potential for zoonotic transmission are important concerns.
Juergen Richt +2 more
exaly +5 more sources
Comparative pathogenesis of Ebola virus and Reston virus infection in humanized mice [PDF]
JCI Insight, 2019 Filoviruses of the genus Ebolavirus include 6 species with marked differences in their ability to cause disease in humans. From the highly virulent Ebola virus to the seemingly nonpathogenic Reston virus, case fatality rates can range between 0% and 90%.
Susanne Krasemann +2 more
exaly +5 more sources
Sequence of Reston Virus Isolate AZ-1435, an Ebolavirus Isolate Obtained during the 1989–1990 Reston Virus Epizootic in the United States [PDF]
Genome Announcements, 2017 ABSTRACT Reston virus (RESTV) was discovered in 1989–1990 during three connected epizootics of highly lethal viral hemorrhagic fever among captive macaques in primate housing facilities in the United States and Philippines. Currently, only one RESTV isolate from that outbreak (named Pennsylvania) has been sequenced.
Steve Porcella, Reed F Johnson
exaly +5 more sources
Domestic pigs are susceptible to experimental infection with non-human primate-derived Reston virus without the need for adaptation [PDF]
Scientific Reports, 2023 Domestic pigs are a critical component of the food supply and one of the most commonly raised production animals. Pork consumption has driven the intensification of pig production expanding into environments conducive to increased emergence and spread of
Charles E. Lewis +7 more
doaj +4 more sources
Analysis of the humoral immune responses among cynomolgus macaque naturally infected with Reston virus during the 1996 outbreak in the Philippines [PDF]
BMC Veterinary Research, 2012 Background Ebolaviruses induce lethal viral hemorrhagic fevers (VHFs) in humans and non-human primates, with the exceptions of Reston virus (RESTV), which is not pathogenic for humans.
Taniguchi Satoshi +14 more
doaj +5 more sources
Molecular evidence of Ebola Reston virus infection in Philippine bats. [PDF]
Virol J, 2015 In 2008-09, evidence of Reston ebolavirus (RESTV) infection was found in domestic pigs and pig workers in the Philippines. With species of bats having been shown to be the cryptic reservoir of filoviruses elsewhere, the Philippine government, in conjunction with the Food and Agriculture Organization of the United Nations, assembled a multi-disciplinary
Jayme SI +20 more
europepmc +5 more sources
Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver. [PDF]
J Infect Dis, 2017 Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection, pronounced weight loss and markers of hepatic damage ...
Spengler JR +8 more
europepmc +5 more sources