Results 11 to 20 of about 1,367,842 (200)

A SOME ECOLOGICAL CHARACTERISTICS OF EBOLA VIRUS IN NATURAL FOCIES [PDF]

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Ebola virus that composed Ebolavirus genus of Filoviridae Family causes severe hemorrhagic fever in humans with high case-fatality rates (up to 90%).
T. E. Sizikova, V. N. Lebedev, N. V. Karulina, O. V. Chukhralya, S. I. Syromyatnikova, S. V. Borisevich   +5 more
doaj   +2 more sources

Comparative pathogenesis of Ebola virus and Reston virus infection in humanized mice. [PDF]

JCI Insight, 2019
Filoviruses of the genus Ebolavirus include 6 species with marked differences in their ability to cause disease in humans. From the highly virulent Ebola virus to the seemingly nonpathogenic Reston virus, case fatality rates can range between 0% and 90%.
Escudero-Pérez B, Ruibal P, Rottstegge M, Lüdtke A, Port JR, Hartmann K, Gómez-Medina S, Müller-Guhl J, Nelson EV, Krasemann S, Rodríguez E, Muñoz-Fontela C.   +11 more
europepmc   +4 more sources

Sequence of Reston Virus Isolate AZ-1435, an Ebolavirus Isolate Obtained during the 1989-1990 Reston Virus Epizootic in the United States. [PDF]

Genome Announc, 2017
ABSTRACT Reston virus (RESTV) was discovered in 1989–1990 during three connected epizootics of highly lethal viral hemorrhagic fever among captive macaques in primate housing facilities in the United States and Philippines. Currently, only one RESTV isolate from that outbreak (named Pennsylvania) has been sequenced.
Cornish JP, Diaz L, Ricklefs SM, Kanakabandi K, Sword J, Jahrling PB, Kuhn JH, Porcella SF, Johnson RF.   +8 more
europepmc   +4 more sources

Molecular evidence of Ebola Reston virus infection in Philippine bats. [PDF]

Virol J, 2015
In 2008-09, evidence of Reston ebolavirus (RESTV) infection was found in domestic pigs and pig workers in the Philippines. With species of bats having been shown to be the cryptic reservoir of filoviruses elsewhere, the Philippine government, in conjunction with the Food and Agriculture Organization of the United Nations, assembled a multi-disciplinary
Jayme SI, Field HE, de Jong C, Olival KJ, Marsh G, Tagtag AM, Hughes T, Bucad AC, Barr J, Azul RR, Retes LM, Foord A, Yu M, Cruz MS, Santos IJ, Lim TM, Benigno CC, Epstein JH, Wang LF, Daszak P, Newman SH.   +20 more
europepmc   +5 more sources

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver. [PDF]

J Infect Dis, 2017
Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection, pronounced weight loss and markers of hepatic damage ...
Spengler JR, Saturday G, Lavender KJ, Martellaro C, Keck JG, Nichol ST, Spiropoulou CF, Feldmann H, Prescott J.   +8 more
europepmc   +5 more sources

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan. [PDF]

Pharmacol Res Perspect
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Akinbolade S, Potter R, Inskip A, Nesworthy J, Brock K, Norman G.   +5 more
europepmc   +2 more sources

Epidemiology of Ebola (Subtype Reston) Virus in the Philippines, 1996 [PDF]

The Journal of Infectious Diseases, 1999
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
M E, Miranda, T G, Ksiazek, T J, Retuya, A S, Khan, A, Sanchez, C F, Fulhorst, P E, Rollin, A B, Calaor, D L, Manalo, M C, Roces, M M, Dayrit, C J, Peters   +11 more
openaire   +3 more sources

Novel triplex nucleic acid lateral flow immunoassay for rapid detection of Nipah virus, Middle East respiratory syndrome coronavirus and Reston ebolavirus

Animal Diseases
We report the development of a triplex nucleic acid lateral flow immunoassay (NALFIA) for the detection of the genomes of Nipah virus (NiV), Middle East respiratory syndrome coronavirus (MERS-CoV) and Reston ebolavirus (REBOV), which are intended for ...
Santhalembi Chingtham, Diwakar D. Kulkarni, Sumi Sivaraman, Anamika Mishra, Atul K. Pateriya, Vijendra Pal Singh, Ashwin Ashok Raut   +6 more
doaj   +2 more sources

Systemic and Mucosal Immune Responses From Serotype-Switched Viral-Vectored Ebola Vaccines. [PDF]

J Med Virol
ABSTRACT Ebola virus is a highly virulent pathogen causing severe hemorrhagic fever with 25%–90% mortality. The 2014 outbreak infected over 28,000 people, causing 11,325 deaths. Although there is one FDA‐approved vaccine available for limited use, additional vaccines are needed.
Wiggins J, Madapong A, Weaver E.
europepmc   +2 more sources

Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity

Virulence, 2021
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%.
Satoko Yamaoka, Hideki Ebihara
doaj   +1 more source