Results 11 to 20 of about 2,511 (120)
PLoS ONE, 2022 BackgroundThough clinically similar, Ebola virus disease and Marburg virus disease are caused by different viruses. Of the 30 documented outbreaks of these diseases in sub-Saharan Africa, eight were major outbreaks (≥200 cases; five caused by Zaire ...
Viki Bockstal +17 more
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Frontiers in Cell and Developmental Biology, 2021 Alphaviruses infect a diverse range of host organisms including mosquitoes, mammals, and birds. The enigmatic alphavirus non-structural protein 3 (nsP3) has an intrinsically disordered, C-terminal hypervariable domain (HVD) that can interact with a ...
Gwen Nowee +6 more
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Natural history of Sudan ebolavirus infection in rhesus and cynomolgus macaques
Emerging Microbes and Infections, 2022 Due to its high mortality rate and continued re-emergence, Ebolavirus disease (EVD) continues to pose a serious threat to global health. A group of viruses within the genus Ebolavirus causes this severe hemorrhagic disease in humans: Ebola virus (EBOV ...
Courtney Woolsey +10 more
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Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing. [PDF]
PLoS ONE, 2014 A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus allowing for appropriate therapeutic and containment procedures.
Jeffrey W Koehler +10 more
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A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates. [PDF]
PLoS ONE, 2018 The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections.
Benoit Callendret +20 more
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Structural Basis for Differential Neutralization of Ebolaviruses
Viruses, 2012 There are five antigenically distinct ebolaviruses that cause hemorrhagic fever in humans or non-human primates (Ebola virus, Sudan virus, Reston virus, Taï Forest virus, and Bundibugyo virus).
John M. Dye +11 more
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STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV)
Viruses, 2021 Currently there is no FDA-licensed vaccine or therapeutic against Sudan ebolavirus (SUDV) infections. The largest ever reported 2014–2016 West Africa outbreak, as well as the 2021 outbreak in the Democratic Republic of Congo, highlight the critical need ...
Olivier Escaffre +12 more
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Generation and Characterization of Anti-Filovirus Nucleoprotein Monoclonal Antibodies
Viruses, 2019 Filoviruses cause lethal hemorrhagic fever in humans. The filovirus nucleoprotein (NP) is expressed in high abundance in infected cells and is essential for virus replication.
Md Niaz Rahim +8 more
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Viruses, 2015 The Egyptian rousette bat (Rousettus aegyptiacus) is a natural reservoir for marburgviruses and a consistent source of virus spillover to humans. Cumulative evidence suggests various bat species may also transmit ebolaviruses.
Megan E.B. Jones +6 more
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10061 Assessing immunogenicity of an Ebola vaccine in humans using a systems biology approach
Journal of Clinical and Translational Science, 2021 IMPACT: Understanding gene expression changes after viral vaccination and booster may help predict vaccine efficacy. OBJECTIVES/GOALS: Utilize a systems biology approach to identify gene expression changes after administration of Zaire Ebola virus ...
Olivia Martin +4 more
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