Results 11 to 20 of about 6,334 (171)

Ebolavirus:

Revista Gestão & Saúde, 2015
O atual surto de ebola tem devastado centenas de vidas, preocupando a comunidade cientifica devido à alta letalidade e difícil controle. Objetivamos observar quais os principais desafios para o controle do vírus e entender a importância de uma gestão ...
Rachid Figueirôa Souza, Aline Rafaela da Silva Rodrigues Machado, Julie Massayo Maeda Oda, Odanir Garcia Guerra, Alex Martins Machado   +4 more
doaj   +4 more sources

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan. [PDF]

Pharmacol Res Perspect
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Akinbolade S, Potter R, Inskip A, Nesworthy J, Brock K, Norman G.   +5 more
europepmc   +2 more sources

In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP-40. [PDF]

Biomed Res Int
The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola virus.
Omara B, Kiyimba K, Fofana FG, Diabaté O, Odur W, Jjingo D, Iramiot JS, Draleru P, Achia J, Shafiq M, Ul-Haq Z, Okella H, Odongo S.   +12 more
europepmc   +2 more sources

Ebolavirus’s Foibles [PDF]

Cell, 2017
Ebola virus disease poses a global health threat. Here, two studies by Wec et al. and Zhao et al. identified vulnerability in an internal fusion loop of an ebolavirus glycoprotein. Monoclonal antibodies elicited from immunization and isolated from a human survivor that recognized epitopes in this area neutralized all five ebolaviruses, guiding the ...
Seiya, Yamayoshi, Yoshihiro, Kawaoka
openaire   +2 more sources

Development and validation of portable, field-deployable Ebola virus point-of-encounter diagnostic assay for wildlife surveillance

One Health Outlook, 2021
Early detection of Ebola virus spillover into wildlife is crucial for rapid response. We developed and validated a portable, cold-chain independent Ebola virus RT-qPCR assay.
Dania M. Figueroa, Eeva Kuisma, M. Jeremiah Matson, Alain U. Ondzie, Trent Bushmaker, Stephanie N. Seifert, Francine Ntoumi, Beatriz Escudero-Pérez, César Muñoz-Fontela, Chris Walzer, Sarah H. Olson, Cynthia Goma-Nkoua, Jean-Vivien Mombouli, Robert J. Fischer, Vincent J. Munster   +14 more
doaj   +1 more source

Ebolaviruscomparative genomics [PDF]

FEMS Microbiology Reviews, 2015
(Uploaded by Plazi for the Bat Literature Project) The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine the dynamics of this genome, we compare more than 100 currently available ebolavirus genomes to each other and to other viral genomes.
Jun, Se Ran, Leuze, Michael R., Nookaew, Intawat, Uberbacher, Edward C., Land, Miriam, Zhang, Qian, Wanchai, Visanu, Chai, Juanjuan, Nielsen, Morten, Trolle, Thomas, Lund, Ole, Buzard, Gregory S., Pedersen, Thomas D., Wassenaar, Trudy M., Ussery, David W.   +14 more
openaire   +3 more sources

Resurgence of Ebola in Uganda: Response Strategies, Lessons Learned, and Future Directions. [PDF]

Health Sci Rep
ABSTRACT Introduction The recent resurgence of Ebola virus disease (EVD), specifically the Sudan virus strain, in Uganda highlights the ongoing threat of emerging infectious diseases. This article aims to analyze the multifaceted factors contributing to this resurgence, evaluate the public health impact, and assess the effectiveness of response ...
Edward M, Muhigi S, Mundua J, Ally A.
europepmc   +2 more sources

Tracking ebolavirus genomic drift with a resequencing microarray.

PLoS ONE, 2022
Filoviruses are emerging pathogens that cause acute fever with high fatality rate and present a global public health threat. During the 2013-2016 Ebola virus outbreak, genome sequencing allowed the study of virus evolution, mutations affecting ...
Irina Tiper, Moussa Kourout, Bryan Lanning, Carolyn Fisher, Krishnamurthy Konduru, Anjan Purkayastha, Gerardo Kaplan, Robert Duncan   +7 more
doaj   +1 more source

Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry [PDF]

Journal of Virology, 2011
ABSTRACT With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and “cuevaviruses”) cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP 1,2 , to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion.
Sheli R, Radoshitzky, Kelly L, Warfield, Xiaoli, Chi, Lian, Dong, Krishna, Kota, Steven B, Bradfute, Jacqueline D, Gearhart, Cary, Retterer, Philip J, Kranzusch, John N, Misasi, Marc A, Hogenbirk, Victoria, Wahl-Jensen, Viktor E, Volchkov, James M, Cunningham, Peter B, Jahrling, M Javad, Aman, Sina, Bavari, Michael, Farzan, Jens H, Kuhn   +18 more
openaire   +2 more sources

Epidemiology of Ebolaviruses from an Etiological Perspective

Pathogens, 2023
Since the inception of the ebolavirus in 1976, 32 outbreaks have resulted in nearly 15,350 deaths in more than ten countries of the African continent. In the last decade, the largest (2013–2016) and second largest (2018–2020) ebolavirus outbreaks have ...
Sahil Jain, Svetlana Khaiboullina, Ekaterina Martynova, Sergey Morzunov, Manoj Baranwal   +4 more
doaj   +1 more source