Filoviruses are ancient and integrated into mammalian genomes [PDF]
BMC Evolutionary Biology, 2010 Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy +2 more
doaj +3 more sources
One-for-one or one-for-all? Considerations for filovirus vaccine development. [PDF]
PLoS BiologyFiloviruses continue to re-emerge in Africa, causing localized public health emergencies. Although vaccination has slowly been implemented for Ebola virus, not for other filoviruses, holistic approaches are needed to broadly protect against filovirus ...
Andrea Marzi
doaj +2 more sources
Novel filoviruses: indication of a global threat or cause to reassess our risk perception? [PDF]
npj VirusesFiloviruses such as Ebola virus are widely known as causative agents of severe human disease, although apathogenic filoviruses also exist. There is now increasing evidence that filoviruses circulate in almost all parts of the world, where they are being ...
Allison Groseth, Thomas Hoenen
doaj +2 more sources
Serologic Evidence of Fruit Bat Exposure to Filoviruses, Singapore, 2011–2016
Emerging Infectious Diseases, 2018 To determine whether fruit bats in Singapore have been exposed to filoviruses, we screened 409 serum samples from bats of 3 species by using a multiplex assay that detects antibodies against filoviruses.
Ian H Mendenhall +2 more
exaly +3 more sources
Non-Ebola Filoviruses: Potential Threats to Global Health Security [PDF]
VirusesFiloviruses are negative-sense single-stranded RNA viruses often associated with severe and highly lethal hemorrhagic fever in humans and nonhuman primates, with case fatality rates as high as 90%.
Yannick Munyeku-Bazitama +2 more
doaj +2 more sources
Genetics-Based Classification of Filoviruses Calls for Expanded Sampling of Genomic Sequences
Viruses, 2012 We have recently developed a computational approach for hierarchical, genome-based classification of viruses of a family (DEmARC). In DEmARC, virus clusters are delimited objectively by devising a universal family-wide threshold on intra-cluster genetic ...
Chris Lauber, Alexander E Gorbalenya
exaly +3 more sources
Virucidal Approaches for Hemorrhagic Fever Viruses [PDF]
VirusesWe have reviewed the primary literature on the virucidal efficacy of microbicidal active ingredients, formulated microbicides, and physical inactivation approaches (heat, irradiation) for hemorrhagic fever viruses (HFVs) (arenaviruses, filoviruses ...
Raymond W. Nims, M. Khalid Ijaz
doaj +2 more sources
The New Members of Filoviridae Family: Distribution, Natural Reservoirs, Potential Epidemic Danger
Вестник войск РХБ защиты, 2023 The purpose of the work is to analyze the distribution, natural reservoirs and potential epidemic hazard of new members of the Filoviridae family – Bombali viruses (genus Ebolavirus), Lloviu (genus Cuevavirus), Mengla (genus Dianlovirus), Xylang (genus ...
T. E. Sizikova +4 more
doaj +1 more source
Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines
Pathogens, 2022 Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu +2 more
doaj +1 more source
Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia
Viruses, 2021 Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as ...
Katendi Changula +9 more
doaj +1 more source