Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines
Pathogens, 2022 Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu +2 more
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One-for-one or one-for-all? Considerations for filovirus vaccine development. [PDF]
PLoS BiologyFiloviruses continue to re-emerge in Africa, causing localized public health emergencies. Although vaccination has slowly been implemented for Ebola virus, not for other filoviruses, holistic approaches are needed to broadly protect against filovirus ...
Andrea Marzi
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Novel filoviruses: indication of a global threat or cause to reassess our risk perception? [PDF]
npj VirusesFiloviruses such as Ebola virus are widely known as causative agents of severe human disease, although apathogenic filoviruses also exist. There is now increasing evidence that filoviruses circulate in almost all parts of the world, where they are being ...
Allison Groseth, Thomas Hoenen
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Genetics-Based Classification of Filoviruses Calls for Expanded Sampling of Genomic Sequences
Viruses, 2012 We have recently developed a computational approach for hierarchical, genome-based classification of viruses of a family (DEmARC). In DEmARC, virus clusters are delimited objectively by devising a universal family-wide threshold on intra-cluster genetic ...
Alexander E Gorbalenya, Chris Lauber
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VaccinesBackground/Objectives: Orthoebolaviruses and orthomarburgviruses are filoviruses that can cause viral hemorrhagic fever and significant morbidity and mortality in humans.
Marija Zaric +2 more
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The New Members of Filoviridae Family: Distribution, Natural Reservoirs, Potential Epidemic Danger
Вестник войск РХБ защиты, 2023 The purpose of the work is to analyze the distribution, natural reservoirs and potential epidemic hazard of new members of the Filoviridae family – Bombali viruses (genus Ebolavirus), Lloviu (genus Cuevavirus), Mengla (genus Dianlovirus), Xylang (genus ...
T. E. Sizikova +4 more
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Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia
Viruses, 2021 Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as ...
Katendi Changula +9 more
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Animal Model Alternatives in Filovirus and Bornavirus Research
Viruses, 2023 The order Mononegavirales contains a variety of highly pathogenic viruses that may infect humans, including the families Filoviridae, Bornaviridae, Paramyxoviridae, and Rhabodoviridae.
Lina Widerspick +3 more
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The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent. [PDF]
PLoS ONE, 2016 Ebola and marburgviruses, members of the family Filoviridae, can cause severe hemorrhagic fever in humans. The ongoing Ebola virus (EBOV) disease epidemic in Western Africa claimed more than 11,300 lives and was associated with secondary cases outside ...
Markus Hoffmann +4 more
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Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
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