Results 31 to 40 of about 6,447 (198)

Intracellular Events and Cell Fate in Filovirus Infection

Viruses, 2011
Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood
Elena Ryabchikova, Ronald B. Corley, Elke Mühlberger, Judith Olejnik   +3 more
doaj   +1 more source

Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017

, 2021
European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of European perch remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting a ...
Seuberlich, Torsten, Melanie Rupp, Nicholas Di Paola, Hierweger, Melanie M., Rémy Bruggmann, Jens H. Kuhn, Hierweger, Melanie M, Michel C. Koch, Schmidt-Posthaus, Heike, Piet Maes, Maes, Piet, Torsten Seuberlich, Bruggmann, Remy, Melanie M. Hierweger, Heike Schmidt-Posthaus, Di Paola, Nicholas, Rupp, Melanie, Koch, Michel C, Koch, Michel C., Kuhn, Jens H., Kuhn, Jens H   +20 more
core   +1 more source

Remdesivir inhibits the polymerases of the novel filoviruses lloviu and Bombali virus

, 2021
In recent years, a number of novel filoviruses (e.g. Lloviu virus (LLOV) and Bombali virus (BOMV)) have been discovered. While antibody-based therapeutics have recently been approved for treatment of infections with the filovirus Ebola virus (EBOV), no ...
Wendt, Lisa, Bodmer, Bianca Susanne, Groseth, Allison, Zierke, Lukas, Hoenen, Thomas, Greßler, Josephin   +5 more
core   +1 more source

Maternal Immunization Using a Protein Subunit Vaccine Mediates Passive Immunity against Zaire ebolavirus in a Murine Model

Viruses, 2022
The Ebola virus has caused outbreaks in Central and West Africa, with high rates of morbidity and mortality. Clinical trials of recombinant virally vectored vaccines did not explicitly include pregnant or nursing women, resulting in a gap in knowledge of
Caitlin A. Williams, Teri Ann S. Wong, Aquena H. Ball, Michael M. Lieberman, Axel T. Lehrer   +4 more
doaj   +1 more source

Differentiation of filoviruses by electron microscopy [PDF]

Virus Research, 1995
Cultured monolayers of MA-104, Vero 76, SW-13, and DBS-FRhL-2 cells were infected with Marburg (MBG), Ebola-Sudan (EBO-S), Ebola-Zaire (EBO-Z), and Ebola-Reston (EBO-R) viruses (Filoviridae, Filovirus) and examined by electron microscopy to provide ultrastructural details of morphology and morphogenesis of these potential human pathogens.
Geisbert, T. W., Jahrling, P. B.
openaire   +3 more sources

AAV Vectored Immunoprophylaxis for Filovirus Infections

Tropical Medicine and Infectious Disease, 2020
Filoviruses are among the deadliest infectious agents known to man, causing severe hemorrhagic fever, with up to 90% fatality rates. The 2014 Ebola outbreak in West Africa resulted in over 28,000 infections, demonstrating the large-scale human health and
Amira D. Rghei, Laura P. van Lieshout, Lisa A. Santry, Matthew M. Guilleman, Sylvia P. Thomas, Leonardo Susta, Khalil Karimi, Byram W. Bridle, Sarah K. Wootton   +8 more
doaj   +1 more source

Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.

PLoS Neglected Tropical Diseases, 2019
Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission.
Pilot Dovih, Eric D Laing, Yihui Chen, Dolyce H W Low, B R Ansil, Xinglou Yang, Zhengli Shi, Christopher C Broder, Gavin J D Smith, Martin Linster, Uma Ramakrishnan, Ian H Mendenhall   +11 more
doaj   +1 more source

Filoviruses are ancient and integrated into mammalian genomes

BMC Evolutionary Biology, 2010
Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy, Leach Robert W, Taylor Derek J   +2 more
doaj   +1 more source

Ebola Virus IgG Seroprevalence in Southern Mali

Emerging Infectious Diseases, 2021
Mali had 2 reported introductions of Ebola virus (EBOV) during the 2013–2016 West Africa epidemic. Previously, no evidence for EBOV circulation was reported in Mali. We performed an EBOV serosurvey study in southern Mali.
Sidy Bane, Kyle Rosenke, Ousmane Maiga, Friederike Feldmann, Kimberly Meade-White, Julie Callison, David Safronetz, Nafomon Sogoba, Heinz Feldmann   +8 more
doaj   +1 more source

Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa [PDF]

, 2015
Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in 71 ...
Mweene, Aaron, Nambota, Andrew, Nakamura, Ichiro, Thomas, Yuka, Katampi, Jackson, Matsuno, Keita, Moonga, Ladslav, Sugimoto, Chihiro, Takada, Ayato, Changula, Katendi, Ogawa, Hirohito, Hang'ombe, Bernard, Ito, Kimihito, Simulundu, Edgar, Feldmann, Heinz, Kuroda, Makoto, Yoshida, Reiko, Namangala, Boniface, Muramatsu, Mieko, Nao, Naganori, Maruyama, Junki, Igarashi, Manabu, Ishii, Akihiro, Nakagawa, Emiko, Miyamoto, Hiroko, Nakayama, Eri, Sawa, Hirofumi, Kajihara, Masahiro   +27 more
core   +1 more source