Results 51 to 60 of about 5,390 (165)

Production of human cathepsins using Expi293™ mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of antivirals targeting cysteine proteases will emerge.
Zoe Turner, Elena Arutyunova, Duong T. Bui, Ling Han, Appan Srinivas Kandadai, Bing Bai, Howard S. Young, Lara K. Mahal, John S. Klassen, M. Joanne Lemieux   +9 more
wiley   +1 more source

The vaccines based on the replicon of the venezuelan equine encephalomyelitis virus against viral hemorrhagic fevers

Вопросы вирусологии, 2015
The status of the various recombinant DNA and RNA-derived candidate vaccines, as well as the Venezuelan equine encephalomyelitis virus (VEEV) replicon vaccine system against extremely hazardous viral hemorrhagic fevers, were reviewed.
A. A. Petrov, T. M. Plekhanova, O. N. Sidorova, S. V. Borisevich, A. A. Makhlay   +4 more
doaj  

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, Volume 58, Issue 11, November 2025.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology

Annals of the New York Academy of Sciences, Volume 1550, Issue 1, Page 151-172, August 2025.
Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker, Amanda Vicente‐Santos, Ashley B. Reers, B. R. Ansil, Mika O'Shea, Caroline A. Cummings, Alicia J. Roistacher, Rita M. Quintela‐Tizon, Manuela M. T. Pereira, Juniper Rosen, Arinjay Banerjee, Hannah K. Frank   +11 more
wiley   +1 more source

Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
RSV spreads through three main modes of infection: receptor‐dependent infection of free viral particles, syncytia formation, and transmission via actin filaments. CX3CR1, CCR3, and HSPG mediate viral adsorption; the IGF1R signaling pathway facilitates viral internalization by recruiting NCL to the membrane surface, and the RHO GTPase and PI3K signaling
Han Zhang, Zhao Zhang, Yixuan Yang, Jingjing Pei   +3 more
wiley   +1 more source

Laboratory detection and diagnosis of filoviruses

Virologica Sinica, 2011
Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health.
Yun-peng, Wang, Xian-en, Zhang, Hong-ping, Wei   +2 more
openaire   +3 more sources

Outbreak of Marburg Virus Disease, Equatorial Guinea, 2023

Emerging Infectious Diseases
In February 2023, the government of Equatorial Guinea declared an outbreak of Marburg virus disease. We describe the response structure and epidemiologic characteristics, including case-patient demographics, clinical manifestations, risk factors, and ...
Stephanie Ngai, Egmond Samir Evers, Angela Katherine Lao Seoane, George Ameh, Julienne N. Anoko, Céline Barnadas, Mary J. Choi, Janet Diaz, Luca Fontana, Pierre Formenty, Ingrid Hammermeister Nezu, Frédérique Jacquerioz, John Klena, Henry Laurenson-Schafer, Olivier le Polain de Waroux, Anaïs Legand, Raquel Medialdea Carrera, Tatiana Metcalf, Joel Montgomery, Silvia Morreale, María E. Negrón, Justino Obama Nvé, Mitoha Ondo’o Ayekaba, Boris I. Pavlin, Trevor Shoemaker, Yaimara Torres Hernandez, Mabel Varona Venta, Emily Z. Gutierrez, Florentino Abaga Ondo Ndoho   +28 more
doaj   +1 more source

Current State of the Development of Next-Generation Vaccines against Ebola Virus Disease

Проблемы особо опасных инфекций, 2015
Representative of Ebolavirus gender, Filoviridae family, Ebola virus is an etiological agent of particularly dangerous viral fever, the lethality of which comes up to 88 %.
T. E. Sizikova, V. N. Lebedev, S. V. Borisevich, D. A. Kutaev, I. V. Borisevich   +4 more
doaj   +1 more source