Results 61 to 70 of about 5,423 (165)

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Vaccination and transfusion safety at the time of expanding use of live attenuated vaccines

Vox Sanguinis, Volume 121, Issue 7, Page 923-926, July 2026.
Pierre Tiberghien, Pierre Gallian, Virginie de La Taille, Caroline Bacquet, Syria Laperche   +4 more
wiley   +1 more source

In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP‐40

BioMed Research International, Volume 2026, Issue 1, 2026.
The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola virus.
Boniface Omara, Kenedy Kiyimba, Fatoumata G. Fofana, Oudou Diabaté, Walter Odur, Daudi Jjingo, Jacob Stanley Iramiot, Peace Draleru, Joan Achia, Muhammad Shafiq, Zaheer Ul-Haq, Hedmon Okella, Steven Odongo, Swaran J. S. Flora   +13 more
wiley   +1 more source

Integrating Optimal Control and Economic Analysis to Inform Marburg Virus Response: A Comparison of Intervention Packages

Journal of Mathematics, Volume 2026, Issue 1, 2026.
Marburg virus disease is a severe hemorrhagic illness caused by filoviruses that kills roughly half of those it infects, yet no licensed vaccine or specific antiviral treatment currently exists. When an outbreak strikes a resource‐poor region, health officials face an agonizing question: which interventions offer the most protection for the least cost?
Raed Qahiti, Gizachew Kefelew Hailu, Ali H. Hakami, Ahmad Albaity, Shewafera Wondimagegnhu Teklu, Smritijit Sen   +5 more
wiley   +1 more source

A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells

Viruses, 2019
Filoviruses, such as Ebola virus (EBOV) and Marburg virus, are causative agents of unpredictable outbreaks of severe hemorrhagic fevers in humans and non-human primates.
Corina M. Stewart, Stephanie S. Dorion, Marie A. F. Ottenbrite, Nicholas D. LeBlond, Tyler K. T. Smith, Shirley Qiu, Morgan D. Fullerton, Darwyn Kobasa, Marceline Côté   +8 more
doaj   +1 more source

High‐Resolution Mapping of Environmental Suitability for Reported Ebola Spillover Events in Uganda to Inform Surveillance and Preparedness

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Background Uganda experiences recurrent Ebola disease (EBOD) outbreaks, yet national suitability maps often pool virus species or are too coarse for district‐level planning. We aimed to generate species‐resolved, 1 km relative environmental suitability surfaces for reported Ebola spillover events in Uganda; quantify the contribution of environmental ...
George Paasi, Nancy Malaika, Sam Okware, Peter Olupot-Olupot, Priya Gusain   +4 more
wiley   +1 more source

Laboratory detection and diagnosis of filoviruses

Virologica Sinica, 2011
Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health.
Yun-peng, Wang, Xian-en, Zhang, Hong-ping, Wei   +2 more
openaire   +3 more sources

Outbreak of Marburg Virus Disease, Equatorial Guinea, 2023

Emerging Infectious Diseases
In February 2023, the government of Equatorial Guinea declared an outbreak of Marburg virus disease. We describe the response structure and epidemiologic characteristics, including case-patient demographics, clinical manifestations, risk factors, and ...
Stephanie Ngai, Egmond Samir Evers, Angela Katherine Lao Seoane, George Ameh, Julienne N. Anoko, Céline Barnadas, Mary J. Choi, Janet Diaz, Luca Fontana, Pierre Formenty, Ingrid Hammermeister Nezu, Frédérique Jacquerioz, John Klena, Henry Laurenson-Schafer, Olivier le Polain de Waroux, Anaïs Legand, Raquel Medialdea Carrera, Tatiana Metcalf, Joel Montgomery, Silvia Morreale, María E. Negrón, Justino Obama Nvé, Mitoha Ondo’o Ayekaba, Boris I. Pavlin, Trevor Shoemaker, Yaimara Torres Hernandez, Mabel Varona Venta, Emily Z. Gutierrez, Florentino Abaga Ondo Ndoho   +28 more
doaj   +1 more source

Updates in diagnosis and management of Ebola hemorrhagic fever

Journal of Research in Medical Sciences, 2016
Ebola hemorrhagic fever is a lethal viral disease transmitted by contact with infected people and animals. Ebola infection represents a worldwide health threat causing enormous mortality rates and fatal epidemics. Major concern is pilgrimage seasons with
Salah Mohamed El Sayed, Ali A Abdelrahman, Hani Adnan Ozbak, Hassan Abdullah Hemeg, Ali Mohammed Kheyami, Nasser Rezk, Mohamed Baioumy El-Ghoul, Manal Mohamed Helmy Nabo, Yasser Mohamed Fathy   +8 more
doaj   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source