Results 41 to 50 of about 6,447 (198)

Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages

Viruses, 2019
Macrophages are one of the first and also a major site of filovirus replication and, in addition, are a source of multiple cytokines, presumed to play a critical role in the pathogenesis of the viral infection. Some of these cytokines are known to induce
Tzanko S. Stantchev, Autumn Zack-Taylor, Nicholas Mattson, Klaus Strebel, Christopher C. Broder, Kathleen A. Clouse   +5 more
doaj   +1 more source

Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies

Cell Reports, 2021
Summary: Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be broadly neutralizing, but the details of their epitopes and basis for neutralization are ...
Charles D. Murin, Pavlo Gilchuk, Philipp A. Ilinykh, Kai Huang, Natalia Kuzmina, Xiaoli Shen, Jessica F. Bruhn, Aubrey L. Bryan, Edgar Davidson, Benjamin J. Doranz, Lauren E. Williamson, Jeffrey Copps, Tanwee Alkutkar, Andrew I. Flyak, Alexander Bukreyev, James E. Crowe, Jr., Andrew B. Ward   +16 more
doaj   +1 more source

IFITM3 Is Elevated in BAL and Plasma Following Infection in ICU Setting

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
IFITM3 levels in BAL and plasma of critically ill patients. ABSTRACT Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein with emerging roles in regulating inflammatory pathways. Although much is known about the role of IFITM3 in mediating host antiviral defense, its contribution to systemic immune responses during critical ...
Srabani Das, Carleen R. Spitzer, Paul Consiglio, Matthew C. Exline, Anasuya Sarkar   +4 more
wiley   +1 more source

Forty-Five Years of Marburg Virus Research

Viruses, 2012
In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens.
Kristina Brauburger, Adam J. Hume, Judith Olejnik, Elke Mühlberger   +3 more
doaj   +1 more source

Mathematical Modeling of Pulse‐Seeded Metapopulation Dynamics for Andes Hantavirus Border Dispersal

Engineering Reports, Volume 8, Issue 9, September 2026.
A pulse‐seeded metapopulation SEIR model for Andes hantavirus maritime dispersal shows that heterogeneous quarantine compliance determines secondary outbreak risk. The weakest‐compliance country governs global containment, while uniform compliance above ∼65%$$ \sim 65\% $$ reduces the global reproduction number below unity.
Gideon K. Gogovi, Paul Chataa
wiley   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, Volume 3, Issue 3, September 2026.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Tuning the Length of Filomicelles Prepared Via Templated Polymerization‐Induced Self‐Assembly

Small, Volume 22, Issue 51, 11 September 2026.
High‐aspect‐ratio polymeric micelles are attractive yet notoriously difficult to control in length. We reveal a counterintuitive and powerful solution: in supramolecularly templated PISA, adding non‐sticker polymer unexpectedly elongates the micelles, while post‐assembly sonication enables precise shortening with reduced dispersity.
Eleonora G. Hochreiner, Wiktoria Pioruńska, Gaëlle Mellot, Bence Fehér, Jean‐Michel Guigner, Viktoriia Drebezghova, Christophe Sinturel, Cornelus F. van Nostrum, Tina Vermonden, Jutta Rieger, Bas G. P. van Ravensteijn   +10 more
wiley   +1 more source

Suspected Exposure to Filoviruses Among People Contacting Wildlife in Southwestern Uganda [PDF]

, 2018
Background Human and filovirus host interactions remain poorly understood in areas where Ebola hemorrhagic fever outbreaks are likely to occur.
Emmanuel Mugisha, Christine K Johnson, Benard Ssebide, Peter A Barry, Scott Kellermann, Obed Mugisha, Johnson, Christine K, Eberhardt, Meghan, Michael R Cranfield, Kirsten V Gilardi, Barry, Peter A, Leonard Tutaryebwa, Marzi, Andrea, Tierra Smiley Evans, Mugisha, Emmanuel, Smiley Evans, Tierra, Andrea Marzi, Mugisha, Obed, Mazet, Jonna AK, Meghan Eberhardt, Jonna A K Mazet, Tutaryebwa, Leonard, Gilardi, Kirsten V, Kellermann, Scott, Ssebide, Benard, Cranfield, Michael R   +25 more
core   +1 more source

Fixing Epidemic Risk, Fixing Epidemic Spacetime? How Emerging Disease Science Writes Wild Stories About Pandemic Origins

Antipode, Volume 58, Issue 5, September 2026.
ABSTRACT Using the US Agency for International Development (USAID) PREDICT program as a case study, I argue that mainstream emerging disease science (re)produces Orientalist imaginaries of pandemic risk through narratives about wildlife infections as inherently “backwards” in epidemic time relative to human and domestic animal infections. This temporal
Mollie Holmberg
wiley   +1 more source

Development and Structural Analysis of Antibody Therapeutics for Filoviruses

, 2022
The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery ...
Xiaoying Yu, Erica Ollmann Saphire
core   +1 more source