Results 21 to 30 of about 5,390 (165)

Intracellular Events and Cell Fate in Filovirus Infection

Viruses, 2011
Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic cells. The infection spreads to the liver, spleen and later other organs by blood
Elena Ryabchikova, Ronald B. Corley, Elke Mühlberger, Judith Olejnik   +3 more
doaj   +1 more source

AAV Vectored Immunoprophylaxis for Filovirus Infections

Tropical Medicine and Infectious Disease, 2020
Filoviruses are among the deadliest infectious agents known to man, causing severe hemorrhagic fever, with up to 90% fatality rates. The 2014 Ebola outbreak in West Africa resulted in over 28,000 infections, demonstrating the large-scale human health and
Amira D. Rghei, Laura P. van Lieshout, Lisa A. Santry, Matthew M. Guilleman, Sylvia P. Thomas, Leonardo Susta, Khalil Karimi, Byram W. Bridle, Sarah K. Wootton   +8 more
doaj   +1 more source

Serologic Evidence of Fruit Bat Exposure to Filoviruses, Singapore, 2011–2016

Emerging Infectious Diseases, 2018
To determine whether fruit bats in Singapore have been exposed to filoviruses, we screened 409 serum samples from bats of 3 species by using a multiplex assay that detects antibodies against filoviruses.
Eric D. Laing, Ian H. Mendenhall, Martin Linster, Dolyce H. W. Low, Yihui Chen, Lianying Yan, Spencer L. Sterling, Sophie Borthwick, Erica Sena Neves, Julia S. L. Lim, Maggie Skiles, Benjamin P. Y.-H. Lee, Lin-Fa Wang, Christopher C. Broder, Gavin J. D. Smith   +14 more
doaj   +1 more source

Filoviruses are ancient and integrated into mammalian genomes

BMC Evolutionary Biology, 2010
Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy, Leach Robert W, Taylor Derek J   +2 more
doaj   +1 more source

γδ T Cells in Emerging Viral Infection: An Overview

Viruses, 2022
New emerging viruses belonging to the Coronaviridae, Flaviviridae, and Filoviridae families are serious threats to public health and represent a global concern.
Eleonora Cimini, Chiara Agrati
doaj   +1 more source

Detection of Filoviruses in Bats in Vietnam

Viruses, 2023
A new filovirus named Měnglà virus was found in bats in southern China in 2015. This species has been assigned to the new genus Dianlovirus and has only been detected in China. In this article, we report the detection of filoviruses in bats captured in Vietnam. We studied 248 bats of 15 species caught in the provinces of Lai Chau and Son La in northern
Marat T. Makenov, Lan Anh T. Le, Olga A. Stukolova, Ekaterina V. Radyuk, Evgeny S. Morozkin, Nga T. T. Bui, Olga B. Zhurenkova, Manh N. Dao, Chau V. Nguyen, Mo T. Luong, Dung T. Nguyen, Marina V. Fedorova, Anna V. Valdokhina, Victoria P. Bulanenko, Vasiliy G. Akimkin, Lyudmila S. Karan   +15 more
openaire   +3 more sources

Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover.

PLoS Neglected Tropical Diseases, 2019
Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission.
Pilot Dovih, Eric D Laing, Yihui Chen, Dolyce H W Low, B R Ansil, Xinglou Yang, Zhengli Shi, Christopher C Broder, Gavin J D Smith, Martin Linster, Uma Ramakrishnan, Ian H Mendenhall   +11 more
doaj   +1 more source

Filovirus Neutralising Antibodies: Mechanisms of Action and Therapeutic Application

Pathogens, 2021
Filoviruses, especially Ebola virus, cause sporadic outbreaks of viral haemorrhagic fever with very high case fatality rates in Africa. The 2013–2016 Ebola epidemic in West Africa provided large survivor cohorts spurring a large number of human studies ...
Alexander Hargreaves, Caolann Brady, Jack Mellors, Tom Tipton, Miles W. Carroll, Stephanie Longet   +5 more
doaj   +1 more source

Nonhuman Primates Are Protected against Marburg Virus Disease by Vaccination with a Vesicular Stomatitis Virus Vector-Based Vaccine Prepared under Conditions to Allow Advancement to Human Clinical Trials

Vaccines, 2022
Vaccines are needed to disrupt or prevent continued outbreaks of filoviruses in humans across Western and Central Africa, including outbreaks of Marburg virus (MARV). As part of a filovirus vaccine product development plan, it is important to investigate
Christopher L. Cooper, Gavin Morrow, Maoli Yuan, John W. Coleman, Fuxiang Hou, Lucia Reiserova, Shui L. Li, Denise Wagner, Alexei Carpov, Olivia Wallace-Selman, Kristie Valentin, Yesle Choi, Aaron Wilson, Andrew Kilianski, Eddy Sayeed, Krystle N. Agans, Viktoriya Borisevich, Robert W. Cross, Thomas W. Geisbert, Mark B. Feinberg, Swati B. Gupta, Christopher L. Parks   +21 more
doaj   +1 more source

Differentiation of filoviruses by electron microscopy [PDF]

Virus Research, 1995
Cultured monolayers of MA-104, Vero 76, SW-13, and DBS-FRhL-2 cells were infected with Marburg (MBG), Ebola-Sudan (EBO-S), Ebola-Zaire (EBO-Z), and Ebola-Reston (EBO-R) viruses (Filoviridae, Filovirus) and examined by electron microscopy to provide ultrastructural details of morphology and morphogenesis of these potential human pathogens.
Geisbert, T. W., Jahrling, P. B.
openaire   +3 more sources