Results 21 to 30 of about 5,548 (176)
Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan. [PDF]
Pharmacol Res PerspectABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Akinbolade S +5 more
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Assembly and transport of filovirus nucleocapsids
PLOS Pathogens, 2022 Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs) located in the perinuclear region. The formation of these IBs is induced mainly by the accumulation of the filoviral nucleoprotein NP, which recruits the other nucleocapsid proteins, the polymerase co-factor VP35, the polymerase L, the transcription factor VP30 and
Olga Dolnik, Stephan Becker
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A Call to Action to Enhance Filovirus Disease Outbreak Preparedness and Response
Viruses, 2014 The frequency and magnitude of recognized and declared filovirus-disease outbreaks have increased in recent years, while pathogenic filoviruses are potentially ubiquitous throughout sub-Saharan Africa.
Paul Roddy
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Clinical Management of Filovirus-Infected Patients
Viruses, 2012 Filovirus infection presents many unique challenges to patient management. Currently no approved treatments are available, and the recommendations for supportive care are not evidence based.
Danielle V. Clark +2 more
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Viruses, 2019 Macrophages are one of the first and also a major site of filovirus replication and, in addition, are a source of multiple cytokines, presumed to play a critical role in the pathogenesis of the viral infection. Some of these cytokines are known to induce
Tzanko S. Stantchev +5 more
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Filovirus assembly and budding
Virology, 2006 Filoviruses belong to the order of negative-stranded non-segmented RNA viruses and are classified into two genera, Ebola and Marburg viruses. They have a characteristic filamentous shape, which is largely determined by the matrix protein VP40. Although VP40 is the main driving force for assembly and budding from the host cell, the production of ...
Hartlieb, Bettina, Weissenhorn, Winfried
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Vaccines, 2020 In the infectious diseases field, protective immunity against individual virus species or strains does not always confer cross-reactive immunity to closely related viruses, leaving individuals susceptible to disease after exposure to related virus ...
Sarah Sebastian +11 more
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, 2013 A number of advances in recent years have significantly furthered our understanding of filovirus attachment and cellular tropism. For example, several cell-surface molecules have been identified as attachment factors with the potential to facilitate the in vivo targeting of particular cell types such as macrophages and hepatic cells.
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Filovirus Replication and Transcription [PDF]
Future Virology, 2007 The highly pathogenic filoviruses, Marburg and Ebola virus, belong to the nonsegmented negative-sense RNA viruses of the order Mononegavirales. The mode of replication and transcription is similar for these viruses. On one hand, the negative-sense RNA genome serves as a template for replication, to generate progeny genomes, and, on the other hand, for ...
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eLife, 2015 Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Melinda Ng +20 more
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