Results 21 to 30 of about 6,479 (200)

Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions

Viruses, 2012
Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics.
Suchita Bhattacharyya, Kartik Chandran, Nirupama Mulherkar   +2 more
doaj   +2 more sources

Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages

Viruses, 2019
Macrophages are one of the first and also a major site of filovirus replication and, in addition, are a source of multiple cytokines, presumed to play a critical role in the pathogenesis of the viral infection. Some of these cytokines are known to induce
Tzanko S. Stantchev, Autumn Zack-Taylor, Nicholas Mattson, Klaus Strebel, Christopher C. Broder, Kathleen A. Clouse   +5 more
doaj   +2 more sources

Ecologic and Geographic Distribution of Filovirus Disease [PDF]

Emerging Infectious Diseases, 2004
(Uploaded by Plazi for the Bat Literature Project) We used ecologic niche modeling of outbreaks and sporadic cases of filovirus-associated hemorrhagic fever (HF) to provide a large-scale perspective on the geographic and ecologic distributions of Ebola and Marburg viruses.
Peterson, A. Townsend, Bauer, John T., Mills, James N.   +2 more
openaire   +5 more sources

Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids. [PDF]

Mar Drugs
Filoviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Wang LL, Seravalli J, Eaton B, Liu Y, Holbrook MR, Lan WJ, Xiang SH.   +6 more
europepmc   +3 more sources

Filovirus tropism: Cellular molecules for viral entry

Frontiers in Microbiology, 2012
In human and nonhuman primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever．Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference
Ayato eTakada
doaj   +2 more sources

Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats

Viruses, 2023
Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse, Marinda Mortlock, Antoinette Grobbelaar, Naazneen Moolla, Wanda Markotter, Jacqueline Weyer   +5 more
doaj   +1 more source

Marburg and Sudan virus outbreaks: are we any closer to a pan-filovirus vaccine? [PDF]

Trop Dis Travel Med Vaccines
Filoviruses, including Ebola, Marburg, and Sudan viruses, cause severe hemorrhagic fevers with high mortality rates and outbreaks. While recent vaccine developments such as the rVSV-ZEBOV vaccine for Ebola have marked important progress and is now ...
Akingbola A, Adegbesan A, Adewole O, Olalude O, Isaiah O, Bhadmus F, Chuku J.   +6 more
europepmc   +2 more sources

Filovirus Infections in Travellers

Filovirus disease (FVD) outbreaks present significant public health challenges when they occur in West and Central Africa. FVD includes Ebola and Marburg disease that carry high case fatality rates and significant nosocomial risk, with limited proven ...
Fletcher, Tom
openaire   +2 more sources

Rational design of next-generation filovirus vaccines combining glycoprotein stabilization and nanoparticle display with glycan modification. [PDF]

Nat Commun
Filoviruses pose a significant threat to human health due to frequent outbreaks and high mortality. Although two vector-based vaccines are available for Ebola virus, a broadly protective filovirus vaccine remains elusive.
Lee YZ, Zhang YN, Newby ML, Ward G, Braz Gomes K, Auclair S, DesRoberts C, Allen JD, Ward AB, Stanfield RL, He L, Crispin M, Wilson IA, Zhu J.   +13 more
europepmc   +2 more sources

Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress. [PDF]

Viruses
Filoviruses, including Ebola (EBOV) and Marburg (MARV) viruses, are zoonotic pathogens that cause severe hemorrhagic fever in humans, with mortality rates reaching up to 90%.
Anand LK, Djurkovic MA, Shepley-McTaggart A, Shtanko O, Harty RN.   +4 more
europepmc   +2 more sources