Results 31 to 40 of about 6,479 (200)

A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates. [PDF]

PLoS ONE, 2018
The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections.
Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn   +20 more
doaj   +1 more source

Assembly and transport of filovirus nucleocapsids

PLOS Pathogens, 2022
Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs) located in the perinuclear region. The formation of these IBs is induced mainly by the accumulation of the filoviral nucleoprotein NP, which recruits the other nucleocapsid proteins, the polymerase co-factor VP35, the polymerase L, the transcription factor VP30 and
Olga Dolnik, Stephan Becker
openaire   +3 more sources

Identifying Suspect Bat Reservoirs of Emerging Infections

Vaccines, 2020
Bats host a number of pathogens that cause severe disease and onward transmission in humans and domestic animals. Some of these pathogens, including henipaviruses and filoviruses, are considered a concern for future pandemics.
Daniel Crowley, Daniel Becker, Alex Washburne, Raina Plowright   +3 more
doaj   +1 more source

Assays for the Evaluation of the Immune Response to Marburg and Ebola Sudan Vaccination—Filovirus Animal Nonclinical Group Anti-Marburg Virus Glycoprotein Immunoglobulin G Enzyme-Linked Immunosorbent Assay and a Pseudovirion Neutralization Assay

Vaccines, 2022
Since the discovery of the Marburg virus (MARV) in 1967 and Ebola virus (EBOV) in 1976, there have been over 40 reported outbreaks of filovirus disease with case fatality rates greater than 50%.
Thomas L. Rudge, Nicholas J. Machesky, Karen A. Sankovich, Erin E. Lemmon, Christopher S. Badorrek, Rachel Overman, Nancy A. Niemuth, Michael S. Anderson   +7 more
doaj   +1 more source

A high-throughput, polymerase-targeted RT-PCR for broad detection of mammalian filoviruses. [PDF]

Microbiol Spectr
Filoviruses are some of the most lethal viruses in the modern world, and increasing numbers of filovirus species and genera have been discovered in recent years.
Cui N, Perez YL, Hume AJ, Nunley BE, Kong K, Mills MG, Xie H, Greninger AL.   +7 more
europepmc   +2 more sources

Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses

Viruses, 2017
The mononegaviral family Filoviridae has eight members assigned to three genera and seven species. Until now, genus and species demarcation were based on arbitrarily chosen filovirus genome sequence divergence values (≈50% for genera, ≈30% for species ...
Yīmíng Bào, Gaya K. Amarasinghe, Christopher F. Basler, Sina Bavari, Alexander Bukreyev, Kartik Chandran, Olga Dolnik, John M. Dye, Hideki Ebihara, Pierre Formenty, Roger Hewson, Gary P. Kobinger, Eric M. Leroy, Elke Mühlberger, Sergey V. Netesov, Jean L. Patterson, Janusz T. Paweska, Sophie J. Smither, Ayato Takada, Jonathan S. Towner, Viktor E. Volchkov, Victoria Wahl-Jensen, Jens H. Kuhn   +22 more
doaj   +1 more source

Clinical documentation and data transfer from Ebola and Marburg virus disease wards in outbreak settings: health care workers' experiences and preferences. [PDF]

, 2014
Understanding human filovirus hemorrhagic fever (FHF) clinical manifestations and evaluating treatment strategies require the collection of clinical data in outbreak settings, where clinical documentation has been limited.
Roddy, Paul, Nolte, Ellen, Matthias Borchert, Ellen Nolte, Paul Roddy, Borchert, Matthias, Bühler, Silja, Silja Bühler   +7 more
core   +1 more source

Filoviruses are ancient and integrated into mammalian genomes

BMC Evolutionary Biology, 2010
Background Hemorrhagic diseases from Ebolavirus and Marburgvirus (Filoviridae) infections can be dangerous to humans because of high fatality rates and a lack of effective treatments or vaccine.
Bruenn Jeremy, Leach Robert W, Taylor Derek J   +2 more
doaj   +1 more source

Undiscovered Bat Hosts of Filoviruses.

PLoS Neglected Tropical Diseases, 2016
Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high ...
Barbara A Han, John Paul Schmidt, Laura W Alexander, Sarah E Bowden, David T S Hayman, John M Drake   +5 more
doaj   +1 more source

Challenges, Progress, and Opportunities: Proceedings of the Filovirus Medical Countermeasures Workshop

Viruses, 2014
On August 22–23, 2013, agencies within the United States Department of Defense (DoD) and the Department of Health and Human Services (HHS) sponsored the Filovirus Medical Countermeasures (MCMs) Workshop as an extension of the activities of the Filovirus ...
Rona Hirschberg, Lucy A. Ward, Nicole Kilgore, Rebecca Kurnat, Helen Schiltz, Mark T. Albrecht, George W. Christopher, Ed Nuzum   +7 more
doaj   +1 more source