Results 31 to 40 of about 7,064 (200)

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates. [PDF]

PLoS Neglected Tropical Diseases, 2012
The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (
Chad E Mire, Andrew D Miller, Angela Carville, Susan V Westmoreland, Joan B Geisbert, Keith G Mansfield, Heinz Feldmann, Lisa E Hensley, Thomas W Geisbert   +8 more
doaj   +1 more source

Cytokine Effects on the Entry of Filovirus Envelope Pseudotyped Virus-Like Particles into Primary Human Macrophages

Viruses, 2019
Macrophages are one of the first and also a major site of filovirus replication and, in addition, are a source of multiple cytokines, presumed to play a critical role in the pathogenesis of the viral infection. Some of these cytokines are known to induce
Tzanko S. Stantchev, Autumn Zack-Taylor, Nicholas Mattson, Klaus Strebel, Christopher C. Broder, Kathleen A. Clouse   +5 more
doaj   +1 more source

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity

Frontiers in Immunology, 2021
Multiple agents in the family Filoviridae (filoviruses) are associated with sporadic human outbreaks of highly lethal disease, while others, including several recently identified agents, possess strong zoonotic potential. Although viral glycoprotein (GP)-
Ariel S. Wirchnianski, Ariel S. Wirchnianski, Anna Z. Wec, Elisabeth K. Nyakatura, Andrew S. Herbert, Andrew S. Herbert, Megan M. Slough, Ana I. Kuehne, Eva Mittler, Rohit K. Jangra, Jonathan Teruya, John M. Dye, Jonathan R. Lai, Kartik Chandran   +13 more
doaj   +1 more source

Ad35 and ad26 vaccine vectors induce potent and cross-reactive antibody and T-cell responses to multiple filovirus species. [PDF]

PLoS ONE, 2012
Filoviruses cause sporadic but highly lethal outbreaks of hemorrhagic fever in Africa in the human population. Currently, no drug or vaccine is available for treatment or prevention.
Roland Zahn, Gert Gillisen, Anna Roos, Marina Koning, Esmeralda van der Helm, Dirk Spek, Mo Weijtens, Maria Grazia Pau, Katarina Radošević, Gerrit Jan Weverling, Jerome Custers, Jort Vellinga, Hanneke Schuitemaker, Jaap Goudsmit, Ariane Rodríguez   +14 more
doaj   +1 more source

Mouse Models for Filovirus Infections [PDF]

Viruses, 2012
The filoviruses marburg- and ebolaviruses can cause severe hemorrhagic fever (HF) in humans and nonhuman primates. Because many cases have occurred in geographical areas lacking a medical research infrastructure, most studies of the pathogenesis of filoviral HF, and all efforts to develop drugs and vaccines, have been carried out in biocontainment ...
Kelly L. Warfield, Steven B. Bradfute, Mike Bray   +2 more
openaire   +3 more sources

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

eLife, 2015
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Melinda Ng, Esther Ndungo, Maria E Kaczmarek, Andrew S Herbert, Tabea Binger, Ana I Kuehne, Rohit K Jangra, John A Hawkins, Robert J Gifford, Rohan Biswas, Ann Demogines, Rebekah M James, Meng Yu, Thijn R Brummelkamp, Christian Drosten, Lin-Fa Wang, Jens H Kuhn, Marcel A Müller, John M Dye, Sara L Sawyer, Kartik Chandran   +20 more
doaj   +1 more source

A Multi-Filovirus Vaccine Candidate: Co-Expression of Ebola, Sudan, and Marburg Antigens in a Single Vector

Vaccines, 2020
In the infectious diseases field, protective immunity against individual virus species or strains does not always confer cross-reactive immunity to closely related viruses, leaving individuals susceptible to disease after exposure to related virus ...
Sarah Sebastian, Amy Flaxman, Kuan M. Cha, Marta Ulaszewska, Ciaran Gilbride, Hannah Sharpe, Edward Wright, Alexandra J. Spencer, Stuart Dowall, Roger Hewson, Sarah Gilbert, Teresa Lambe   +11 more
doaj   +1 more source

Filovirus assembly and budding

Virology, 2006
Filoviruses belong to the order of negative-stranded non-segmented RNA viruses and are classified into two genera, Ebola and Marburg viruses. They have a characteristic filamentous shape, which is largely determined by the matrix protein VP40. Although VP40 is the main driving force for assembly and budding from the host cell, the production of ...
Hartlieb, Bettina, Weissenhorn, Winfried
openaire   +2 more sources

Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor

Viruses, 2012
We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Esther Ndungo, John M. Dye, Sean P. Whelan, Melinda Ng, Andrew S. Herbert, Anuja Krishnan, Emily Happy Miller, Kartik Chandran   +7 more
doaj   +1 more source

Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover - Fig 2

, 2019
MFI values for sera obtained from humans (A), Eonycteris spelaea (B), Rousettus leschenaultii (C). Antibodies reactive to filovirus GPe from Ebola virus (EBOV), Bundibugyo virus (BDBV), Taï Forest virus (TAFV), Sudan ebolavirus (SUDV), Reston virus ...
B. R. Ansil (7609943), Uma Ramakrishnan (4564), Eric D. Laing (7609940), Yihui Chen (446576), Christopher C. Broder (7609946), Ian H. Mendenhall (7470851), Zhengli Shi (203756), Gavin J. D. Smith (6872954), Pilot Dovih (7609937), Xinglou Yang (6368906), Dolyce H. W. Low (4172911), Martin Linster (343086)   +11 more
core   +1 more source