Results 51 to 60 of about 6,479 (200)

Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover

, 2019
Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia. High risk activities at the bat-human interface pose the threat of zoonotic virus transmission.
B. R. Ansil (7609943), Ansil, B. R., Yihui Chen (446576), Pilot Dovih (7609937), Xinglou Yang (6368906), Dolyce H. W. Low (4172911), Mendenhall, I.H., Mendenhall, Ian H., Yang, X., Broder, Christopher C., Eric D. Laing (7609940), Low, D.H.W., Chen, Yihui, Laing, Eric D., Martin Linster (343086), Dovih, Pilot, Mossel, Eric, Smith, G.J.D., Ramakrishnan, U., Christopher C. Broder (7609946), Ian H. Mendenhall (7470851), Ramakrishnan, Uma, Gavin J. D. Smith (6872954), Chen, Y., Shi, Z., Linster, M., Uma Ramakrishnan (4564), Broder, C.C., Laing, E.D., Shi, Zhengli, Ansil, B.R., Zhengli Shi (203756), Yang, Xinglou, Dovih, P., Linster, Martin, Low, Dolyce H. W., Smith, Gavin J. D.   +36 more
core   +1 more source

Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors

Cell Reports, 2018
Summary: Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can protect against infection. It is currently unknown whether natural infection also induces some antibodies with the capacity for antibody-dependent enhancement
Natalia A. Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo I. Santos, Andrew I. Flyak, Philipp A. Ilinykh, Kai Huang, Ndongala M. Lubaki, Palaniappan Ramanathan, James E. Crowe, Jr., Alexander Bukreyev   +10 more
doaj   +1 more source

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates.

PLoS ONE, 2014
The filoviruses, Marburg virus (MARV) and Ebola virus, causes severe hemorrhagic fever with high mortality in humans and nonhuman primates. A promising filovirus vaccine under development is based on a recombinant vesicular stomatitis virus (rVSV) that ...
Chad E Mire, Joan B Geisbert, Krystle N Agans, Benjamin A Satterfield, Krista M Versteeg, Elizabeth A Fritz, Heinz Feldmann, Lisa E Hensley, Thomas W Geisbert   +8 more
doaj   +1 more source

Viewpoint: filovirus haemorrhagic fever outbreaks: much ado about nothing?

, 2000
The recent outbreak of Marburg haemorrhagic fever in the Democratic Republic of Congo has put the filovirus threat back on the international health agenda.
Boelaert, M, Van der Stuyft, P, J. J. Muyembe-tamfum, van der Groen, G, Muyembe-Tamfum, JJ, Muyembe-Tamfum, J. J., M. Borchert, Sleurs, H, P. Van Der Stuyft, Van Der Stuyft, Patrick, Boelaert, M., P. Pirard, Pirard, P, Colebunders, R., M. Boelaert, Borchert, M., Van der Stuyft, P., H. Sleurs, Borchert, M, Pirard, P., Sleurs, H., R. Colebunders, van der Groen, G., Colebunders, R, Muyembe-Tamfum, J J   +24 more
core   +1 more source

Risk factors for Marburg hemorrhagic fever, Democratic Republic of the Congo. [PDF]

, 2003
We conducted two antibody surveys to assess risk factors for Marburg hemorrhagic fever in an area of confirmed Marburg virus transmission in the Democratic Republic of the Congo.
Roth, Cathy, Ksiazek, T. G., Grein, Thomas, Bausch, Daniel G, Kond\ue9, Kader M., Ben Tugume, Modeste L. Libande, Pirard, Patricia, Pierre E. Rollin, Tugume, B., Colebunders, Robert, Bausch, Daniel G., Muyembe-Tamfum, Jean-Jacques, Olinda, L. L., Rodier, G. R., Matthias Borchert, Kondé, Kader M, Talarmin, A., Ksiazek, Thomas G, Borchert, M., Rollin, P. E., Daniel G. Bausch, Pirard, P., Bausch, D. G., Rollin, Pierre E, Thomas G. Ksiazek, Rodier, Guénaël R, Swanepoel, R., Ksiazek, Thomas G., Swanepoel, Robert, Kader M. Kondé, Campbell, P., Campbell, Patricia, Thomas Grein, Libande, Modeste L, Grein, T., Muyembe-Tamfum, J. J., Robert Colebunders, Robert Swanepoel, Jean-Jacques Muyembe-Tamfum, Patricia Pirard, Oyewale Tomori, Patricia Campbell, Tomori, Oyewale, Cathy Roth, Loku L. Olinda, Tugume, Ben, Colebunders, R., Talarmin, Antoine, Roth, C., Libande, M. L., Bertherat, E., Libande, Modeste L., Guénaël R. Rodier, Pirad, Patricia, Olinda, Loku L., Antoine Talarmin, Kondé, K. M., Rollin, Pierre E., Eric Bertherat, Tomori, O., Borchert, Matthias, Bertherat, Eric, Olinda, Loku L, Rodier, Gu\ue9na\uebl R.   +64 more
core   +1 more source

AAV Vectored Immunoprophylaxis for Filovirus Infections [PDF]

Tropical Medicine and Infectious Disease, 2020
Filoviruses are among the deadliest infectious agents known to man, causing severe hemorrhagic fever, with up to 90% fatality rates. The 2014 Ebola outbreak in West Africa resulted in over 28,000 infections, demonstrating the large-scale human health and economic impact generated by filoviruses.
Amira D. Rghei, Laura P. van Lieshout, Lisa A. Santry, Matthew M. Guilleman, Sylvia P. Thomas, Leonardo Susta, Khalil Karimi, Byram W. Bridle, Sarah K. Wootton   +8 more
openaire   +3 more sources

Filovirus Hemorrhagic Fever Outbreak Case Management: A Review of Current and Future Treatment Options

, 2011
: Testing an innovative therapy for filovirus hemorrhagic fever (FHF) in an outbreak setting may be years away. Moreover, beyond anecdotal evidence, little is known about best practice for outbreak case management.
Borchert, M., Roddy, Paul, Jeffs, B., Robert Colebunders, Benjamin Jeffs, van Herp, Michel, Van Herp, M., Pedro Pablo Palma, Roddy, P., Jeffs, Benjamin, Colebunders, Robert, Matthias Borchert, Paul Roddy, Palma, P. P., Borchert, Matthias, Colebunders, R., Michel Van Herp, Palma, Pedro Pablo   +17 more
core   +1 more source

Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease

BMC Infectious Diseases, 2018
Background Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and international spread.
Peace Babirye, Carol Musubika, Samuel Kirimunda, Robert Downing, Julian J Lutwama, Edward K Mbidde, Jacqueline Weyer, Janusz T Paweska, Moses L Joloba, Misaki Wayengera   +9 more
doaj   +1 more source

Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing. [PDF]

PLoS ONE, 2014
A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus allowing for appropriate therapeutic and containment procedures.
Jeffrey W Koehler, Adrienne T Hall, P Alexander Rolfe, Anna N Honko, Gustavo F Palacios, Joseph N Fair, Jean-Jacques Muyembe, Prime Mulembekani, Randal J Schoepp, Adeyemi Adesokan, Timothy D Minogue   +10 more
doaj   +1 more source

Possible leap ahead in filovirus therapeutics [PDF]

Cell Research, 2014
In a recent study published in Nature, Warren et al. describe the generation of a novel synthetic adenosine analogue, BCX4430, a synthetic drug-like small molecule that provides protection from Ebola and Marburg virus infection in animal models.
Darryl, Falzarano, Heinz, Feldmann
openaire   +2 more sources