Results 71 to 80 of about 7,064 (200)

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids

Marine Drugs
Filoviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang, Javier Seravalli, Brett Eaton, Yi Liu, Michael R. Holbrook, Wen-Jian Lan, Shi-Hua Xiang   +6 more
doaj   +1 more source

Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley   +1 more source

Rapid molecular strategy for filovirus detection and characterization [PDF]

, 2007
Filoviruses have the capacity to cause lethal outbreaks of hemorrhagic fever in primates. Here we present a simple consensus reverse transcription-PCR method for filovirus recognition and characterization and demonstrate its utility with all known ...
Nichol, Stuart T., Feldmann, Heinz, Grolla, Allen, Zhai, Junhui, Briese, Thomas, Paweska, Janusz Tadeusz, Towner, Jonathan S., Kapoor, Vishal, Lipkin, Ian W., Jabado, Omar, Venter, Marietjie, Palacios, Gustavo, Swanepoel, Robert   +12 more
core   +1 more source

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

mBio, 2016
The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immune ...
Zachary A. Bornholdt, Esther Ndungo, Marnie L. Fusco, Shridhar Bale, Andrew I. Flyak, James E. Crowe, Kartik Chandran, Erica Ollmann Saphire   +7 more
doaj   +1 more source

Detection of filovirus-reactive antibodies in Australian bat species [PDF]

, 2022
Bats have been implicated as the reservoir hosts of filoviruses in Africa, with serological evidence of filoviruses in various bat species identified in other countries.
Adams, T.E., Pearce, L., Vanderduys, E., Smith, I., Marsh, G.A., O'Dea, M., McKeown, A., Baker, M.L., Jackson, B., Prada, D., Westcott, D., Boyd, V., Barr, J., Todd, S.   +13 more
core  

New filovirus disease classification and nomenclature [PDF]

Nature Reviews Microbiology, 2019
(Uploaded by Plazi for the Bat Literature Project) No abstract provided.
Kuhn, Jens H., Adachi, Takuya, Adhikari, Neill K.J., Arribas, Jose R., Bah, Ibrahima E., Bausch, Daniel G., Bhadelia, Nahid, Borchert, Matthias, Brantsæter, Arne Broch, Brett-Major, David M., Burgess, Timothy H., Castro-Ria, Lado Marta, Chertow, Daniel S., Chute, Christopher G., Cieslak, Theodore J., Colebunders, Robert, Crozier, Ian, Davey, Richard T., De Clerck, Hilde, Delgado, Rafael, Evans, Laura, Fallah, Mosoka, Fischer, William A., II, Fischer, Fletcher, Tom E., Fowler, Robert A., Grunewald, Thomas, Hall, Andy, Hewlett, Angela, Hoepelman, Andy I.M., Houlihan. Catherine F., Ippolito, Giuseppe, Jacob, Shevin T., Jacobs, Michael, Jakob, Robert, Jacquerioz, Frederique A., Kaiser, Laurent, Kalil, Andre C., Kamara, Rashidatu F., Kapetshi, Jimmy, Klenk, Hans-Dieter, Kobinger, Gary, Kortepeter, Mark G., Kraft, Colleen S., Kratz, Thomas, Bosa, Henry S. Kyobe, Lamontagne, Francois, Lane, H. Cliff, Lobel, Leslie, Lutwama, Julius, III, G. Marshall Lyon, Massaquoi, Moses B.F., Massaquoi, Thomas A., Mehta, Aneesh K., Makuma, Vital Mondonge, Murthy, Srinivas, Musoke, Tonny Seikikongo, Muyembe-Tamfum, Jean-Jacques, Nakyeyune, Phiona, Nanclares, Carolina, Nanyunja, Miriam, Nsio-Mbeta, Justus, O’Dempsey, Tim, Pawęska, Janusz T., Peters, Clarence J., Piot, Peter, Rapp, Christophe, Renaud, Bertrand, Ribner, Bruce, Sabeti, Pardis C., Schieffelin, John S., Slenczka, Werner, Soka, Moses J., Sprecher, Armand, Strong, James, Swanepoel, Robert, Uyeki, Timothy M., Van Herp, Michel, Vetter, Pauline, Wohl, David A., Wolf, Timo, Wolz, Anja, Wurie, Alie H., Yoti, Zabulon   +83 more
openaire   +9 more sources

Filoviruses: One of These Things is (not) Like the Other

Viruses, 2015
The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus
Scott M. Anthony, Steven B. Bradfute
doaj   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, Volume 39, Issue 3, Page 346-367, April 2026.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source