Results 71 to 80 of about 5,548 (176)

Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir

Viruses, 2019
The 2014 Ebolavirus outbreak in West Africa highlighted the need for vaccines and therapeutics to prevent and treat filovirus infections. A well-characterized small animal model that is susceptible to wild-type filoviruses would facilitate the screening ...
Jason E. Comer, Olivier Escaffre, Natasha Neef, Trevor Brasel, Terry L. Juelich, Jennifer K. Smith, Jeanon Smith, Birte Kalveram, David D. Perez, Shane Massey, Lihong Zhang, Alexander N. Freiberg   +11 more
doaj   +1 more source

Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.

PLoS Pathogens, 2019
There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen.
Md Niaz Rahim, Edmund G Wee, Shihua He, Jonathan Audet, Kevin Tierney, Nathifa Moyo, Zara Hannoun, Alison Crook, Andrea Baines, Bette Korber, Xiangguo Qiu, Tomáš Hanke   +11 more
doaj   +1 more source

Discovery of an Ebolavirus-Like Filovirus in Europe

PLoS Pathogens, 2011
(Uploaded by Plazi for the Bat Literature Project) Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease.
Negredo, Ana, Palacios, Gustavo, Vázquez-Morón, Sonia, González, Félix, Dopazo, Hernán, Molero, Francisca, Juste, Javier, Quetglas, Juan, Savji, Nazir, De La Cruz Martínez, Maria, Herrera, Jesus Enrique, Pizarro, Manuel, Hutchison, Stephen K., Echevarría, Juan E., Lipkin, W. Ian, Tenorio, Antonio, Basler, Christopher F.   +16 more
openaire   +9 more sources

Filovirus tropism: Cellular molecules for viral entry

Frontiers in Microbiology, 2012
In human and nonhuman primates, filoviruses (Ebola and Marburg viruses) cause severe hemorrhagic fever．Recently, other animals such as pigs and some species of fruit bats have also been shown to be susceptible to these viruses. While having a preference
Ayato eTakada
doaj   +1 more source

Evasion of the Interferon-Mediated Antiviral Response by Filoviruses

Viruses, 2010
The members of the filoviruses are recognized as some of the most lethal viruses affecting human and non-human primates. The only two genera of the Filoviridae family, Marburg virus (MARV) and Ebola virus (EBOV), comprise the main etiologic agents of ...
Washington B. Cárdenas
doaj   +1 more source

Evolutionary maintenance of filovirus-like genes in bat genomes

BMC Evolutionary Biology, 2011
Background Little is known of the biological significance and evolutionary maintenance of integrated non-retroviral RNA virus genes in eukaryotic host genomes.
Taylor Derek J, Dittmar Katharina, Ballinger Matthew J, Bruenn Jeremy A   +3 more
doaj   +1 more source

Filovirus infections: science and innovation

Сибирский научный медицинский журнал
Epidemics of Filovirus Hemorrhagic Fevers demonstrate an increase in incidence, a reduction in the intervals between outbreaks, the emergence of a risk of infection spreading to non-endemic regions in recent years.
L. N. Aftaeva, V. L. Melnikov, A. V. Arekhina   +2 more
doaj   +1 more source

Peripheral immune responses to filoviruses in a reservoir versus spillover hosts reveal transcriptional correlates of disease

Frontiers in Immunology
Several filoviruses, including Marburg virus (MARV), cause severe disease in humans and nonhuman primates (NHPs). However, the Egyptian rousette bat (ERB, Rousettus aegyptiacus), the only known MARV reservoir, shows no overt illness upon natural or ...
Jonathan C. Guito, Catherine E. Arnold, Catherine E. Arnold, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Jessica R. Spengler, Jessica R. Harmon, Joann D. Coleman-McCray, Mariano Sanchez-Lockhart, Gustavo F. Palacios, Jonathan S. Towner, Joseph B. Prescott, Joseph B. Prescott   +13 more
doaj   +1 more source

Doença Causada por Filovírus: Uma Atualização

Acta Médica Portuguesa
Os vírus Marburgo e Ébola pertencem à família Filoviridae e são conhecidos por causar doenças zoonóticas emergentes. Estes vírus apresentam alta letalidade e são facilmente transmissíveis de pessoa para pessoa, o que os torna potencialmente capazes de ...
Rafael Marx de Andrade, Andreia Paulos, Emília Valadas, Vitor Laerte Pinto Junior   +3 more
doaj   +1 more source

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

eLife
Marburg virus (MARV) is one of the filovirus species that cause deadly hemorrhagic fever in humans, with mortality rates up to 90%. Neutralizing antibodies represent ideal candidates to prevent or treat virus disease.
Yuting Zhang, Min Zhang, Haiyan Wu, Xinwei Wang, Hang Zheng, Junjuan Feng, Jing Wang, Longlong Luo, He Xiao, Chunxia Qiao, Xinying Li, Yuanqiang Zheng, Weijin Huang, Youchun Wang, Yi Wang, Yanchun Shi, Jiannan Feng, Guojiang Chen   +17 more
doaj   +1 more source