Results 81 to 90 of about 6,479 (200)
Positive Selection Drives Evolution at the Host-Filovirus Interaction Surface
, 2016 Filovirus infection is mediated by engagement of the surface-exposed glycoprotein (GP) by its cellular receptor, NPC1 (Niemann-Pick C1). Two loops in the C domain of NPC1 (NPC1-C) bind filovirus GP.
M. Clerici +7 more
core +1 more source
Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology
Annals of the New York Academy of Sciences, Volume 1550, Issue 1, Page 151-172, August 2025.Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker +11 more
wiley +1 more source
Discovery of an Ebolavirus-Like Filovirus in Europe
PLoS Pathogens, 2011 (Uploaded by Plazi for the Bat Literature Project) Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease.
Negredo, Ana +16 more
openaire +10 more sources
Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus
The FASEB Journal, Volume 39, Issue 14, 31 July 2025.RSV spreads through three main modes of infection: receptor‐dependent infection of free viral particles, syncytia formation, and transmission via actin filaments. CX3CR1, CCR3, and HSPG mediate viral adsorption; the IGF1R signaling pathway facilitates viral internalization by recruiting NCL to the membrane surface, and the RHO GTPase and PI3K signaling
Han Zhang +3 more
wiley +1 more source
From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis
Microbial Biotechnology, Volume 18, Issue 7, July 2025.Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley +1 more source
PLoS Neglected Tropical Diseases, 2016 BackgroundThe 2013-15 Ebola outbreak was unprecedented due to sustained transmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance about
Julii Brainard +4 more
doaj +1 more source
Filoviruses: One of These Things is (not) Like the Other
Viruses, 2015 The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus
Scott M. Anthony, Steven B. Bradfute
doaj +1 more source
PLoS Pathogens, 2019 There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen.
Md Niaz Rahim +11 more
doaj +1 more source
Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir
Viruses, 2019 The 2014 Ebolavirus outbreak in West Africa highlighted the need for vaccines and therapeutics to prevent and treat filovirus infections. A well-characterized small animal model that is susceptible to wild-type filoviruses would facilitate the screening ...
Jason E. Comer +11 more
doaj +1 more source
Investigating Filovirus Expression in Monodelphis domestica
, 2015 In this study, we explored the expression of a filovirus nucleoprotein (NP) gene and a filovirus RNA dependent RNA polymerase (L) gene in Monodelphis domestica. While we know that these filovirus genes are maintained within M.
Stuff, Daniel
core