Results 61 to 70 of about 6,479 (200)
Rapid molecular strategy for filovirus detection and characterization [PDF]
, 2007 Filoviruses have the capacity to cause lethal outbreaks of hemorrhagic fever in primates. Here we present a simple consensus reverse transcription-PCR method for filovirus recognition and characterization and demonstrate its utility with all known ...
Nichol, Stuart T. +12 more
core +1 more source
Viruses, 2019 Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of ...
Francisco J. Zapatero-Belinchón +17 more
doaj +1 more source
Cellular Factors Implicated in Filovirus Entry [PDF]
Advances in Virology, 2013 Although filoviral infections are still occurring in different parts of the world, there are no effective preventive or treatment strategies currently available against them. Not only do filoviruses cause a deadly infection, but they also have the potential of being used as biological weapons.
Suchita Bhattacharyya, Thomas J. Hope
openaire +3 more sources
Interaction of filovirus proteins with RIG-I signaling pathways [PDF]
, 2022 Filovirus family consist of highly pathogenic negative-strand RNA viruses that are characterized by their filamentous virion structure. The main focus in previous research has been on ebolaviruses and marburgviruses due to the large epidemics caused by ...
He, Felix
core
Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
Cell Reports, 2020 Summary: Fruit bats are suspected to be natural hosts of filoviruses, including Ebola virus (EBOV) and Marburg virus (MARV). Interestingly, however, previous studies suggest that these viruses have different tropisms depending on the bat species.
Yoshihiro Takadate +15 more
doaj +1 more source
Frontiers in Immunology, 2022 Filovirus family consists of highly pathogenic viruses that have caused fatal outbreaks especially in many African countries. Previously, research focus has been on Ebola, Sudan and Marburg viruses leaving other filoviruses less well studied. Filoviruses,
Felix B. He +10 more
doaj +1 more source
New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs. [PDF]
Front ChemEbola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective ...
Tamilarasi W, Balamurugan BJ.
europepmc +2 more sources
A new player in the puzzle of filovirus entry [PDF]
Nature Reviews Microbiology, 2012 Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore,
Judith M, White, Kathryn L, Schornberg
openaire +2 more sources
Electron tomography reveals the steps in filovirus budding.
, 2010 The filoviruses, Marburg and Ebola, are non-segmented negative-strand RNA viruses causing severe hemorrhagic fever with high mortality rates in humans and nonhuman primates.
Welsch, Sonja +17 more
core +1 more source
Animal models for filovirus infections.
Zoological research, 2018 The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of ...
Siragam, Vinayakumar +2 more
openaire +2 more sources