Results 61 to 70 of about 5,548 (176)

In Silico Identification of Antiviral Peptides as Potential Leads Against Sudan Ebolavirus VP‐40

BioMed Research International, Volume 2026, Issue 1, 2026.
The continued reemergence of Ebola virus epidemics remains a global health concern, largely due to limited therapeutic interventions. This study is aimed at identifying and characterizing antiviral peptides as potential lead candidates against the Sudan Ebola virus.
Boniface Omara, Kenedy Kiyimba, Fatoumata G. Fofana, Oudou Diabaté, Walter Odur, Daudi Jjingo, Jacob Stanley Iramiot, Peace Draleru, Joan Achia, Muhammad Shafiq, Zaheer Ul-Haq, Hedmon Okella, Steven Odongo, Swaran J. S. Flora   +13 more
wiley   +1 more source

Cutaneous manifestations of filovirus infections

International Journal of Dermatology, 2012
AbstractEbolavirus and Marburgvirus, two filoviruses belonging to the Filoviridae family, are among the most virulent pathogens for humans and non‐human primates, causing outbreaks of fulminant hemorrhagic fever (HF) in Central African countries with case fatality rates of up to 90%.
Nkoghe, D., /Leroy, Eric, Toung-Mve, M., /Gonzalez, Jean-Paul   +3 more
openaire   +4 more sources

Integrating Optimal Control and Economic Analysis to Inform Marburg Virus Response: A Comparison of Intervention Packages

Journal of Mathematics, Volume 2026, Issue 1, 2026.
Marburg virus disease is a severe hemorrhagic illness caused by filoviruses that kills roughly half of those it infects, yet no licensed vaccine or specific antiviral treatment currently exists. When an outbreak strikes a resource‐poor region, health officials face an agonizing question: which interventions offer the most protection for the least cost?
Raed Qahiti, Gizachew Kefelew Hailu, Ali H. Hakami, Ahmad Albaity, Shewafera Wondimagegnhu Teklu, Smritijit Sen   +5 more
wiley   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source

FILOVIRUS TRANSCRIPTION AND REPLICATION [PDF]

, 2014
Filoviruses belong to the group of nonsegmented, negative-sense (NNS) RNA viruses and are members of the order Mononegavirales along with the rhabdo-, paramyxo-, nyami-, and bornaviruses. Mononegaviruses share a general mechanism to replicate and transcribe their genomes, reflected in functionally homologous proteins and a similar genome structure ...
Kristina Brauburger, Laure R. Deflubé, Elke Mühlberger   +2 more
openaire   +1 more source

Filoviruses: One of These Things is (not) Like the Other

Viruses, 2015
The family Filoviridae contains several of the most deadly pathogens known to date and the current Ebola virus disease (EVD) outbreak in Western Africa, due to Ebola virus (EBOV) infection, highlights the need for active and broad research into filovirus
Scott M. Anthony, Steven B. Bradfute
doaj   +1 more source

Production of human cathepsins using Expi293™ mammalian cell expression system for off‐target activity of cysteine protease inhibitor screening

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of antivirals targeting cysteine proteases will emerge.
Zoe Turner, Elena Arutyunova, Duong T. Bui, Ling Han, Appan Srinivas Kandadai, Bing Bai, Howard S. Young, Lara K. Mahal, John S. Klassen, M. Joanne Lemieux   +9 more
wiley   +1 more source

Presence and Persistence of Ebola or Marburg Virus in Patients and Survivors: A Rapid Systematic Review.

PLoS Neglected Tropical Diseases, 2016
BackgroundThe 2013-15 Ebola outbreak was unprecedented due to sustained transmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance about
Julii Brainard, Katherine Pond, Lee Hooper, Kelly Edmunds, Paul Hunter   +4 more
doaj   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, Volume 58, Issue 11, November 2025.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Animal models for filovirus infections.

Zoological research, 2018
The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of ...
Siragam, Vinayakumar, Wong, Gary, Qiu, Xiang-Guo   +2 more
openaire   +2 more sources