Results 41 to 50 of about 9,268 (209)

A Multi-Filovirus Vaccine Candidate: Co-Expression of Ebola, Sudan, and Marburg Antigens in a Single Vector

Vaccines, 2020
In the infectious diseases field, protective immunity against individual virus species or strains does not always confer cross-reactive immunity to closely related viruses, leaving individuals susceptible to disease after exposure to related virus ...
Sarah Sebastian, Amy Flaxman, Kuan M. Cha, Marta Ulaszewska, Ciaran Gilbride, Hannah Sharpe, Edward Wright, Alexandra J. Spencer, Stuart Dowall, Roger Hewson, Sarah Gilbert, Teresa Lambe   +11 more
doaj   +1 more source

Ad35 and ad26 vaccine vectors induce potent and cross-reactive antibody and T-cell responses to multiple filovirus species. [PDF]

PLoS ONE, 2012
Filoviruses cause sporadic but highly lethal outbreaks of hemorrhagic fever in Africa in the human population. Currently, no drug or vaccine is available for treatment or prevention.
Roland Zahn, Gert Gillisen, Anna Roos, Marina Koning, Esmeralda van der Helm, Dirk Spek, Mo Weijtens, Maria Grazia Pau, Katarina Radošević, Gerrit Jan Weverling, Jerome Custers, Jort Vellinga, Hanneke Schuitemaker, Jaap Goudsmit, Ariane Rodríguez   +14 more
doaj   +1 more source

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]

, 2017
Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K, Basler, Christopher F, Batra, Jyoti, Leung, Daisy W, Luthra, Priya, Wu, Chao, Xu, Wei   +6 more
core   +2 more sources

Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions

Viruses, 2012
Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics.
Suchita Bhattacharyya, Kartik Chandran, Nirupama Mulherkar   +2 more
doaj   +1 more source

A retrospective cohort investigation of seroprevalence of Marburg virus and ebolaviruses in two different ecological zones in Uganda

BMC Infectious Diseases, 2020
Background Uganda has experienced seven Ebola Virus Disease (EVD) outbreaks and four Marburg Virus Disease (MVD) outbreaks between 2000 and 2019. We investigated the seroprevalence and risk factors for Marburg virus and ebolaviruses in gold mining ...
Luke Nyakarahuka, Ilana J. Schafer, Stephen Balinandi, Sophia Mulei, Alex Tumusiime, Jackson Kyondo, Barbara Knust, Julius Lutwama, Pierre Rollin, Stuart Nichol, Trevor Shoemaker   +10 more
doaj   +1 more source

Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. [PDF]

, 2020
Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus ...
Amara, Emmanuel, Amman, Brian R, Bairoh, Fatmata V, Bakarr, Ibrahim A, Bangura, Abdulai A, Bangura, Camilla, Bangura, Doris, Bangura, James, Belaganahalli, Manjunatha, Bird, Brian H, Chow, Andrew, Conteh, Immah, Coomber, Moinya, Dhanota, Jasjeet, Edwin, Lavalie, Foday, Ibrahim, Gbakima, Aiah A, Gibson, Alexandra, Goldstein, Tracey, Graziano, James, Guetiya Wadoum, Raoul Emeric, Jambai, Amara, Johnny, Jonathan, Kamanda, Emmanuel S, Kamara, Sorie M, Kanu, Marilyn, Kanu, Osman, Kargbo, Dickson, Koroma, Alusine H, Lebbie, Aiah, Lungai, Victor, Mazet, Jonna AK, Mereweather-Thompson, Vanessa, Musa, Jonathan, Nichol, Stuart T, Ontiveros, Victoria, Osborne, Augustus, Patel, Ketan, Robert, Willie, Saidu, Emmanuel, Schuh, Amy J, Sealy, Tara K, Singh, Tushar, Taboy, Celine H, Towner, Jonathan S, Tremeau-Bravard, Alexandre, Turay, Joseph, Turay, Mohamed, Wadsworth, Richard, Williams, Samuel Maxwell Tom   +49 more
core  

Assembly and transport of filovirus nucleocapsids

PLOS Pathogens, 2022
Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs) located in the perinuclear region. The formation of these IBs is induced mainly by the accumulation of the filoviral nucleoprotein NP, which recruits the other nucleocapsid proteins, the polymerase co-factor VP35, the polymerase L, the transcription factor VP30 and
Olga Dolnik, Stephan Becker
openaire   +3 more sources

Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors

Cell Reports, 2018
Summary: Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can protect against infection. It is currently unknown whether natural infection also induces some antibodies with the capacity for antibody-dependent enhancement
Natalia A. Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo I. Santos, Andrew I. Flyak, Philipp A. Ilinykh, Kai Huang, Ndongala M. Lubaki, Palaniappan Ramanathan, James E. Crowe, Jr., Alexander Bukreyev   +10 more
doaj   +1 more source

Modernising epidemic science: enabling patient-centred research during epidemics [PDF]

, 2016
Background: Emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. As an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted ...
Horby, Peter W., Rojek, Amanda M.
core   +3 more sources

Durability of a vesicular stomatitis virus-based marburg virus vaccine in nonhuman primates.

PLoS ONE, 2014
The filoviruses, Marburg virus (MARV) and Ebola virus, causes severe hemorrhagic fever with high mortality in humans and nonhuman primates. A promising filovirus vaccine under development is based on a recombinant vesicular stomatitis virus (rVSV) that ...
Chad E Mire, Joan B Geisbert, Krystle N Agans, Benjamin A Satterfield, Krista M Versteeg, Elizabeth A Fritz, Heinz Feldmann, Lisa E Hensley, Thomas W Geisbert   +8 more
doaj   +1 more source