Results 61 to 70 of about 48,568 (203)

The trimeric Shu complex in C. elegans is an ATPase that remodels RAD51 filaments in the homologous recombination‐associated DNA damage response

The FEBS Journal, EarlyView.
The C. elegans Shu complex (RFS‐1/RIP‐1/SWS‐1) is a DNA‐dependent ATPase that regulates RAD‐51 filaments during homologous recombination. The trimer preferentially binds 5′‐exposed DNA, remodels RAD‐51 filaments via ATP hydrolysis, and stabilizes filaments through ATP binding.
Sam Siu Hang Chu, Guangxin Xing, Kichang Paik, Anton Gartner, Hong Ling   +4 more
wiley   +1 more source

BLIMP‐1 and CD39 expression define human effector memory regulatory T cells in blood and recall responses to viruses

Immunology &Cell Biology, EarlyView.
This study found that BLIMP‐1 is highly expressed in activated effector/memory human regulatory T cells, especially CD39+ Tregs, where it is associated with increased IL‐10 production and a conserved phenotype across blood and lung tissues during immune responses such as SARS‐CoV‐2 infection.
Chansavath Phetsouphanh, Laura Cook, Katherine J. L. Jackson, Deirdre Cuff, Vera Klemm, Bikash Manandhar, Denise C. Hsu, Yin Xu, John J. Zaunders, Anthony D. Kelleher, Nabila Seddiki   +10 more
wiley   +1 more source

The nucleoprotein of Marburg virus is phosphorylated

Journal of General Virology, 1994
The nucleoprotein (NP) of Marburg virus (MBG), a filovirus, is encoded by the gene closest to the 3' end of the non-segmented negative-strand RNA genome. Sequence comparison has indicated that NP is the functional equivalent to the nucleoproteins of paramyxoviruses and rhabdoviruses. Expression of recombinant NP in two eukaryotic systems using vaccinia
S, Becker, S, Huppertz, H D, Klenk, H, Feldmann   +3 more
openaire   +2 more sources

Identifying a Marine-Derived Small-Molecule Nucleoprotein Inhibitor Against Influenza A Virus

Marine Drugs
Influenza A virus (IAV) poses a major threat to global public health, exerting immense pressure on human health and the economy. The IAV nucleoprotein (NP) is an ideal target for antiviral drug development.
Zihan Wang, Yang Zhang, Shangjie Xu, Lishan Sun, Hongwei Zhao, Wei Wang   +5 more
doaj   +1 more source

Phenotypic expression of the gene‐for‐gene interaction in plant pathogenic bacteria: An implication for resistance to bacterial diseases by plants

Agrosystems, Geosciences &Environment, Volume 9, Issue 3, September 2026.
Abstract Plant pathogenic bacteria cause massive losses in agriculture and damage to natural plant habitats. Bacterial pathogens not only reduce crop production, but they also reduce crop quality by releasing toxins into the environment. Pathogenic bacteria that invade plant tissues must overcome the plant's defense mechanisms. Plants possess an innate
Muluken Getahun, Zelalem Bekeko
wiley   +1 more source

Comprehensive Evolutionary and Structural Analysis of the H5N1 Clade 2.4.3.4b Influenza a Virus Based on the Sequences and Data Mining of the Hemagglutinin, Nucleoprotein and Neuraminidase Genes Across Multiple Hosts

Pathogens
H5N1 Influenza A virus continues to pose a significant zoonotic threat, with increasing evidence of interspecies transmission and genetic adaptation. Previous studies primarily focused on avian or human isolates, with limited comprehensive analysis of ...
Kalpana Singh, Yashpal S. Malik, Maged Gomaa Hemida   +2 more
doaj   +1 more source

What happened after the epidemic? Equine influenza surveillance sheds light on sources and seasonal risk in the United Kingdom

Equine Veterinary Journal, Volume 58, Issue 5, Page 1269-1282, September 2026.
Abstract Background The epidemiology of equine influenza (EI) in the United Kingdom has not been systematically described since the 2019 epidemic. Objectives To summarise UK EI surveillance (2020–2024), quantify outbreak seasonality and assess movement‐related sources. Study Design Retrospective observational analysis of national surveillance and horse
Fleur Whitlock, John Grewar, Richard Newton   +2 more
wiley   +1 more source

The Replication Function of Rabies Virus P Protein Is Regulated by a Novel Phosphorylation Site in the N-Terminal N Protein-Binding Region

Viruses
The rabies virus (RABV) phosphoprotein (P protein) has multiple functions, including acting as the essential non-catalytic cofactor of the viral polymerase (L protein) for genome replication and transcription; the principal viral antagonist of the ...
Ericka Tudhope, Camilla M. Donnelly, Ashish Sethi, Cassandra David, Nicholas Williamson, Murray Stewart, Jade K. Forwood, Paul R. Gooley, Gregory W. Moseley   +8 more
doaj   +1 more source

Tyrosine kinase LYN restricts the replication and virulence of influenza A virus by directly phosphorylating viral nucleoprotein

mBio
The continuous antigenic shift and drift of influenza A virus (IAV) result in the emergence of novel strains and drug resistance. Accordingly, it is urgent to develop novel antiviral drugs that target host factors.
Junwen Liu, Jiaxin Huang, Qian Wang, Yanli Wei, Lebin Han, Xin Li, Caoqi Lei, Guohua Deng, Hualan Chen, Qiyun Zhu, Shuai Xu   +10 more
doaj   +1 more source

Nucleoprotein Autoantibodies in Lupus Erythematosus

Journal of Investigative Dermatology, 1985
Autoantibodies against deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) proteins are commonly detected in patients with lupus erythematosus (LE). Antibodies against native DNA are frequently detected in a subset of LE patients with a high prevalence of renal disease.
Provost, Thomas T., Herrera-Esparza, Rafael, Diaz, Luis A.   +2 more
openaire   +2 more sources