Results 81 to 90 of about 81,602 (239)

Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch [PDF]

, 2010
The bacterial flagellar switch that controls the direction of flagellar rotation during chemotaxis has a highly cooperative response. This has previously been understood in terms of the classic two-state, concerted model of allosteric regulation.
F. Bai, R. W. Branch, D. V. Nicolau, T. Pilizota, B. C. Steel, P. K. Maini, R. M. Berry, Monod, Duke, Duke, Changeux, Sowa, Cluzel, Bray, Turner, Alon, Kudo, Block, Scharf, Korobkova, Sowa, Ryu, Korobkova, Lapidus, Block, van Albada, Yuan, Karpen, Dyer, Van Way   +29 more
core   +3 more sources

Sphinganine‐phosphate prevents influenza infection via promoting CD8+ T cells proliferation and activation

VIEW, EarlyView.
This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu, Guiling Yan, Junhong Li, Yuan Yuan, Hong Zhang, Yuchao Zhong, Yuanyuan Peng, Wenjia Zhang, Xiaoyan Su, Changchun Niu, Yang Luo   +10 more
wiley   +1 more source

Dolphin Morbillivirus in Eurasian Otters, Italy [PDF]

, 2019
We report biomolecular evidence of dolphin morbillivirus in 4 wild Eurasian otters (Lutra lutra) from southern Italy; 2 animals showed simultaneous immunohistochemical reactivity against morbilliviral antigen.
Cafiero, Maria Assunta, Carbone, Antonio, Caruso, Marta, Centelleghe, Cinzia, De Riso, Laura, Di Guardo, Giovanni, Galante, Domenico, Guarino, Laura, Mazzariol, Sandro, Padalino, Iolanda, Palazzo, Lucia, Parisi, Antonio, Petrella, Antonio, Troiano, Pasquale   +13 more
core   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Rooting Conifer Genetic Research: An Accessible and Efficient Transformation System

Plant Biotechnology Journal, EarlyView.
ABSTRACT Conifers serve as the cornerstone of global forest ecosystems, yet their genetic transformation faces notorious challenges. To overcome the intrinsic resistance of conifer adventitious roots to Agrobacterium/Rhizobium‐mediated transformation, we systematically and iteratively engineered the binary vector by introducing chimeric Ri plasmid ...
Jing‐Jing Li, Yi‐Mei Zhao, Jia‐Fan Liu, Chen‐He Li, Hui Zhang, Yi‐Tong Song, Quan Zuo, Pei‐Yi Wang, Kai Gao, Dong Meng, Shi‐Hui Niu   +10 more
wiley   +1 more source

Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba [PDF]

, 2013
Archaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present study that it binds more tightly ...
Ingledew, W John, Jelinska, Clare, Petrovic-Stojanovska, Biljana, White, Malcolm F   +3 more
core   +1 more source

Crimean‐Congo Haemorrhagic Fever Virus Exposure in Horses and Donkeys in Border Livestock Markets of Nigeria

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Crimean‐Congo haemorrhagic fever virus (CCHFV) is a tick‐borne zoonotic pathogen of major public health importance in Africa. Although CCHFV exposure has been reported in several livestock species in Nigeria, data on equids remain limited despite their extensive involvement in livestock movement and trade.
David O. Ehizibolo, Olumuyiwa Oyekan, Nicodemus Mkpuma, Habibu Haliru, Ibrahim Garba, Isa Z. Turaki, Samdi Kennedy, Joshua M. Shallangwa, Caleb S. Kilyobas, Abdullahi Mohammed, Musa A. Muhammad, Mansur Abubakar, Maryam Muhammad, Corrie Brown, Bonto Faburay   +14 more
wiley   +1 more source

nucleoproteins

, 2014
Citation: 'nucleoproteins' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.N04252 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source