Results 91 to 100 of about 81,602 (239)

Dissecting immunological mechanisms underlying influenza viral nucleoprotein-induced mucosal immunity against diverse viral strains

Emerging Microbes and Infections
The nucleoprotein (NP) of type A influenza virus (IAV) is highly conserved across all virus strains, making it an attractive candidate antigen for universal vaccines.
Wanyue Zhang, Angela Sloan, Jérémie Prévost, Levi Tamming, Sathya Raman, Annabelle Pfeifle, Caroline Gravel, Wangxue Chen, Anwar M. Hashem, Jianguo Wu, Jingxin Cao, Michael J. W. Johnston, Lisheng Wang, Simon Sauve, Michael Rosu-Myles, Darwyn Kobasa, David Safronetz, Xuguang Li   +17 more
doaj   +1 more source

Live Attenuated Influenza Vaccines engineered to express the nucleoprotein of a recent isolate stimulate human influenza CD8+ T cells more relevant to current infections

Human Vaccines & Immunotherapeutics, 2018
Live attenuated influenza vaccines (LAIV) induce CD8+ T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo ...
D. Korenkov, T. H. O. Nguyen, I. Isakova-Sivak, T. Smolonogina, L. E. Brown, K. Kedzierska, L. Rudenko   +6 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, Volume 16, Issue 5, Page 921-931, May 2026.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Nucleoprotein Autoantibodies in Lupus Erythematosus

Journal of Investigative Dermatology, 1985
Autoantibodies against deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) proteins are commonly detected in patients with lupus erythematosus (LE). Antibodies against native DNA are frequently detected in a subset of LE patients with a high prevalence of renal disease.
Provost, Thomas T., Herrera-Esparza, Rafael, Diaz, Luis A.   +2 more
openaire   +2 more sources

Cross-protection between antigenically distinct H1N1 swine influenza viruses from Europe and North America [PDF]

, 2011
Background An avian-like H1N1 swine influenza virus (SIV) is enzootic in swine populations of Western Europe. The virus is antigenically distinct from H1N1 SIVs in North America that have a classical swine virus-lineage H1 hemagglutinin, as does the ...
Brookes, Brown, Brown, Brown, Brownlee, Dürrwald, Garten, Grebe, Guan, Hinshaw, Hofshagen, Itoh, Kingsford, Kyriakis, Lange, Maurer-Stroh, Miller, Olsen, Olsen, Pensaert, Reed, Sandbulte, Scholtissek, Smith, Takemae, Van Reeth, Van Reeth, Van Reeth, Van Reeth, Van Reeth, Weingartl   +30 more
core   +1 more source

Widespread SARS‐CoV‐2 Transmission Despite Limited Reported Cases and Clinical Disease: Exploring the Role of Pre‐Existing Humoral Immunity to SARS‐CoV‐2 in Eastern Sierra Leone

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background Since December 2019, SARS‐CoV‐2 has infected over 700 million people and caused > 7 million deaths. While much of the global north was severely affected, sub‐Saharan Africa was relatively spared. Possible reasons include a younger population, fewer comorbidities, and pre‐existing immunity.
Robert J. Samuels, Nell G. Bond, Ibrahim Sumah, Donald S. Grant, Mohamed S. Kamara, Lydia Bazzano, Camilo Fernandez, Rodrigo Borrega, Sruti Chandra, Celia R. Glezer, John S. Schieffelin, Troy D. Moon   +11 more
wiley   +1 more source

Identification of lurasidone as a potent inhibitor of severe fever with thrombocytopenia syndrome virus by targeting the viral nucleoprotein

Frontiers in Microbiology
IntroductionSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes acute febrile illness with thrombocytopenia and a high mortality rate in humans.
Ting Cheng, Qingcui Xiao, Jing Cui, Shuangjie Dong, Yuqin Wu, Wenqiang Li, Xinya Yang, Lina Ma, Zhiyong Li, Zhiyong Li, Zhiyong Li, Peng Sun, Peng Sun, Peng Sun, Yinli Xie, Yinli Xie   +15 more
doaj   +1 more source

Coinfection by Ureaplasma spp., Photobacterium damselae and an Actinomyces-like microorganism in a bottlenose dolphin (Tursiops truncatus) with pleuropneumonia stranded along the Adriatic coast of Italy [PDF]

, 2016
A case of pleuropneumonia is reported in an adult male bottlenose dolphin (Tursiops truncatus) found stranded in 2014 along the Central Adriatic coast of Italy.
Camm\ue0, Cesare, Curini, Valentina, Di Francesco, Cristina Esmeralda, Di Francesco, Gabriella, Di Guardo, Giovanni, Di Provvido, Andrea, Ferri, Nicola, Mazzariol, Sandro, Proietto, Umberto   +8 more
core   +1 more source

Inhibition of influenza virus infection by garlic oil and juice in cell culture

JSFA reports, Volume 6, Issue 5, Page 193-197, May 2026.
Abstract Background Influenza virus infections are a significant global health and economic burden. Garlic (Allium sativum) has been proposed to have antimicrobial properties. Raw garlic consumption has been widely advocated on the internet to fight influenza by many public health agencies, information of which is easily accessible by the public. There
Carla Breen, Timothy Smith, Nick Diamantopoulos, Julie McAuley   +3 more
wiley   +1 more source

Dimerization of Rabies Virus Phosphoprotein and Phosphorylation of Its Nucleoprotein Enhance Their Binding Affinity

Viruses
The dynamic interplay between a multimeric phosphoprotein (P) and polymeric nucleoprotein (N) in complex with the viral RNA is at the heart of the functioning of the RNA-synthesizing machine of negative-sense RNA viruses of the order Mononegavirales.
Euripedes de Almeida Ribeiro, Cédric Leyrat, Francine C. A. Gérard, Marc Jamin   +3 more
doaj   +1 more source