Results 71 to 80 of about 60,064 (253)

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

The nucleoprotein of Marburg virus is phosphorylated

Journal of General Virology, 1994
The nucleoprotein (NP) of Marburg virus (MBG), a filovirus, is encoded by the gene closest to the 3' end of the non-segmented negative-strand RNA genome. Sequence comparison has indicated that NP is the functional equivalent to the nucleoproteins of paramyxoviruses and rhabdoviruses. Expression of recombinant NP in two eukaryotic systems using vaccinia
S, Becker, S, Huppertz, H D, Klenk, H, Feldmann   +3 more
openaire   +2 more sources

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Dissecting immunological mechanisms underlying influenza viral nucleoprotein-induced mucosal immunity against diverse viral strains

Emerging Microbes and Infections
The nucleoprotein (NP) of type A influenza virus (IAV) is highly conserved across all virus strains, making it an attractive candidate antigen for universal vaccines.
Wanyue Zhang, Angela Sloan, Jérémie Prévost, Levi Tamming, Sathya Raman, Annabelle Pfeifle, Caroline Gravel, Wangxue Chen, Anwar M. Hashem, Jianguo Wu, Jingxin Cao, Michael J. W. Johnston, Lisheng Wang, Simon Sauve, Michael Rosu-Myles, Darwyn Kobasa, David Safronetz, Xuguang Li   +17 more
doaj   +1 more source

Colonic Barrier Dysfunction and Inflammation Induced by Nano‐/Micro‐Plastics Fibers in Mice via the FAK/NF‐κB/iNOS and TLR4/NF‐κB/iNOS Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT As emerging environmental contaminants, nano‐ and micro‐plastics (NMPs) have drawn increasing research attention due to potential hazards to organisms. Particle shape is a key factor influencing the toxic effects of NMPs, and NMPs of different shapes cause varying degrees of tissue damage. We investigated the specific mechanisms of polystyrene
Yuting Li, Shibo Bao, Puyang Huang, Jiahui Wang, Hongfeng Li, Yahong Liu, Kai Wang, Jianjun Du, Lingjun Yan, Guowei Pan, Wei Sun   +10 more
wiley   +1 more source

The role of nucleoprotein oligomerization for the replication of arenaviruses

, 2013
Das Nukleoprotein der Arenaviren erfüllt zentrale Aufgaben im viralen Replikationszyklus. Dazu gehört die Enkapsidierung des viralen Genoms und die Regulation von Transkription und Replikation sowie die Interaktion mit dem Matrixprotein und die ...
Lennartz, Frank (1023319578)
core   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Identification of lurasidone as a potent inhibitor of severe fever with thrombocytopenia syndrome virus by targeting the viral nucleoprotein

Frontiers in Microbiology
IntroductionSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes acute febrile illness with thrombocytopenia and a high mortality rate in humans.
Ting Cheng, Qingcui Xiao, Jing Cui, Shuangjie Dong, Yuqin Wu, Wenqiang Li, Xinya Yang, Lina Ma, Zhiyong Li, Zhiyong Li, Zhiyong Li, Peng Sun, Peng Sun, Peng Sun, Yinli Xie, Yinli Xie   +15 more
doaj   +1 more source

The Early Regenerative Events in the Human Tympanic Membrane After In Vivo Traumatization

The Laryngoscope, EarlyView.
At 20 h after in vivo traumatization a regenerative response in the human tympanic membrane is activated. The results show an upregulated proliferation activity in the UPT in early healing and confirm the previously described regenerative regions of the annulus and malleus.
Elnaz Sepehri, Cecilia Engmér Berglin, Yan Liu, Per Olof Eriksson, Magnus von Unge, Julia Arebro   +5 more
wiley   +1 more source

Dimerization of Rabies Virus Phosphoprotein and Phosphorylation of Its Nucleoprotein Enhance Their Binding Affinity

Viruses
The dynamic interplay between a multimeric phosphoprotein (P) and polymeric nucleoprotein (N) in complex with the viral RNA is at the heart of the functioning of the RNA-synthesizing machine of negative-sense RNA viruses of the order Mononegavirales.
Euripedes de Almeida Ribeiro, Cédric Leyrat, Francine C. A. Gérard, Marc Jamin   +3 more
doaj   +1 more source