Results 51 to 60 of about 61,031 (268)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

MiR-130c-5p targets the SHVV n gene and upregulates immune cytokines (IL-6, IL-22, IL-1β) to inhibit viral replication

Frontiers in Immunology
BackgroundSnakehead vesiculovirus (SHVV) has led to huge economic losses in snakehead aquaculture, and its pathogenic mechanisms is still not fully understood.
Jin Wei, Yan Ji, Yaqian Bai, Rui Cheng, Jiaqi Zhang, Xianqin Hu, Chi Zhang   +6 more
doaj   +1 more source

Nucleoprotein-based nanoscale assembly [PDF]

Proceedings of the National Academy of Sciences, 1997
A system for addressing in the construction of macromolecular assemblies can be based on the biospecificity of DNA (cytosine-5) methyltransferases and the capacity of these enzymes to form abortive covalent complexes at targeted 5-fluorocytosine residues in DNA.
S S, Smith, L, Niu, D J, Baker, J A, Wendel, S E, Kane, D S, Joy   +5 more
openaire   +2 more sources

Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments [PDF]

, 1999
The influenza virus genome is transcribed in the nuclei of infected cells but assembled into progeny virions in the cytoplasm. This is reflected in the cellular distribution of the virus nucleoprotein (NP), a protein which encapsidates genomic RNA to ...
Pope, Brian, Digard, Paul, Medcalf, Liz, Weeds, Alan, Elton, Debra, Bishop, Konrad   +5 more
core  

Multiplexed Detection of Respiratory Viruses Using Surface Plasmon Resonance Spectroscopy With Ultrathin Carbon Nanomembranes

Advanced Healthcare Materials, EarlyView.
An ultrathin azide‐functionalized carbon nanomembrane (N3‐CNM) provides a versatile biointerface for antibody immobilization on gold SPR sensors. Integrated with a multichannel SPR platform, the functionalized surface enables label‐free, simultaneous detection of SARS‐CoV‐2, Influenza A, and RSV antigens, demonstrating the potential of CNM‐based ...
Ghazaleh Eshaghi, Hamid Reza Rasouli, David Kaiser, Tobias Fischer, Katrin Frankenfeld, Abhishek Sharma, Andrey Turchanin   +6 more
wiley   +1 more source

Phosphorylation Status of Tyrosine 78 Residue Regulates the Nuclear Export and Ubiquitination of Influenza A Virus Nucleoprotein

Frontiers in Microbiology, 2019
Phosphorylation and dephosphorylation of nucleoprotein (NP) play significant roles in the life cycle of influenza A virus (IAV), and the biological functions of each phosphorylation site on NP are not exactly the same in controlling viral replication ...
Liang Cui, Liang Cui, Weinan Zheng, Minghui Li, Minghui Li, Xiaoyuan Bai, Xiaoyuan Bai, Wenxian Yang, Wenxian Yang, Jing Li, Jing Li, Wenhui Fan, George Fu Gao, George Fu Gao, George Fu Gao, Lei Sun, Lei Sun, Wenjun Liu, Wenjun Liu   +18 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Amino Acid Substitution K470R in the Nucleoprotein Increases the Virulence of H5N1 Influenza A Virus in Mammals

Frontiers in Microbiology, 2017
H5N1 is a highly pathogenic influenza A virus (IAV) and poses a major threat to the public health. The nucleoprotein (NP) has a multiple functions during the viral life cycle, however, the precise role of NP mutants in viral replication and pathogenicity
Lin Chen, Lin Chen, Chengmin Wang, Jing Luo, Meng Li, Meng Li, Huimin Liu, Huimin Liu, Na Zhao, Na Zhao, Jingjing Huang, Xili Zhu, Guoyao Ma, Guoyao Ma, Guohui Yuan, Hongxuan He   +15 more
doaj   +1 more source

Genome encapsidation by orthobunyavirus nucleoproteins [PDF]

Proceedings of the National Academy of Sciences, 2013
All negative-sense, single-stranded RNA (−ssRNA) viruses encode a nucleoprotein (NP), the major function of which is to bind viral RNAs and encapsidate them as ribonucleoprotein complexes (RNPs) (1, 2). Consequently, the genomes of −ssRNA viruses do not exist as naked RNA but rather as protein–RNA complexes with high-order structures. In PNAS, Li et al.
Wenjie, Zheng, Yizhi Jane, Tao
openaire   +2 more sources