Results 1 to 10 of about 58,013 (257)

Molecular recognition requires dimerization of a VHH antibody

MAbs, 2023
Camelid heavy-chain-only antibodies are a unique class of antibody that possesses only a single variable domain (termed VHH) for antigen recognition.
Andrew B Herr, James R Horn
exaly   +6 more sources

VHH Antibodies: Reagents for Mycotoxin Detection in Food Products [PDF]

Sensors, 2018
Mycotoxins are the toxic secondary metabolites produced by fungi and they are a worldwide public health concern. A VHH antibody (or nanobody) is the smallest antigen binding entity and is produced by heavy chain only antibodies.
Jia Wang, Xiaohong Wang
exaly   +5 more sources

Bispecific single-domain antibody (VHH) fused with human IgG1 Fc with dual specificity effectively neutralize Naja Kaouthia venom. [PDF]

PLoS Neglected Tropical Diseases
Naja kaouthia, or the monocled cobra, is one of the most medically important snakes in Thailand, responsible for approximately 17% of snakebite cases. Conventional horse-derived antivenoms are lifesaving, yet they may trigger severe allergic reactions ...
Kanokporn Pothisamutyothin, Sirisak Sathorn, Ratchana Boonmee, Wichit Thaveekarn, Wanatchaporn Arunmanee   +4 more
doaj   +2 more sources

Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection [PDF]

Frontiers in Immunology, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Dorien De Vlieger, Dorien De Vlieger, Dorien De Vlieger, Katja Hoffmann, Inge Van Molle, Inge Van Molle, Wim Nerinckx, Wim Nerinckx, Lien Van Hoecke, Lien Van Hoecke, Marlies Ballegeer, Marlies Ballegeer, Marlies Ballegeer, Sarah Creytens, Sarah Creytens, Sarah Creytens, Han Remaut, Han Remaut, Hartmut Hengel, Bert Schepens, Bert Schepens, Xavier Saelens, Xavier Saelens, Xavier Saelens   +23 more
doaj   +3 more sources

Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

Protein Science, 2022
The camelid single domain antibody, referred to VHH or Nanobody, is considered a versatile tool for various biotechnological and clinical applications because of its favorable biophysical properties. To take advantage of these characteristics and for its
Seisho Kinoshita, Makoto Nakakido, Daisuke Kuroda   +2 more
exaly   +2 more sources

Characterization of plant produced VHH antibodies against cobra venom toxins for antivenom therapy

Biotechnology Reports
Cobra (Naja kaouthia) venom contains many toxins including α-neurotoxin (αNTX) and phospholipase A2 (PLA2), which can cause neurodegeneration, respiratory failure, and even death.
Sarocha Vitayathikornnasak, Kaewta Rattanapisit, Ashwini Malla, Pipob Suwanchaikasem, Richard Strasser, Narach Khorattanakulchai, Kanokporn Pothisamutyothin, Wanatchaporn Arunmanee, Waranyoo Phoolcharoen   +8 more
doaj   +2 more sources

Contribution of CDR3 in characterization of camelid VHH and its aflatoxin B1-binding interaction

Food Chemistry Advances
The single variable domain of heavy chain (VHH) antibodies, owing to their unique properties, has gained attention in immunoassays. However, compared with macromolecule antigens, in the case of small molecule haptens, such as aflatoxin B1 (AFB1), the ...
Xiaohong Wang, Jia Wang
exaly   +3 more sources

Complete Neutralization of Tetanus Neurotoxin by Alpaca-Derived Trivalent Nanobodies Aimed at Veterinary Medical Applications [PDF]

Veterinary Sciences
Tetanus is a zoonotic disease posing significant threats to both humans and animals, particularly horses, sheep, and ruminants. Current antitoxin therapies rely on animal-derived immunoglobulins, presenting challenges including animal welfare concerns ...
Chiyomi Sakamoto, Chie Shitada, Norihiko Kiyose, Nobuo Miyazaki, Sena Kamesawa, Hiroshi Morioka, Kazunori Morokuma, Kazuhiko Tomokiyo, Motohide Takahashi   +8 more
doaj   +2 more sources

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models [PDF]

Frontiers in Immunology
BackgroundPancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with a 5-year survival rate below 10%, largely due to late-stage diagnosis and the limited effectiveness of conventional therapies such as surgery, chemotherapy, and ...
Ying Xing, Ying Xing, Gangqiang Shi, Zhengli Li, Xiancheng Liu, Linghu Nie, Yu Zhang, Yiqin Song, Shilin Sun, Mike K. S. Chan, Mike K. S. Chan, Mike K. S. Chan, Mike K. S. Chan, Michelle B. F. Wong, Michelle B. F. Wong, Krista Casazza, Jonathan R. T. Lakey, Jonathan R. T. Lakey, Yuping Chen, Xuekai Zhu, Yunfeng Feng   +20 more
doaj   +2 more sources

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

Antibodies, 2019
Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization.
Lucy Rutten, Laura E Mccoy, Christophe Caillat   +2 more
exaly   +3 more sources