A comparison of the binding sites of antibodies and single-domain antibodies
Frontiers in Immunology, 2023 Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity.
Gemma L. Gordon +5 more
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Transportation of Single-Domain Antibodies through the Blood–Brain Barrier
Biomolecules, 2021 Single-domain antibodies derive from the heavy-chain-only antibodies of Camelidae (camel, dromedary, llama, alpaca, vicuñas, and guananos; i.e., nanobodies) and cartilaginous fishes (i.e., VNARs).
Eduardo Ruiz-López +1 more
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Single Domain Antibodies as New Biomarker Detectors [PDF]
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
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Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR
Pharmaceutics, 2020 Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation.
Elodie Pothin +2 more
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An Inside Job: Applications of Intracellular Single Domain Antibodies [PDF]
Biomolecules, 2020 Sera of camelid species contain a special kind of antibody that consists only of heavy chains. The variable antigen binding domain of these heavy chain antibodies can be expressed as a separate entity, called a single domain antibody that is ...
Eline Soetens +2 more
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Immunogenicity and humanization of single‐domain antibodies [PDF]
The FEBS Journal, 2021 Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark heavy‐chain antibodies, have many desirable properties as components of biologic drugs. However, their sequences may increase the risk of immunogenicity and antidrug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development ...
Rossotti, Martin A. +3 more
openaire +2 more sources
Single-domain antibodies make a difference [PDF]
Science, 2021 A double hit with one antibody construct may avoid viral ...
Xavier, Saelens, Bert, Schepens
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Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. [PDF]
PLoS ONE, 2016 Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics.
George P Anderson +7 more
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Integrating Single Domain Antibodies into Field-Deployable Rapid Assays
Antibodies, 2022 Single domain antibodies (sdAb) are the recombinant variable heavy domains derived from camelid heavy-chain antibodies. While they have binding affinities equivalent to conventional antibodies, sdAb are only one-tenth the size and possess numerous ...
George P. Anderson +3 more
doaj +1 more source
Development and evaluation of single domain antibodies for vaccinia and the L1 antigen. [PDF]
PLoS ONE, 2014 There is ongoing interest to develop high affinity, thermal stable recognition elements to replace conventional antibodies in biothreat detection assays. As part of this effort, single domain antibodies that target vaccinia virus were developed.
Scott A Walper +4 more
doaj +1 more source