Results 11 to 20 of about 606,803 (250)
Immunogenicity and humanization of single‐domain antibodies [PDF]
The FEBS Journal, 2021 Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark heavy‐chain antibodies, have many desirable properties as components of biologic drugs. However, their sequences may increase the risk of immunogenicity and antidrug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development ...
Rossotti, Martin A. +3 more
openaire +2 more sources
Single-domain antibodies make a difference [PDF]
Science, 2021 A double hit with one antibody construct may avoid viral ...
Xavier, Saelens, Bert, Schepens
openaire +2 more sources
Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. [PDF]
PLoS ONE, 2016 Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics.
George P Anderson +7 more
doaj +1 more source
Integrating Single Domain Antibodies into Field-Deployable Rapid Assays
Antibodies, 2022 Single domain antibodies (sdAb) are the recombinant variable heavy domains derived from camelid heavy-chain antibodies. While they have binding affinities equivalent to conventional antibodies, sdAb are only one-tenth the size and possess numerous ...
George P. Anderson +3 more
doaj +1 more source
Development and evaluation of single domain antibodies for vaccinia and the L1 antigen. [PDF]
PLoS ONE, 2014 There is ongoing interest to develop high affinity, thermal stable recognition elements to replace conventional antibodies in biothreat detection assays. As part of this effort, single domain antibodies that target vaccinia virus were developed.
Scott A Walper +4 more
doaj +1 more source
Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses
iScience, 2022 Summary: We report robust SARS-CoV2 neutralizing sdAbs targeting the viral peptides encompassing the polybasic cleavage site (CSP) and in the receptor binding domain (RBD) of the spike (S) protein.
Sudhakar Singh +8 more
doaj +1 more source
Single Domain Antibodies as New Biomarker Detectors
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
doaj +1 more source
An Inside Job: Applications of Intracellular Single Domain Antibodies
Biomolecules, 2020 Sera of camelid species contain a special kind of antibody that consists only of heavy chains. The variable antigen binding domain of these heavy chain antibodies can be expressed as a separate entity, called a single domain antibody that is ...
Eline Soetens +2 more
doaj +1 more source
Single‐Domain Antibodies and Their Utility
Current Protocols in Immunology, 2013 AbstractEngineered monoclonal antibody fragments have gained market attention due to their versatility and tailor‐made potential and are now considered to be an important part of future immunobiotherapeutics. Single‐domain antibodies (sdAbs), also known as nanobodies, are derived from VHHs [variable domains (V) of heavy‐chain‐only antibodies (HCAb)] of
Baral, Toya Nath +2 more
openaire +4 more sources
Bglbrick strategy for the construction of single domain antibody fusions
Heliyon, 2017 Single domain antibodies, recombinantly expressed variable domains derived from camelid heavy chain antibodies, are often expressed as multimers for detection and therapeutic applications.
Ellen R. Goldman +3 more
doaj +1 more source