Results 11 to 20 of about 837,563 (288)

Transportation of Single-Domain Antibodies through the Blood–Brain Barrier

Biomolecules, 2021
Single-domain antibodies derive from the heavy-chain-only antibodies of Camelidae (camel, dromedary, llama, alpaca, vicuñas, and guananos; i.e., nanobodies) and cartilaginous fishes (i.e., VNARs).
Eduardo Ruiz-López, Alberto J. Schuhmacher   +1 more
doaj   +3 more sources

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity [PDF]

Medical Microbiology and Immunology, 2009
Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave.
Janusz Wesolowski, Vanina Alzogaray, Jan Reyelt, Mandy Unger, Karla Juarez, Mariela Urrutia, Ana Cauerhff, Welbeck Danquah, Björn Rissiek, Felix Scheuplein, Nicole Schwarz, Sahil Adriouch, Olivier Boyer, Michel Seman, Alexei Licea, David V. Serreze, Fernando A. Goldbaum, Friedrich Haag, Friedrich Koch-Nolte, OH Brekke, C Hamers-Casterman, S Muyldermans, P Holliger, A Desmyter, E De Genst, TT Wu, MM Harmsen, A Pini, HR Hoogenboom, V Cortez-Retamozo, M Dumoulin, EK Conrath, U Rothbauer, A Olichon, K Coppieters, N Pant, D Gueorguieva, SA Jobling, B Serruys, M Feldmann, N Lonberg, A Drucker, JW Goding, M Salmi, D Corda, A Zolkiewska, F Di Virgilio, F Koch-Nolte, S Adriouch, F Koch-Nolte, F Scheuplein, S Adriouch, M Seman, V Ghetie, G Behar, AJ Groot, A Muruganandam, A Abulrob, V Cortez-Retamozo, K Omidfar, R Roovers, L Huang, BM Tijink, F Rahbarizadeh, D Ahmadvand, MA Palladino, DR Maass, W Wolfson, JJ Hulstein, D Schenk, M Dumoulin, P Lafaye, G Habicht, R Klooster, C Cohen-Saidon, C Avignolo, AJ Groot, AJ Groot, P Verheesen, D Laune, A Marquardt, DA Laplagne, LM Zarebski, DP Simmons, T Gura, K Strebhardt, K Aktories, ER Goldman, JL Liu, ER Goldman, M El Khattabi, RA Harrison, F Meddeb-Mouelhi, RA Harrison, CS Stewart, I Hmila, PJ Doyle, S Spinelli, RC Ladenson, GP Anderson, N Alvarez-Rueda, DM Goldenberg, A Forsman, L Garaicoechea, MM Harmsen, MM Harmsen, A Hultberg, HJ de Haard, AM Ledeboer, S Dekker, LJ Sherwood, MM Harmsen, A Szynol, C Krüger, KV Korotkov, AY Lam, S Spinelli, KE Conrath, B Stijlemans, TN Baral, D Saerens, L Ratier, N Deckers, E Dolk, AS Greenberg, C Vincke, X Zou, R Janssens, EG Hofman, LO Gainkam, F Rahbarizadeh, S Winichayakul, D Saerens, D Saerens, PH Chan, A Chartier, S van Koningsbruggen, JL Liu, JM van der Vaart, MM Harmsen, KA Henderson, W DeLano, RL Stanfield, AT Hadfield, BC Braden, MR Bazl, U Rothbauer   +146 more
core   +6 more sources

Single-domain antibodies for brain targeting [PDF]

, 2014
Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant production. sdAbs have been forged into multivalent and multispecif ic therapeutics, or targeting moieties, that are able to shuttle their linked therapeutic ...
Lalatsa, Katerina, Moreira Leite, Diana
core   +3 more sources

Single domain antibodies from camelids in the treatment of microbial infections [PDF]

Frontiers in Immunology
Infectious diseases continue to pose significant global health challenges. In addition to the enduring burdens of ailments like malaria and HIV, the emergence of nosocomial outbreaks driven by antibiotic-resistant pathogens underscores the ongoing ...
Henri De Greve, Antonella Fioravanti, Antonella Fioravanti, Antonella Fioravanti   +3 more
doaj   +2 more sources

Single-domain antibodies make a difference [PDF]

Science, 2021
A double hit with one antibody construct may avoid viral ...
Xavier, Saelens, Bert, Schepens
openaire   +2 more sources

Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. [PDF]

PLoS ONE, 2016
Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics.
George P Anderson, Daniel D Teichler, Dan Zabetakis, Lisa C Shriver-Lake, Jinny L Liu, Stephen G Lonsdale, Sarah A Goodchild, Ellen R Goldman   +7 more
doaj   +1 more source

Immunogenicity and humanization of single‐domain antibodies [PDF]

The FEBS Journal, 2021
Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark heavy‐chain antibodies, have many desirable properties as components of biologic drugs. However, their sequences may increase the risk of immunogenicity and antidrug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development ...
Rossotti, Martin A., Bélanger, Kasandra, Henry, Kevin A., Tanha, Jamshid   +3 more
openaire   +2 more sources

Integrating Single Domain Antibodies into Field-Deployable Rapid Assays

Antibodies, 2022
Single domain antibodies (sdAb) are the recombinant variable heavy domains derived from camelid heavy-chain antibodies. While they have binding affinities equivalent to conventional antibodies, sdAb are only one-tenth the size and possess numerous ...
George P. Anderson, Lisa C. Shriver-Lake, Jinny L. Liu, Ellen R. Goldman   +3 more
doaj   +1 more source

Development and evaluation of single domain antibodies for vaccinia and the L1 antigen. [PDF]

PLoS ONE, 2014
There is ongoing interest to develop high affinity, thermal stable recognition elements to replace conventional antibodies in biothreat detection assays. As part of this effort, single domain antibodies that target vaccinia virus were developed.
Scott A Walper, Jinny L Liu, Daniel Zabetakis, George P Anderson, Ellen R Goldman   +4 more
doaj   +1 more source

Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses

iScience, 2022
Summary: We report robust SARS-CoV2 neutralizing sdAbs targeting the viral peptides encompassing the polybasic cleavage site (CSP) and in the receptor binding domain (RBD) of the spike (S) protein.
Sudhakar Singh, Surbhi Dahiya, Yuviana J. Singh, Komal Beeton, Ayush Jain, Roman Sarkar, Abhishek Dubey, Azeez Tehseen, Sharvan Sehrawat   +8 more
doaj   +1 more source