Results 21 to 30 of about 1,285 (207)

Application Progress of the Single Domain Antibody in Medicine

International Journal of Molecular Sciences, 2023
The camelid-derived single chain antibody (sdAb), also termed VHH or nanobody, is a unique, functional heavy (H)-chain antibody (HCAb). In contrast to conventional antibodies, sdAb is a unique antibody fragment consisting of a heavy-chain variable domain. It lacks light chains and a first constant domain (CH1).
Huaping Tang, Yuan Gao, Jiangyuan Han
openaire   +2 more sources

sdAb-DB: The Single Domain Antibody Database [PDF]

ACS Synthetic Biology, 2018
The Single Domain Antibody Database, or sdAb-DB, ( www.sdab-db.ca ) is the first freely available repository for single domain antibodies and related classes of proteins. Due to their small size, modular structure, and ease of expression, single domain antibodies (sdAb) have a wide range of applications, including as a rational design tool, and are ...
Emily E. Wilton, Michael P. Opyr, Senthilkumar Kailasam, Ronja F. Kothe, Hans-Joachim Wieden   +4 more
openaire   +2 more sources

Progress of Single-domain Antibodies in Molecular Imaging of Tumors

Zhongliu Fangzhi Yanjiu, 2019
A single-domain antibody (sdAb) is the variable region extracted from antibodies with only heavy chains found in camelid serum. Single-domain antibodies have the characteristics of easy expression, good solubility, great stability and weak immunogenicity.
ZHANG Meixin, LIU Teli, GUO Xiaoyi, XU Xiaoxia, ZHU Hua, YANG Zhi   +5 more
doaj   +1 more source

Delicate balance among thermal stability, binding affinity, and conformational space explored by single-domain VHH antibodies

Scientific Reports, 2021
The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they ...
Emina Ikeuchi, Daisuke Kuroda, Makoto Nakakido, Akikazu Murakami, Kouhei Tsumoto   +4 more
doaj   +1 more source

Selection of intracellular single-domain antibodies targeting the HIV-1 Vpr protein by cytoplasmic yeast two-hybrid system.

PLoS ONE, 2014
The targeting of HIV-1 using antibodies is of high interest as molecular tools to better understand the biology of the virus or as a first step toward the design of new inhibitors targeting critical viral intracellular proteins.
Julie Matz, Cécile Hérate, Jérôme Bouchet, Nelson Dusetti, Odile Gayet, Daniel Baty, Serge Benichou, Patrick Chames   +7 more
doaj   +1 more source

Enhancing neutralizing activity against influenza H1N1/PR8 by engineering a single-domain VL-M2 specific into a bivalent form.

PLoS ONE, 2022
Flu disease, with high mortality and morbidity, is caused by the influenza virus. Influenza infections are most effectively prevented through vaccination, but it requires annual reformulation due to the antigenic shift or drift of hemagglutinin and ...
Phuong Thi Hoang, Quynh Xuan Thi Luong, Seungchan Cho, Yongjun Lee, Kyungho Na, Ramadhani Qurrota Ayun, Thuy Thi Bich Vo, Taehyun Kim, Sukchan Lee   +8 more
doaj   +1 more source

Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody.

PLoS ONE, 2014
Single domain antibodies are the small recombinant variable domains derived from camelid heavy-chain-only antibodies. They are renowned for their stability, in large part due to their ability to refold following thermal or chemical denaturation.
Dan Zabetakis, Mark A Olson, George P Anderson, Patricia M Legler, Ellen R Goldman   +4 more
doaj   +1 more source

Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin

Antibodies, 2019
Influenza B virus (IBV) circulates in the human population and causes considerable disease burden worldwide, each year. Current IBV vaccines can struggle to mount an effective cross-reactive immune response, as strains become mismatched, due to constant ...
Walter Ramage, Tiziano Gaiotto, Christina Ball, Paul Risley, George W. Carnell, Nigel Temperton, Chung Y. Cheung, Othmar G. Engelhardt, Simon E. Hufton   +8 more
doaj   +1 more source

Construction of Novel Bispecific Single-Domain Antibodies (BiSdAbs) with Potent Antiangiogenic Activities

Pharmaceutical Fronts, 2020
The development of bispecific antibodies (BsAbs) has had a profound impact on cancer immunotherapy. Single-domain antibodies (SdAbs) could offer advantages over other antibody formats for the generation of a BsAbs, such as small size (∼12–15 kDa), with ...
Xianglei Liu, Tianyuan Sun, Qiuhan Ge, Jianwei Zhu   +3 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source