A comparison of the binding sites of antibodies and single-domain antibodies [PDF]
Frontiers in Immunology, 2023 Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity.
Gemma L. Gordon +5 more
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Species-Dependent Structural Variations in Single-Domain Antibodies [PDF]
AntibodiesBackground/Objectives: Single-domain antibodies (sdAbs) are derived from camelid heavy-chain antibodies (HCAb). Their small size, high stability, and ease of production, among other properties, makes them highly valuable in biomedical research and ...
Marta Baselga +3 more
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Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR
Pharmaceutics, 2020 Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation.
Elodie Pothin +2 more
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Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses [PDF]
Nature CommunicationsInfluenza B viruses are antigenically diverse and contribute significantly to the annual influenza burden. Here we report influenza B virus neutralizing single-domain antibodies that target highly conserved regions of the hemagglutinin and neuraminidase.
Arne Matthys +9 more
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An Inside Job: Applications of Intracellular Single Domain Antibodies
Biomolecules, 2020 Sera of camelid species contain a special kind of antibody that consists only of heavy chains. The variable antigen binding domain of these heavy chain antibodies can be expressed as a separate entity, called a single domain antibody that is ...
Eline Soetens +2 more
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Inhibition of tau neuronal internalization using anti-tau single domain antibodies [PDF]
Nature CommunicationsIn Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons.
Clément Danis +12 more
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Single-domain antibodies as therapeutics for solid tumor treatment [PDF]
Acta Pharmaceutica Sinica BSingle-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies.
Mingkai Wang, Tianlei Ying, Yanling Wu
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Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB
Herlinde Dierick +11 more
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Single domain antibodies from camelids in the treatment of microbial infections [PDF]
Frontiers in ImmunologyInfectious diseases continue to pose significant global health challenges. In addition to the enduring burdens of ailments like malaria and HIV, the emergence of nosocomial outbreaks driven by antibiotic-resistant pathogens underscores the ongoing ...
Henri De Greve +3 more
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Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. [PDF]
PLoS ONE, 2016 Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics.
George P Anderson +7 more
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