A comparison of the binding sites of antibodies and single-domain antibodies [PDF]
Frontiers in Immunology, 2023 Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity.
Gemma L. Gordon +5 more
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Selection of intracellular single-domain antibodies targeting the HIV-1 Vpr protein by cytoplasmic yeast two-hybrid system. [PDF]
PLoS ONE, 2014 The targeting of HIV-1 using antibodies is of high interest as molecular tools to better understand the biology of the virus or as a first step toward the design of new inhibitors targeting critical viral intracellular proteins.
Julie Matz +7 more
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Species-Dependent Structural Variations in Single-Domain Antibodies [PDF]
AntibodiesBackground/Objectives: Single-domain antibodies (sdAbs) are derived from camelid heavy-chain antibodies (HCAb). Their small size, high stability, and ease of production, among other properties, makes them highly valuable in biomedical research and ...
Marta Baselga +3 more
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Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses [PDF]
Nature CommunicationsInfluenza B viruses are antigenically diverse and contribute significantly to the annual influenza burden. Here we report influenza B virus neutralizing single-domain antibodies that target highly conserved regions of the hemagglutinin and neuraminidase.
Arne Matthys +9 more
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Single domain antibodies: promising experimental and therapeutic tools in infection and immunity [PDF]
Medical Microbiology and Immunology, 2009 Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave.
Ana Cauerhff +2 more
exaly +6 more sources
Transportation of Single-Domain Antibodies through the Blood–Brain Barrier
Biomolecules, 2021 Single-domain antibodies derive from the heavy-chain-only antibodies of Camelidae (camel, dromedary, llama, alpaca, vicuñas, and guananos; i.e., nanobodies) and cartilaginous fishes (i.e., VNARs).
Eduardo Ruiz-López +1 more
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Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR
Pharmaceutics, 2020 Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation.
Elodie Pothin +2 more
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Inhibition of tau neuronal internalization using anti-tau single domain antibodies [PDF]
Nature CommunicationsIn Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons.
Clément Danis +12 more
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Single-domain antibodies as therapeutics for solid tumor treatment [PDF]
Acta Pharmaceutica Sinica BSingle-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies.
Mingkai Wang, Tianlei Ying, Yanling Wu
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Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB
Herlinde Dierick +11 more
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