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Applications of nanobodies in brain diseases
Frontiers in Immunology, 2022 Nanobodies are antibody fragments derived from camelids, naturally endowed with properties like low molecular weight, high affinity and low immunogenicity, which contribute to their effective use as research tools, but also as diagnostic and therapeutic ...
Fang Zheng +7 more
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Cloning and characterisation of nanobodies against the coat protein of Zucchini yellow mosaic virus
Plant Protection Science, 2018 Zucchini yellow mosaic virus (ZYMV), in the family Potyviridae, causes an economically important disease. Antibodies are valuable reagents for diagnostic assays to rapidly detect viral infection.
Adel M. Zakri +8 more
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Frontiers in Bioengineering and Biotechnology, 2022 Nanobodies® (VHH antibodies), are small peptides that represent the antigen binding domain, VHH of unique single domain antibodies (heavy chain only antibodies, HcAb) derived from camelids.
Marco Pitino +4 more
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Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies
Frontiers in Immunology, 2021 The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of tumor banks remains limited.
Sayda Dhaouadi +18 more
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Molecular and Cellular Endocrinology, 2019 The family of G protein-coupled receptors (GPCRs) is the largest class of membrane proteins and an important drug target due to their role in many (patho)physiological processes. Besides small molecules, GPCRs can be targeted by biologicals including antibodies and antibody fragments.
De Groof, Timo +3 more
openaire +2 more sources
Visual and High-Efficiency Secretion of SARS-CoV-2 Nanobodies with Escherichia coli
BiomoleculesNanobodies have gained attention as potential therapeutic and diagnostic agents for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to their ability to bind and neutralize the virus.
Shuai Zhao +8 more
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Nanobodies in cell-mediated immunotherapy: On the road to fight cancer
Frontiers in Immunology, 2023 The immune system is essential in recognizing and eliminating tumor cells. The unique characteristics of the tumor microenvironment (TME), such as heterogeneity, reduced blood flow, hypoxia, and acidity, can reduce the efficacy of cell-mediated immunity.
Amirhosein Maali +9 more
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Iterative In Silico Screening for Optimizing Stable Conformation of Anti-SARS-CoV-2 Nanobodies
PharmaceuticalsNanobodies (Nbs or VHHs) are single-domain antibodies (sdAbs) derived from camelid heavy-chain antibodies. Nbs have special and unique characteristics, such as small size, good tissue penetration, and cost-effective production, making Nbs a good ...
Wenyuan Shang +6 more
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Development of Nanobodies Against Hemorrhagic and Myotoxic Components of Bothrops atrox Snake Venom
Frontiers in Immunology, 2020 Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites.
Henri Bailon Calderon +19 more
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Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc.
PLoS ONEThe activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and learning, stress regulation, and ...
José M Godoy Muñoz +9 more
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