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Nanobodies that Neutralize HIV [PDF]
Vaccines, 2019 Nanobodies or VHH (variable domains of heavy-chain only antibodies) are derived from camelid species such as llamas and camels. Nanobodies isolated and selected through phage display can neutralize a broad range of human immunodeficiency virus type 1 ...
Robin A. Weiss, C. Theo Verrips
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Seminars in Immunology, 2021 For treatment and diagnosis of cancer, antibodies have proven their value and now serve as a first line of therapy for certain cancers. A unique class of antibody fragments called nanobodies, derived from camelid heavy chain-only antibodies, are gaining increasing acceptance as diagnostic tools and are considered also as building blocks for chimeric ...
Hidde Ploegh, Andrew W Woodham
exaly +4 more sources
Development and Characterization of Nanobodies Targeting the Kupffer Cell
Frontiers in Immunology, 2021 Nanobodies that are derived from single-chain antibodies of camelids have served as powerful tools in diagnostics, therapeutics and investigation of membrane receptors' structure and function. In this study, we developed a series of nanobodies by a phage
Fang Zheng +17 more
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Bispecific nanobodies targeting Bet v 1 and ICAM-1 decrease respiratory epithelial penetration of Bet v 1 [PDF]
Frontiers in ImmunologyBackgroundThe major birch pollen allergen Bet v 1 primarily affects the nose and eyes of allergic patients. After crossing the epithelial barrier, it causes IgE-mediated effector cell release, triggering inflammatory responses.
Ines Zettl +11 more
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Frontiers in Pharmacology, 2022 The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation.
Björn Rissiek +2 more
exaly +3 more sources
NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) [PDF]
Разработка и регистрация лекарственных средств, 2019 Introduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are ...
A. V. Shatalova +3 more
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Nanobodies as molecular imaging probes
Free Radical Biology and Medicine, 2022 Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies (Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their desirable properties such as small size, high specificity, strong affinity, excellent stability, and modularity, nanobodies are on their way to overtake conventional antibodies in
Sarah Barakat +4 more
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Oligoclonal selection of nanobodies targeting vascular endothelial growth factor
Journal of Immunotoxicology, 2019 While monoclonal antibodies are efficient therapeutics for cancer treatment, nanobodies or variable heavy domain – due to their small size, high stability, and solubility – have many advantages in comparison.
Mehrdad Ahadi +3 more
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BMC Genomics, 2017 Background Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae.
Jing Zuo +9 more
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Nanobodies—Useful Tools for Allergy Treatment?
Frontiers in Immunology, 2020 In the last decade single domain antibodies (nanobodies, VHH) qualified through their unique characteristics have emerged as accepted and even advantageous alternative to conventional antibodies and have shown great potential as diagnostic and ...
Sabine Flicker +2 more
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