Results 41 to 50 of about 14,448 (252)
Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics [PDF]
Frontiers in Immunology, 2017 Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal target recognition module of a conventional antibody is composed of two non-covalently associated variable domains (VH and VL).
Peter Bannas +2 more
openaire +3 more sources
Characterisation of anti-Mesothelin nanobodies in order to treat malignant pleural mesothelioma
, 2023 reservedThe malignant pleural mesothelioma, a neoplasm arising from mesothelioma cells, has a very poor prognosis since the standard chemotherapy has a bad response rate.
BUZIOL, LAURA
core
Cloning and characterisation of nanobodies against the coat protein of Zucchini yellow mosaic virus
Plant Protection Science, 2018 Zucchini yellow mosaic virus (ZYMV), in the family Potyviridae, causes an economically important disease. Antibodies are valuable reagents for diagnostic assays to rapidly detect viral infection.
Adel M. Zakri +8 more
doaj +1 more source
Nanobodies in cell-mediated immunotherapy: On the road to fight cancer
Frontiers in Immunology, 2023 The immune system is essential in recognizing and eliminating tumor cells. The unique characteristics of the tumor microenvironment (TME), such as heterogeneity, reduced blood flow, hypoxia, and acidity, can reduce the efficacy of cell-mediated immunity.
Amirhosein Maali +9 more
doaj +1 more source
, 2023 reservedI carcinomi esofagei sono fra i tumori più aggressivi in quanto la sopravvivenza a 5 anni è inferiore al 20%. L’aumento allarmante del numero di casi nei paesi più sviluppati mette in risalto la necessità di sviluppare nuovi approcci ...
FRANZIN, ELISA
core
Frontiers in Bioengineering and Biotechnology, 2022 Nanobodies® (VHH antibodies), are small peptides that represent the antigen binding domain, VHH of unique single domain antibodies (heavy chain only antibodies, HcAb) derived from camelids.
Marco Pitino +4 more
doaj +1 more source
Molecular and Cellular Endocrinology, 2019 The family of G protein-coupled receptors (GPCRs) is the largest class of membrane proteins and an important drug target due to their role in many (patho)physiological processes. Besides small molecules, GPCRs can be targeted by biologicals including antibodies and antibody fragments.
De Groof, Timo +3 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity
Advanced Science, EarlyView.This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley +1 more source
Visual and High-Efficiency Secretion of SARS-CoV-2 Nanobodies with Escherichia coli
BiomoleculesNanobodies have gained attention as potential therapeutic and diagnostic agents for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to their ability to bind and neutralize the virus.
Shuai Zhao +8 more
doaj +1 more source