Results 61 to 70 of about 16,217 (195)

High-throughput CRISPR for Generating Therapeutic Nanobodies

, 2022
Engineered antibodies have had a widespread impact throughout biomedical sciences, from their use as fundamental research tools to their employment as therapeutics.
Rowe, Jacob B, Lee, Kyutae, Isom, Daniel   +2 more
core   +1 more source

Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function

Frontiers in Endocrinology, 2018
Multi-membrane spanning proteins, such as G protein-coupled receptors (GPCRs) and ion channels, are extremely difficult to purify as native proteins. Consequently, the generation of antibodies that recognize the native conformation can be challenging. By
Xavier Peyrassol, Toon Laeremans, Toon Laeremans, Toon Laeremans, Vannessa Lahura, Maja Debulpaep, Maja Debulpaep, Maja Debulpaep, Hassan El Hassan, Hassan El Hassan, Hassan El Hassan, Jan Steyaert, Jan Steyaert, Marc Parmentier, Marc Parmentier, Ingrid Langer   +15 more
doaj   +1 more source

Nanobody Conjugates for Targeted Cancer Therapy and Imaging

Technology in Cancer Research & Treatment, 2021
Conventional antibody-based targeted cancer therapy is one of the most promising avenues of successful cancer treatment, with the potential to reduce toxic side effects to healthy cells surrounding tumor cells.
Wei Kang PhD, Chuanfeng Ding BM, Danni Zheng BS, Xiao Ma BS, Lun Yi BS, Xinyi Tong BS, Chuang Wu MD, Chuang Xue PhD, Yongsheng Yu PhD, Qian Zhou MD   +9 more
doaj   +1 more source

Nanobodies Enhancing Cancer Visualization, Diagnosis and Therapeutics

, 2021
Worldwide, cancer is a serious health concern due to the increasing rates of incidence and mortality. Conventional cancer imaging, diagnosis and treatment practices continue to substantially contribute to the fight against cancer.
Dhaneshree Bestinee Naidoo, Anil Amichund Chuturgoon   +1 more
core   +1 more source

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Journal of Nanobiotechnology, 2023
Background The opening of pannexin1 channels is considered as a key event in inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers inflammasome signaling and activation of immune cells.
Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken   +6 more
doaj   +1 more source

Neutralization potency of TcdA and TcdB nanobodies.

, 2023
Neutralization potency of TcdA and TcdB nanobodies.
John A. Shupe (12102396), Rebecca A. Shrem (17271455), Shannon L. Kordus (4446445), Brian E. Wadzinski (159785), Heather K. Kroh (17271449), Benjamin W. Spiller (411507), F. Christopher Peritore-Galve (12102393), Rubén Cano Rodríguez (17271452), D. Borden Lacy (8297391)   +8 more
core   +1 more source

Anti-IgD nanobodies as novel tools for studying human IgD biology

Scientific Reports
IgD is the least well characterized of mammalian antibody isotypes and its biology remains poorly understood. Nanobodies are a useful and versatile tool for research and diagnostics, including for protein purification, capture and detection applications.
Susan K. Vester, Rebecca L. Beavil, Alexander Alexandrovich, Hannah J. Gould, Andrew J. Beavil, Brian J. Sutton, James M. McDonnell   +6 more
doaj   +1 more source

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector

Pathogens
Prion diseases are fatal neurodegenerative disorders affecting humans and animals, and the central pathogenic event is the conversion of normal prion protein (PrPC) into the pathogenic PrPSc isoform.
Jingjing Zhang, Mengfei Wang, Dan Wang, Xiangyi Zhang, Yue Ma, Els Pardon, Jan Steyaert, Romany Abskharon, Fei Wang, Jiyan Ma   +9 more
doaj   +1 more source

Functionalized nanobodies for cancer therapy [PDF]

, 2014
Cancer treatment is complicated by the high similarity between cancerous and healthy tissue. New anti-cancer drugs, the monoclonal antibodies, act on one specific molecule/process and thereby minimize side effects.
van Vught, R.W.M.
core   +1 more source

Nanobodies: A new frontier in antiviral therapies

SLAS Discovery
Nanobodies, derived from the immune systems of camelids such as alpacas and llamas, represent a novel class of therapeutics with significant potential in fighting respiratory viral infections, such as SARS-CoV-2 and influenza.
Ahmed Mohammed, Mujahed I. Muustafa
doaj   +1 more source