Results 81 to 90 of about 14,448 (252)

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Tiny But Mighty - Nanobodies Tafesse

, 2023
In this video, from Digital World Biology, Dr. Tavasa discusses research on tuberculosis (TB) and the development of nanobodies as potential diagnostic and therapeutic tools. During the video, Dr.
Tafesse, Fikadu G.
core  

Designer Autocrine Signaling Networks for Discovering GPCR-modulating Nanobodies

, 2023
ID 26074 Poster Board 481 Nanobodies are small antibody-derived proteins suited for recognizing structural motifs and surface facets of target proteins with high specificity.
Taylor, Sam, Lee, Kyutae, Isom, Daniel, Rowe, Jacob   +3 more
core   +1 more source

Epitope‐Resolved Digital SERS Profiling of Structurally Dynamic Antigens via a Multi‐Epitope Bispecific Antibody Framework

Advanced Science, EarlyView.
A multi‐epitope digital surface‐enhanced Raman spectroscopy framework enables epitope‐resolved immunoprofiling by integrating bispecific antibody fragments with spectrally encoded nanotags. This approach decouples binding events into independent digital channels, allowing structure‐aware antigen analysis.
Jing Wang, Quan Zhou, Kym Lowry, Christopher B. Howard, Matt Trau   +4 more
wiley   +1 more source

Nanobodies: new avenue to treat kidney disease

, 2021
Current therapeutic options for renal diseases are limited, and the search for disease-specific treatments is ongoing. Nanobodies, single-domain antibodies with many advantages over conventional antibodies, provide flexible, easy-to-format biologicals ...
Liaukouskaya, Nastassia, Eden, Thomas, Wanner, Nicola, Koch-Nolte, Friedrich   +3 more
core   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Camelid immunoglobulins and nanobody technology [PDF]

Veterinary Immunology and Immunopathology, 2009
It is well established that all camelids have unique antibodies circulating in their blood. Unlike antibodies from other species, these special antibodies are devoid of light chains and are composed of a heavy-chain homodimer. These so-called heavy-chain antibodies (HCAbs) are expressed after a V-D-J rearrangement and require dedicated constant gamma ...
Muyldermans, S, Baral, TN, Retarnozzo, VC, De Baetselier, P, De Genst, E, Kinne, J, Leonhardt, H, Magez, Stefan, Nguyen, VK, Revets, H, Rothbauer, U, Stijemans, B, Tillib, S, Wernery, U, Wyns, L, Hassanzadeh-Ghassabeh, G, Saerens, D   +16 more
openaire   +5 more sources

Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization.

, 2017
Norovirus is the leading cause of gastroenteritis worldwide. Despite recent developments in norovirus propagation in cell culture, these viruses are still challenging to grow routinely.
Grant S Hansman, Anna D. Koromyslova, Hansman, GS, Anna D Koromyslova, Grant S. Hansman, Koromyslova, AD   +5 more
core   +1 more source

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Journal of Nanobiotechnology, 2023
Background The opening of pannexin1 channels is considered as a key event in inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers inflammasome signaling and activation of immune cells.
Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken   +6 more
doaj   +1 more source

Endobody: Genetically Encodable Nanobody‐CPP Chimeras for Degradation of Membrane and Extracellular Proteins

Advanced Science, EarlyView.
We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou, Huiping He, Simin Xia, Xi Chen   +3 more
wiley   +1 more source