Results 81 to 90 of about 19,910 (273)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Nanobody Conjugates for Targeted Cancer Therapy and Imaging

Technology in Cancer Research & Treatment, 2021
Conventional antibody-based targeted cancer therapy is one of the most promising avenues of successful cancer treatment, with the potential to reduce toxic side effects to healthy cells surrounding tumor cells.
Wei Kang PhD, Chuanfeng Ding BM, Danni Zheng BS, Xiao Ma BS, Lun Yi BS, Xinyi Tong BS, Chuang Wu MD, Chuang Xue PhD, Yongsheng Yu PhD, Qian Zhou MD   +9 more
doaj   +1 more source

Development of the nanobody display technology to target lentiviral vectors to antigen-presenting cells [PDF]

, 2012
Lentiviral vectors (LVs) provide unique opportunities for the development of immunotherapeutic strategies, as they transduce a variety of cells in situ, including antigen-presenting cells (APCs). Engineering LVs to specifically transduce APCs is required
Breckpot, Karine, De Baetselier, Patrick, De Groeve, Kurt, Dingemans, Jozef, Goyvaerts, Cleo, Heirman, Carlo, Raes, Geert, Reiser, J, Robays, Lander, Thielemans, Kris, Van Lint, Sandra   +10 more
core   +1 more source

The Therapeutic Potential of Nanobodies [PDF]

BioDrugs, 2019
Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with the implementation of nanoparticles for disease prevention, diagnosis, therapy and follow-up.
Ivana Jovčevska, Serge Muyldermans
openaire   +2 more sources

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Journal of Nanobiotechnology, 2023
Background The opening of pannexin1 channels is considered as a key event in inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers inflammasome signaling and activation of immune cells.
Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken   +6 more
doaj   +1 more source

Seed produced anti ETEC antibodies for oral passive immunisation of piglets against post weaning diarrhoea [PDF]

, 2011
C
Coddens, Annelies, Cox, Eric, De Buck, Sylvie, De Greve, Henri, Depicker, Anna, Hofmeisterova, Hana, Virdi, Vikram   +6 more
core   +1 more source

Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function [PDF]

, 2018
Cancer cell-derived extracellular vesicles (EVs) are increasingly being recognized as genuine invasive structures as they contribute to many aspects of invasion and metastasis.
Beghein, Els, Devriese, Delphine, Gettemans, Jan, Van Hoey, Evy   +3 more
core   +2 more sources

NANOBODIES(®): A Review of Generation, Diagnostics and Therapeutics

, 2023
NANOBODY(®) (a registered trademark of Ablynx N.V) molecules (Nbs), also referred to as single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG antibodies found in the Camelidae family. Due to their small size, simple structure, high antigen binding affinity, and remarkable stability in extreme conditions, nanobodies possess ...
Jin, Bo-Kyung, Odongo, Steven, Radwanska, Magdalena, Stefan, Magez   +3 more
openaire   +2 more sources

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source