Results 71 to 80 of about 19,910 (273)

Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function

Frontiers in Endocrinology, 2018
Multi-membrane spanning proteins, such as G protein-coupled receptors (GPCRs) and ion channels, are extremely difficult to purify as native proteins. Consequently, the generation of antibodies that recognize the native conformation can be challenging. By
Xavier Peyrassol, Toon Laeremans, Toon Laeremans, Toon Laeremans, Vannessa Lahura, Maja Debulpaep, Maja Debulpaep, Maja Debulpaep, Hassan El Hassan, Hassan El Hassan, Hassan El Hassan, Jan Steyaert, Jan Steyaert, Marc Parmentier, Marc Parmentier, Ingrid Langer   +15 more
doaj   +1 more source

In planta expression of nanobody-based designer chicken antibodies targeting Campylobacter [PDF]

, 2018
Campylobacteriosis is a widespread infectious disease, leading to a major health and economic burden. Chickens are considered as the most common infection source for humans. Campylobacter mainly multiplies in the mucus layer of their caeca.
De Greve, Henri, Depicker, Anna, Elseviers, Jelle, Garcia Rodriguez, Gabriela, Haesebrouck, Freddy, Hassanzadeh-Ghassabeh, Gholamreza, Hernalsteens, Jean-Pierre, Martel, An, Martens, Edo, Pasmans, Frank, Vanmarsenille, Charlotte, Yvanoff, Charlotte   +11 more
core   +4 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Identification and characterization of nanobodies specifically against African swine fever virus major capsid protein p72

Frontiers in Microbiology, 2022
African swine fever virus (ASFV) is a large and very complex DNA virus. The major capsid protein p72 is the most predominant structural protein and constitutes the outmost icosahedral capsid of the virion.
Jifei Yang, Mengyao Jing, Qingli Niu, Jinming Wang, Yaru Zhao, Yaru Zhao, Meng Liu, Guiquan Guan, Jianxun Luo, Hong Yin, Hong Yin, Zhijie Liu, Zhijie Liu   +12 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Uniform Orientation of Biotinylated Nanobody as an Affinity Binder for Detection of Bacillus thuringiensis (Bt) Cry1Ac Toxin

Toxins, 2014
Nanobodies are the smallest natural fragments with useful properties such as high affinity, distinct paratope and high stability, which make them an ideal tool for detecting target antigens.
Min Li, Min Zhu, Cunzheng Zhang, Xianjin Liu, Yakun Wan   +4 more
doaj   +1 more source

Spontaneous emission rate of an excited atom placed near a nanofiber

, 2002
The spontaneous decay rates of an excited atom placed near a dielectric cylinder are investigated. A special attention is paid to the case when the cylinder radius is small in comparison with radiation wavelength (nanofiber or photonic wire).
't Hooft, Braginsky, Braginsky, Bykov, Chance, Chew, Collot, Fermi, Goy, Jhe, John, Klimov, Klimov, Klimov, Kocharovsky, Lagarkov, Lin, Mie, Pendry, Purcell, Sandoghdar, Shelby, Shelby, Smith, Smith, V.V. Klimov, Veselago, Yablonovich   +27 more
core   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Epidemiological tools for effective surveillance of porcine cysticercosis in Africa [PDF]

, 2014
peer ...
Farougou, S., Goussanou, J.S.E, Korsak Koulagenko, Nicolas, Kpodekon, M.T., Youssao, A.K.I.   +4 more
core   +11 more sources

Antibody RING-Mediated Destruction of Endogenous Proteins [PDF]

, 2020
International ...
Abidi, Naima, Dickerson, David, Hay, Ronald T., Ibrahim, Adel F. M., Prescott, Alan R., Shen, Linnan, Tatham, Michael H., Xirodimas, Dimitris P.   +7 more
core   +4 more sources