Results 71 to 80 of about 16,217 (195)

Characterisation of nanobodies directed against emerging viruses

, 2022
The emergence of new viral pathogens, such as SARS-CoV-2, or re-emergence of known pathogens, like CHIKV, point out the need for further understanding of the biology behind viruses, as well as the urgent need for the development of therapeutic and ...
Ainhoa Moliner Morro (18664294)
core   +1 more source

A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Food Chemistry
To break through the bottleneck in preparation of nanobody (Nb) for chemical contaminants induced by the difficulties in the synthesis of immunogen, complexity and unexpectable efficiency of immunization, a novel strategy to generate Nbs based on the designed synthetic Nb libraries with final size up to 109 cfu/mL was adopted and succeeded in selection
Fang, Ruyu, Li, Yingxue, Liu, Fei, Liang, Yifan, Wang, Yu, Zhong, Guohua, Xu, Zhenlin, Hammock, Bruce D., Wang, Hong   +8 more
openaire   +3 more sources

Nanobodies: a new paradigm for brain disorder therapies

International audienceCamelid-derived nanobodies offer a promising alternative to conventional antibodies for the treatment of brain disorders.
Rondard, Philippe, Prézeau, Laurent, Pin, Jean-Philippe, Lafon, Pierre-André   +3 more
core   +1 more source

Designer Autocrine Signaling Networks for Discovering GPCR-modulating Nanobodies

, 2023
ID 26074 Poster Board 481 Nanobodies are small antibody-derived proteins suited for recognizing structural motifs and surface facets of target proteins with high specificity.
Taylor, Sam, Lee, Kyutae, Isom, Daniel, Rowe, Jacob   +3 more
core   +1 more source

Characterising nanobody developability to improve therapeutic design using the Therapeutic Nanobody Profiler

Communications Biology
Developability optimisation is an important step for successful biotherapeutic design. For monoclonal antibodies, developability is relatively well characterised. However, progress for novel biotherapeutics such as nanobodies is more limited. Differences
Gemma L. Gordon, João Gervasio, Colby Souders, Charlotte M. Deane   +3 more
doaj   +1 more source

Development of SNAP-Tag Based Nanobodies as Secondary Antibody Mimics for Indirect Immunofluorescence Assays

Cells
The immunofluorescence assay is widely used for cellular biology and diagnosis applications. Such an antigen–antibody detection system enables the assessment and visualization of the expression and localization of target proteins.
Wenjie Sheng, Chaoyu Zhang, T. M. Mohiuddin, Marwah Al-Rawe, Roland Schmitz, Marcus Niebert, Lutz Konrad, Steffen Wagner, Felix Zeppernick, Ivo Meinhold-Heerlein, Ahmad Fawzi Hussain   +10 more
doaj   +1 more source

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry [PDF]

, 2018
The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facilitating HIV entry. Accordingly, CXCR4 is considered as an attractive therapeutic target.
Zhao, Chunxia, Smit, Martine J., de Haard, Hans, Smit, Martine J.; id_orcid, Van Hout, Anneleen, van der Woning, Bas, Rucker, Joseph B., Klarenbeek, Alex, Heukers, Raimond, Verrips, Theo, Vermeire, Kurt, Handel, Tracy, Van Loy, Tom, Schols, Dominique, Bobkov, Vladimir, Arimont, Marta, Doijen, Jordi, Rimkunas, Rebecca, de Graaf, Chris   +18 more
core   +1 more source

Serial Llama Immunization with Various SARS-CoV-2 RBD Variants Induces Broad Spectrum Virus-Neutralizing Nanobodies

Vaccines
The emergence of SARS-CoV-2 mutant variants has posed a significant challenge to both the prevention and treatment of COVID-19 with anti-coronaviral neutralizing antibodies. The latest viral variants demonstrate pronounced resistance to the vast majority
Pavel P. Solodkov, Alexander M. Najakshin, Nikolai A. Chikaev, Sergey V. Kulemzin, Ludmila V. Mechetina, Konstantin O. Baranov, Sergey V. Guselnikov, Andrey A. Gorchakov, Tatyana N. Belovezhets, Anton N. Chikaev, Olga Y. Volkova, Alexander G. Markhaev, Yulia V. Kononova, Alexander Y. Alekseev, Marina A. Gulyaeva, Alexander M. Shestopalov, Alexander V. Taranin   +16 more
doaj   +1 more source

Characterization of Nanobodies Targeting RecA: A Strategy for Bacterial SOS Response Inhibition

reservedThe global rise of antimicrobial resistance (AMR) presents a major threat to public health. A key contributor to AMR is the bacterial SOS response, a conserved DNA repair mechanism triggered by genotoxic stress.
BIRRO, GIACOMO
core  

Camelid-Derived Nanobodies Targeting Human Epidermal Growth Factor Receptor: Screening, Expression, and Functional Validation

Antibodies
Objectives: The epidermal growth factor receptor (EGFR) is a clinically relevant membrane receptor that is frequently overexpressed or dysregulated in multiple types of cancer, making it an important target for antibody-based strategies.
Yunfeng Liu, Qiting Huang, Dongna Zhang, Yingjun Wang, Shuaiying Zhao, Jianchuan Wen, Yingying Kong, Jianfeng Xu   +7 more
doaj   +1 more source