Results 51 to 60 of about 14,448 (252)
Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies
Frontiers in Immunology, 2021 The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of tumor banks remains limited.
Sayda Dhaouadi +18 more
doaj +1 more source
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
Applications of Nanobodies in Mycotoxin Detection
, 2022 Mycotoxins, as secondary metabolites produced by fungi, are a common threat to food safety and are hazardous to human and livestock health. Mycotoxin contamination of agricultural products causes significant economic losses worldwide.
Shaowen WU +3 more
core +1 more source
Advanced Science, EarlyView.A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang +13 more
wiley +1 more source
Generation and characterization of Nanomedicines stabilizing alpha-1 antitrypsin
, 2022 reservedSviluppo e caratterizzazione di nanobodies per malattie infiammatorie polmonariGeneration and characterization of nanobodies against lung ...
LESTANI, SARA
core
Neutralization potency of TcdA and TcdB nanobodies.
, 2023 Neutralization potency of TcdA and TcdB nanobodies.
John A. Shupe (12102396) +8 more
core +1 more source
Nanobodies against the myelin enzyme CNPase as tools for structural and functional studies
2′,3′‐Cyclic nucleotide 3′‐phosphodiesterase (CNPase) is an abundant constituent of central nervous system non‐compact myelin, and its loss in mice and humans causes neurodegeneration.
Körner, Henrike +10 more
core +2 more sources
Development of Nanobodies Against Hemorrhagic and Myotoxic Components of Bothrops atrox Snake Venom
Frontiers in Immunology, 2020 Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites.
Henri Bailon Calderon +19 more
doaj +1 more source
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Generation of glycan-specific nanobodies
Cell Chemical Biology, 2022 The development of antibodies that target specific glycan structures on cancer cells or human pathogens poses a significant challenge due to the immense complexity of naturally occurring glycans. Automated glycan assembly enables the production of structurally homogeneous glycans in amounts that are difficult to derive from natural sources. Nanobodies (
Sana Khan Khilji +14 more
openaire +4 more sources