Oligoclonal selection of nanobodies targeting vascular endothelial growth factor
Journal of Immunotoxicology, 2019 While monoclonal antibodies are efficient therapeutics for cancer treatment, nanobodies or variable heavy domain – due to their small size, high stability, and solubility – have many advantages in comparison.
Mehrdad Ahadi +3 more
doaj +1 more source
Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2
iScience, 2022 Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease.
Phillip Pymm +23 more
doaj +1 more source
Spontaneous emission of an atom placed near a nanobelt of elliptical cross-section [PDF]
, 2007 Spontaneous emission of an atom (molecule) placed near a nanocylinder of elliptical cross-section of an arbitrary composition is studied. The analytical expressions have been obtained for the radiative and nonradiative channels of spontaneous decay and ...
B. Z. Katsenelenbaum +21 more
core +2 more sources
Electrochemical detection of Toxocara canis excretory-secretory antigens in children from rural communities in Esmeraldas Province, Ecuador: association between active infection and high eosinophilia. [PDF]
, 2020 BACKGROUND: The diagnosis of active Toxocara canis infections in humans is challenging. Larval stages of T. canis do not replicate in human tissues and disease may result from infection with a single T. canis larva.
Chico, M +9 more
core +3 more sources
Nanobody-Displaying Flagellar Nanotubes [PDF]
Scientific Reports, 2018 AbstractIn this work we addressed the problem how to fabricate self-assembling tubular nanostructures displaying target recognition functionalities. Bacterial flagellar filaments, composed of thousands of flagellin subunits, were used as scaffolds to display single-domain antibodies (nanobodies) on their surface.
Ágnes Klein +6 more
openaire +3 more sources
Nanobodies as molecular imaging probes
Free Radical Biology and Medicine, 2022 Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies (Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their desirable properties such as small size, high specificity, strong affinity, excellent stability, and modularity, nanobodies are on their way to overtake conventional antibodies in
Sarah Barakat +4 more
openaire +4 more sources
Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor. [PDF]
, 2017 About 50% of the world's arable land is strongly acidic (pH ≤ 5). The low pH solubilizes root-toxic ionic aluminium (Al3+) species from clay minerals, driving the evolution of counteractive adaptations in cultivated crops.
Chang, Geoffrey +6 more
core +3 more sources
Revolutionizing antiviral therapy with nanobodies: Generation and prospects
Biotechnology Reports, 2023 As the world continues to grapple with infectious diseases, scientists are constantly searching for effective ways to combat these deadly pathogens. One promising avenue of research is the use of nanobodies as neutralization agents. These small proteins,
Mujahed I. Mustafa, Ahmed Mohammed
doaj +1 more source
Exploring cellular biochemistry with nanobodies [PDF]
Journal of Biological Chemistry, 2020 Reagents that bind tightly and specifically to biomolecules of interest remain essential in the exploration of biology and in their ultimate application to medicine. Besides ligands for receptors of known specificity, agents commonly used for this purpose are monoclonal antibodies derived from mice, rabbits, and other animals.
Cheloha, Ross W +4 more
openaire +2 more sources
BMC Genomics, 2017 Background Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae.
Jing Zuo +9 more
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