Results 31 to 40 of about 11,503 (243)
MicrobiologyOpen, 2022 Necrotic enteritis (NE), caused by Clostridium perfringens, is an intestinal disease with devastating economic losses to the poultry industry. NE is a complex disease and predisposing factors that compromise gut integrity are required to facilitate C ...
Dharanesh Gangaiah +8 more
doaj +1 more source
Applications of nanobodies in brain diseases
Frontiers in Immunology, 2022 Nanobodies are antibody fragments derived from camelids, naturally endowed with properties like low molecular weight, high affinity and low immunogenicity, which contribute to their effective use as research tools, but also as diagnostic and therapeutic ...
Fang Zheng +7 more
doaj +1 more source
Cloning and characterisation of nanobodies against the coat protein of Zucchini yellow mosaic virus
Plant Protection Science, 2018 Zucchini yellow mosaic virus (ZYMV), in the family Potyviridae, causes an economically important disease. Antibodies are valuable reagents for diagnostic assays to rapidly detect viral infection.
Adel M. Zakri +8 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Nanobodies® (VHH antibodies), are small peptides that represent the antigen binding domain, VHH of unique single domain antibodies (heavy chain only antibodies, HcAb) derived from camelids.
Marco Pitino +4 more
doaj +1 more source
Nanobodies in cell-mediated immunotherapy: On the road to fight cancer
Frontiers in Immunology, 2023 The immune system is essential in recognizing and eliminating tumor cells. The unique characteristics of the tumor microenvironment (TME), such as heterogeneity, reduced blood flow, hypoxia, and acidity, can reduce the efficacy of cell-mediated immunity.
Amirhosein Maali +9 more
doaj +1 more source
Molecular and Cellular Endocrinology, 2019 The family of G protein-coupled receptors (GPCRs) is the largest class of membrane proteins and an important drug target due to their role in many (patho)physiological processes. Besides small molecules, GPCRs can be targeted by biologicals including antibodies and antibody fragments.
De Groof, Timo +3 more
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Visual and High-Efficiency Secretion of SARS-CoV-2 Nanobodies with Escherichia coli
BiomoleculesNanobodies have gained attention as potential therapeutic and diagnostic agents for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to their ability to bind and neutralize the virus.
Shuai Zhao +8 more
doaj +1 more source
Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies
Frontiers in Immunology, 2021 The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of tumor banks remains limited.
Sayda Dhaouadi +18 more
doaj +1 more source