Results 21 to 30 of about 11,503 (243)
Recent advances of nanobody applications in diagnosis and detection
MedComm – Biomaterials and Applications, 2023 Nanobodies (Nbs) are the variable domain of heavy‐chain antibodies derived from the blood of camelids or sharks. Nanobodies are the smallest antibody fragment with intact antigen‐binding ability.
Qianling Su +5 more
doaj +1 more source
NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW)
Разработка и регистрация лекарственных средств, 2019 Introduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are ...
A. V. Shatalova +3 more
doaj +1 more source
A general approach for stabilizing nanobodies for intracellular expression
eLife, 2022 Conventional antibodies and their derived fragments are difficult to deploy against intracellular targets in live cells, due to their bulk and structural complexity.
John G Dingus +4 more
doaj +1 more source
Oligoclonal selection of nanobodies targeting vascular endothelial growth factor
Journal of Immunotoxicology, 2019 While monoclonal antibodies are efficient therapeutics for cancer treatment, nanobodies or variable heavy domain – due to their small size, high stability, and solubility – have many advantages in comparison.
Mehrdad Ahadi +3 more
doaj +1 more source
Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2
iScience, 2022 Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease.
Phillip Pymm +23 more
doaj +1 more source
The Therapeutic Potential of Nanobodies [PDF]
BioDrugs, 2019 Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with the implementation of nanoparticles for disease prevention, diagnosis, therapy and follow-up.
Ivana Jovčevska, Serge Muyldermans
openaire +2 more sources
Revolutionizing antiviral therapy with nanobodies: Generation and prospects
Biotechnology Reports, 2023 As the world continues to grapple with infectious diseases, scientists are constantly searching for effective ways to combat these deadly pathogens. One promising avenue of research is the use of nanobodies as neutralization agents. These small proteins,
Mujahed I. Mustafa, Ahmed Mohammed
doaj +1 more source
Nanobodies as modulators of inflammation: potential applications for acute brain injury
Frontiers in Cellular Neuroscience, 2014 Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are ...
Björn eRissiek +2 more
doaj +1 more source
Nanobodies as molecular imaging probes
Free Radical Biology and Medicine, 2022 Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies (Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their desirable properties such as small size, high specificity, strong affinity, excellent stability, and modularity, nanobodies are on their way to overtake conventional antibodies in
Sarah Barakat +4 more
openaire +4 more sources
BMC Genomics, 2017 Background Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae.
Jing Zuo +9 more
doaj +1 more source