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Nanobodies in therapeutic applications.
Current opinion in molecular therapeutics, 2007 Over the years, many antibodies have been successfully generated to treat patients with life-threatening diseases, most notably cancer. While the first generation of antibodies, originating from mice, caused severe side effects and were relatively inefficient, technological advances have made it possible to obtain fully human antibodies for therapeutic
Roovers, R.C. +2 more
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Frontiers in Bioengineering and Biotechnology, 2023 Introduction:Drosophila melanogaster is a model organism for studying developmental biology and human neural disorders. Nanobodies are the variable domains of the heavy chains of camelid heavy-chain antibodies (VHHs) with high affinity to their antigens ...
Jianxiang Qiu +7 more
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Development and Characterization of Nanobodies Targeting the Kupffer Cell
Frontiers in Immunology, 2021 Nanobodies that are derived from single-chain antibodies of camelids have served as powerful tools in diagnostics, therapeutics and investigation of membrane receptors' structure and function. In this study, we developed a series of nanobodies by a phage
Fang Zheng +17 more
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Immunogenicity Risk Profile of Nanobodies [PDF]
Frontiers in Immunology, 2021 Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess unique characteristics, including a minimal size, providing fast pharmacokinetics, high-target specificity, and an affinity in the (sub-)nanomolar range in conjunction with an
Chloé Ackaert +17 more
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iScience, 2021 Summary: Advanced fluorescence microscopy studies require specific and monovalent molecular labeling with bright and photostable fluorophores. This necessity led to the widespread use of fluorescently labeled nanobodies against commonly employed ...
Falk Schneider +3 more
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Frontiers in Immunology, 2023 Single-domain antibodies, also known as nanobodies, are broadly important for studying the structure and conformational states of several classes of proteins, including membrane proteins, enzymes, and amyloidogenic proteins.
Jennifer M. Zupancic +22 more
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Antibodies, 2020 Since their first description in 1993 [...]
Patrick Chames, Ulrich Rothbauer
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Chemogenetic Control of Nanobodies [PDF]
Nature Methods, 2019 ABSTRACT We introduce an engineered nanobody whose affinity to green fluorescent protein (GFP) can be switched on and off with small molecules. By controlling the cellular localization of GFP fusion proteins, the engineered nanobody allows to study their role in basic biological processes, an approach that should be applicable to ...
Farrants, Helen +9 more
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Microorganisms, 2021 Nanobodies are camelid-derived single-domain antibodies that present some advantages versus conventional antibodies, such as a smaller size, and higher tissue penetrability, stability, and hydrophilicity. Although nanobodies can be delivered as proteins,
Noelia Silva-Pilipich +2 more
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Nanobody: a promising toolkit for molecular imaging and disease therapy
EJNMMI Research, 2021 Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration.
Guangfa Bao +3 more
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