Results 1 to 10 of about 23,223 (305)

Nanobody based dual specific CARs [PDF]

International Journal of Molecular Sciences, 2018
Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas.
Abken, Hinrich, Bonte, Sarah, De Munter, Stijn, Goetgeluk, Glenn, Ingels, Joline, Kerre, Tessa, Pille, Melissa, Vandekerckhove, Bart, Weening, Karin   +8 more
core   +6 more sources

Design of a humanized anti vascular endothelial growth factor nanobody and evaluation of its in vitro function [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities.
Fatemeh Kazemi-Lomedasht, serge muyldermans, Mahdi Habibi-Anbouhi, Mahdi Behdani   +3 more
doaj   +1 more source

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles [PDF]

, 2016
Survivin, the smallest member of the inhibitor of apoptosis protein family, plays a central role during mitosis and exerts a cytoprotective function. Survivin is highly expressed in most cancer types and contributes to multiple facets of carcinogenesis ...
Beghein, Els, De Ganck, Ariane, Gettemans, Jan, Van Audenhove, Isabel, Verhelle, Adriaan, Zwaenepoel, Olivier   +5 more
core   +2 more sources

Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4

BMC Cancer, 2022
Background: Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer.
Shuai Hao, Shuyi Xu, Liangzhu Li, Yaxian Li, Meiqi Zhao, Junsheng Chen, Shunying Zhu, Yueqing Xie, Hua Jiang, Jianwei Zhu, Mingyuan Wu   +10 more
doaj   +1 more source

A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo

Frontiers in Oncology, 2021
Breast cancer is the most common malignant cancer in women worldwide, especially in developing countries. Herceptin is a monoclonal antibody with an antitumor effect in HER2-positive breast cancer. However, the large molecular weight of Herceptin limited
Yan Yan, Yan Yan, Xiao Cheng, Lin Li, Rumeng Zhang, Yong Zhu, Zhengsheng Wu, Zhengsheng Wu, Keshuo Ding, Keshuo Ding   +9 more
doaj   +1 more source

Optimizing expression of Nanobody® molecules in Pichia pastoris through co-expression of auxiliary proteins under methanol and methanol-free conditions

Microbial Cell Factories, 2023
Background Ablynx NV, a subsidiary of Sanofi, has a long-standing focus on the development of Nanobody® molecules as biopharmaceuticals (Nanobody® is a registered trademark of Ablynx NV). Nanobody molecules are single variable domains, and they have been
Manu De Groeve, Bram Laukens, Peter Schotte   +2 more
doaj   +1 more source

Rapid Delivery of Nanobodies/VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA

Molecular Therapy: Methods & Clinical Development, 2020
Intracellular antigen labeling and manipulation by antibodies have been long-thought goals in the field of cell research and therapy. However, a central limitation for this application is that antibodies are not able to penetrate into the cytosol of ...
Xuechen Zhou, Rui Hao, Chen Chen, Zhipeng Su, Linhong Zhao, Zhuojuan Luo, Wei Xie   +6 more
doaj   +1 more source

Spontaneous emission of an atom placed near a nanobelt of elliptical cross-section [PDF]

, 2007
Spontaneous emission of an atom (molecule) placed near a nanocylinder of elliptical cross-section of an arbitrary composition is studied. The analytical expressions have been obtained for the radiative and nonradiative channels of spontaneous decay and ...
B. Z. Katsenelenbaum, B. Z. Katsenelenbaum, D. V. Guzatov, D. Y. Chu, E. M. Purcell, J. A. Stratton, J. C. Johnson, K. Oshiro, L.-W. Li, M. A. Rippin, N. N. Kalitkin, P. L. E. Uslenghi, P. M. Morse, P. N. Prasad, R. R. Chance, R. Saito, S. A. Maksimenko, S. D. Brorson, V. V. Klimov, V. V. Klimov, V. V. Klimov, X. Y. Kong   +21 more
core   +2 more sources

Electrochemical detection of Toxocara canis excretory-secretory antigens in children from rural communities in Esmeraldas Province, Ecuador: association between active infection and high eosinophilia. [PDF]

, 2020
BACKGROUND: The diagnosis of active Toxocara canis infections in humans is challenging. Larval stages of T. canis do not replicate in human tissues and disease may result from infection with a single T. canis larva.
Chico, M, Cooper, P, De Wael, K, Morales-Yánez, F, Muyldermans, S, Paredis, L, Polman, K, Roucher, C, Sariego, I, Trashin, S   +9 more
core   +3 more sources

Development of the nanobody display technology to target lentiviral vectors to antigen-presenting cells [PDF]

, 2012
Lentiviral vectors (LVs) provide unique opportunities for the development of immunotherapeutic strategies, as they transduce a variety of cells in situ, including antigen-presenting cells (APCs). Engineering LVs to specifically transduce APCs is required
Breckpot, Karine, De Baetselier, Patrick, De Groeve, Kurt, Dingemans, Jozef, Goyvaerts, Cleo, Heirman, Carlo, Raes, Geert, Reiser, J, Robays, Lander, Thielemans, Kris, Van Lint, Sandra   +10 more
core   +1 more source